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Effect of Melatonin Administration on Prevention of Contrast- Induced Nephropathy following Coronary Angiography

Effect of Melatonin Administration on Prevention of Contrast- Induced Nephropathy following... AbstractIntroduction. Contrast-induced-nephropathy (CIN) is a common complication during angiography that may lead to long-term complications. This study was conducted to investigate the effect of melatonin administration on prevention of CIN in patients who underwent coronary angiography with intra-arterial contrast agents. Method. This is single-blind randomized clinical trial that was performed over 100 patients with indication for coronary angiography. Patients are randomly assigned to two equal groups. All patients in the 12 hours before and 12 hours after the procedure, were received adequate intravenous hydration with normal saline and for the intervention group in addition to hydration, the day before angiography and immediately after angiography 3 mg melatonin was administered. For all patients, serum level of creatinine (Cr), blood urea nitrogen (BUN) and glomerular filtration rate (GFR) before and 48 hours after the procedure were measured. Data were analyzed using SPSS 18 software. Results. Totally 100 participants with the mean age of 64.0±8.2 years were enrolled (63% male). There was no significant difference between intervention and control groups in baseline and demographic characteristics (P> 0.05). Although the mean serum Cr and BUN level increased in both groups, but the mean Cr, BUN and GFR before and after coronary angiography was not statistically significant. Based on the definition of CIN in the current study, 3(6%) patients from intervention group and 2(4%) patients from control group were affected by CIN (P = 0.243). Conclusion. It is likely that, melatonin administration has no significant effect on prevention of CIN following coronary angiography. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png BANTAO Journal de Gruyter

Effect of Melatonin Administration on Prevention of Contrast- Induced Nephropathy following Coronary Angiography

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Publisher
de Gruyter
Copyright
© 2017
eISSN
2451-3105
DOI
10.1515/bj-2017-0005
Publisher site
See Article on Publisher Site

Abstract

AbstractIntroduction. Contrast-induced-nephropathy (CIN) is a common complication during angiography that may lead to long-term complications. This study was conducted to investigate the effect of melatonin administration on prevention of CIN in patients who underwent coronary angiography with intra-arterial contrast agents. Method. This is single-blind randomized clinical trial that was performed over 100 patients with indication for coronary angiography. Patients are randomly assigned to two equal groups. All patients in the 12 hours before and 12 hours after the procedure, were received adequate intravenous hydration with normal saline and for the intervention group in addition to hydration, the day before angiography and immediately after angiography 3 mg melatonin was administered. For all patients, serum level of creatinine (Cr), blood urea nitrogen (BUN) and glomerular filtration rate (GFR) before and 48 hours after the procedure were measured. Data were analyzed using SPSS 18 software. Results. Totally 100 participants with the mean age of 64.0±8.2 years were enrolled (63% male). There was no significant difference between intervention and control groups in baseline and demographic characteristics (P> 0.05). Although the mean serum Cr and BUN level increased in both groups, but the mean Cr, BUN and GFR before and after coronary angiography was not statistically significant. Based on the definition of CIN in the current study, 3(6%) patients from intervention group and 2(4%) patients from control group were affected by CIN (P = 0.243). Conclusion. It is likely that, melatonin administration has no significant effect on prevention of CIN following coronary angiography.

Journal

BANTAO Journal – de Gruyter

Published: Jun 27, 2017

References

  • prospective randomized trial of prevention measures in patients at high risk for contrast nephropathy : results of the PRINCE Study Prevention of Radiocontrast Induced Nephropathy Clinical Evaluation of the of
    Stevens
  • Contrast nephropathy of the of
    Murphy
  • Protective effect of melatonin dihydroxyvitamin on renal ischemiareperfusion injury in rats failure
    Sezgin
  • Prospective randomized study of acetylcysteine fenoldopam and saline for prevention of radiocontrast - induced nephropathy and cardiovascular interventions journal of the Society for Cardiac Angiography Interventions
    Allaqaband
  • der Molen Contrast induced nephropathy updated ESUR contrast media safety committee guidelines
    Stacul
  • Preventing nephropathy induced by contrast medium
    Barrett
  • Past and present attempts to prevent radiocontrast nephropathy in cardiovascular
    Bailey
  • induced acute renal failure
    Weisbord
  • The value of serum creatine kinase in predicting the risk of rhabdomyolysis - induced acute kidney injury : a systematic review and meta - analysis Clinical and experimental nephrology
    Safari
  • PA Contrast - induced acute kidney injury of the of
    McCullough
  • The Role of Scoring Systems and Urine Dipstick in Prediction of Rhabdomyolysis - induced Acute a Systematic Iranian journal of kidney diseases
    Safari
  • Theophylline for prevention of contrast - induced nephropathy : a systematic meta - analysis
    Bagshaw
  • Acetylcysteine for the prevention of radiocontrastinduced nephropathy
    Tepel
  • MS Pregnancy Screening before Diagnostic Radiography in Emergency Department an Emergency
    Abushouk
  • Melatonin suppresses cisplatin - induced nephrotoxicity via activation of pathway metabolism
    Kilic
  • Systematic of Iranian Experiences in of trauma research
    Hashemi
  • a pineal secretory product with antioxidant properties protects against cisplatin - induced nephrotoxicity in rats of
    Hara
  • Contrast - induced nephropathy preventive and protective effects of melatonin of
    Gazi
  • the pineal gland and their implications for headache disorders an of
    Peres
  • acetylcysteine multiple clinical applications family
    Millea
  • WM Performance of the Cockcroft New CKDEPI Formulas in Relation to Body Size the of
    Michels
  • Ameliorative effect of melatonin against contrast media induced renal tubular cell injury of medical
    Nasri
  • Oral acetylcysteine as an adjunct to saline hydration for the prevention of contrast - induced nephropathy following coronary angiography randomized controlled trial and review of the current literature
    Goldenberg
  • Contrast - induced nephropathy definition patients at risk Supplement
    Mehran
  • Analgesic effects of melatonin : a review of current evidence from experimental and clinical studies of
    Wilhelmsen
  • Contrast media and the kidney of guidelines The of radiology
    Thomsen