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Hormone Imbalance in Polycystic Ovarian Syndrome

Hormone Imbalance in Polycystic Ovarian Syndrome AbstractPolycystic Ovarian Syndrome (PCOS) is a disease that is characterized by an increased Gonadotropin-Releasing-Hormone (GnRH) pulsatile frequency, causing an altered LH/FSH ratio. More precisely an increased Luteinizing Hormone (LH) secretion compared to a decreased Follicle-Stimulating Hormone (FSH) secretion leads to the development of hyperandrogenism and to a low-level concentration of estrogens and therefore decreased negative estrogenic feedback in the control axis. The purpose of this review is to connect the physiological Hypothalamic-Pituitary-Ovarian (HPO) axis with said pathology and the ensuring discussion about the possible mechanisms of pathogenesis and guidelines for relieving associated symptoms. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Acta Biologica Marisiensis de Gruyter

Hormone Imbalance in Polycystic Ovarian Syndrome

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Publisher
de Gruyter
Copyright
© 2023 Ivan Bergo et al., published by Sciendo
eISSN
2668-5124
DOI
10.2478/abmj-2023-0002
Publisher site
See Article on Publisher Site

Abstract

AbstractPolycystic Ovarian Syndrome (PCOS) is a disease that is characterized by an increased Gonadotropin-Releasing-Hormone (GnRH) pulsatile frequency, causing an altered LH/FSH ratio. More precisely an increased Luteinizing Hormone (LH) secretion compared to a decreased Follicle-Stimulating Hormone (FSH) secretion leads to the development of hyperandrogenism and to a low-level concentration of estrogens and therefore decreased negative estrogenic feedback in the control axis. The purpose of this review is to connect the physiological Hypothalamic-Pituitary-Ovarian (HPO) axis with said pathology and the ensuring discussion about the possible mechanisms of pathogenesis and guidelines for relieving associated symptoms.

Journal

Acta Biologica Marisiensisde Gruyter

Published: Jun 1, 2023

Keywords: Polycystic Ovarian Syndrome; hyperandrogenism; hyperestrogenism; infertility; hirsutism

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