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Prevalence of Hepatitis B in Random Bulgarian Blood Samples – A Single-Site Experience

Prevalence of Hepatitis B in Random Bulgarian Blood Samples – A Single-Site Experience AbstractThe worldwide distribution of the HBV infection has usually been estimated by the prevalence of hepatitis B surface antigen (HBsAg) among the general population. Total antibodies for hepatitis B core antigen (anti-HBc) are the most important diagnostic marker for proving prior exposure to HBV.AimThe aim of this study was to determine the prevalence of Hepatitis B virus (HBV) infection among Bulgarian population. Reliable epidemiologic data is needed to estimate the prevalence of Hepatitis B in order to determine the actual burden of the infection and to plan prevention and control measures.Materials and methodsA total of 2140 serum samples were tested for major serological markers of HBV (HBsAg and anti-HBc) for a period of two years (2018-2019).ResultsWe established an intermediate prevalence of HBsAg (5.1%) and high prevalence of anti-HBc (27%) among HBsAg negative individuals.ConclusionIn conclusion, the prevalence of Hepatitis B is much higher among those born before the introduction of universal hepatitis B vaccination in Bulgaria (1992). http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Acta Medica Bulgarica de Gruyter

Prevalence of Hepatitis B in Random Bulgarian Blood Samples – A Single-Site Experience

Acta Medica Bulgarica , Volume 50 (2): 5 – Jun 1, 2023

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Publisher
de Gruyter
Copyright
© 2023 A. Gotseva et al., published by Sciendo
eISSN
0324-1750
DOI
10.2478/amb-2023-0013
Publisher site
See Article on Publisher Site

Abstract

AbstractThe worldwide distribution of the HBV infection has usually been estimated by the prevalence of hepatitis B surface antigen (HBsAg) among the general population. Total antibodies for hepatitis B core antigen (anti-HBc) are the most important diagnostic marker for proving prior exposure to HBV.AimThe aim of this study was to determine the prevalence of Hepatitis B virus (HBV) infection among Bulgarian population. Reliable epidemiologic data is needed to estimate the prevalence of Hepatitis B in order to determine the actual burden of the infection and to plan prevention and control measures.Materials and methodsA total of 2140 serum samples were tested for major serological markers of HBV (HBsAg and anti-HBc) for a period of two years (2018-2019).ResultsWe established an intermediate prevalence of HBsAg (5.1%) and high prevalence of anti-HBc (27%) among HBsAg negative individuals.ConclusionIn conclusion, the prevalence of Hepatitis B is much higher among those born before the introduction of universal hepatitis B vaccination in Bulgaria (1992).

Journal

Acta Medica Bulgaricade Gruyter

Published: Jun 1, 2023

Keywords: Hepatitis B; HBsAg; anti-HBc; prevalence; Bulgaria

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