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Cytogenetic and molecular analysis of chromosome instability in cattle with reproductive problems / Cytogenetyczna i molekularna analiza niestabilności chromosomów u bydła z problemam w rozrodzie

Cytogenetic and molecular analysis of chromosome instability in cattle with reproductive problems... Summary The cytogenetic and molecular analysis of cattle chromosome instability revealed excessive fragility of chromosome X in q11, q24, q31 and p13 regions in cows with reproductive problems. The highest frequency of structural defects was found in BTAXp13 region containing FRM1 gene locus with unstable trinucleotide CGG repeats which were mapped by in situ PCR method. The results obtained suggest that chromosome X structural instability may be a cause of defective expression of genes related with fertility and it leads to a decrease of reproductive efficiency. The present outcomes can be used in further studies on the cytogenetic and molecular substructure of chromosome instability phenomenon and their phenotypic effects in cattle. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Annales UMCS, Zootechnica de Gruyter

Cytogenetic and molecular analysis of chromosome instability in cattle with reproductive problems / Cytogenetyczna i molekularna analiza niestabilności chromosomów u bydła z problemam w rozrodzie

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References (25)

Publisher
de Gruyter
Copyright
Copyright © 2013 by the
ISSN
0239-4243
eISSN
2083-7399
DOI
10.2478/v10083-012-0027-8
Publisher site
See Article on Publisher Site

Abstract

Summary The cytogenetic and molecular analysis of cattle chromosome instability revealed excessive fragility of chromosome X in q11, q24, q31 and p13 regions in cows with reproductive problems. The highest frequency of structural defects was found in BTAXp13 region containing FRM1 gene locus with unstable trinucleotide CGG repeats which were mapped by in situ PCR method. The results obtained suggest that chromosome X structural instability may be a cause of defective expression of genes related with fertility and it leads to a decrease of reproductive efficiency. The present outcomes can be used in further studies on the cytogenetic and molecular substructure of chromosome instability phenomenon and their phenotypic effects in cattle.

Journal

Annales UMCS, Zootechnicade Gruyter

Published: Oct 1, 2013

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