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157 Keynote: Understanding Exposure, Hazard Identification, and Human Health Effects: How Ultrafine/Nano Particle Toxicology Influenced Occupational Safety and Health

157 Keynote: Understanding Exposure, Hazard Identification, and Human Health Effects: How... Annals of Work Exposures and Health, 2023, Vol. 67, No. S1, i36–i98 https://doi.org/10.1093/annweh/wxac087 Abstracts Keynotes Abstract citation ID: wxac087.095 157 Keynote: Understanding Exposure, Hazard Identification, and Human Health Effects: How Ultrafine/Nano Particle Toxicology Influenced Occupational Safety and Health Aaron Erdely Health Effects Laboratory Division, NIOSH, Cincinnati, USA Particles and fibers, whether process-derived, engineered, or envir - onmental, have the possibility to cause adverse health effects when inhaled. Historic occupational particulates, such as coal, silica, and asbestos were clearly associated with human disease and induced a human health burden. This necessitated worldwide formation of national institutes to evaluate and mitigate exposures and mechan- isms. The scientific evaluation of historic exposures set the stage for conducting air pollution/particulate matter research demonstrating that adverse health outcomes from particulates created potential risk for the general population, not just an occupational workforce. Research soon showed that adverse effects were not confined to the primary target site (e.g., lung) but also included cardiovascular, neurological, and developmental dysfunction. The evaluation of particulate matter, especially the fine and ultrafine fraction, quickly adapted to the rapid expansion of engineered nanomaterials. However, the study of novel engineered nanomaterials required a transition to preventative measures when interpreting controlled toxicity evaluations. Shifting the paradigm of particulate toxi- cology from explaining a chronic disease to intervening prior to a health burden brought many challenges to toxicologic research, exposure science, and responsible commercialization. Challenges included physicochemical characterization of nanoscale material, toxicologic research proceeding without exposure science guid- ance, and epidemiological investigations without post-exposure timepoints sufficient for evaluating potential induction of chronic disease. The navigation of these challenges shaped current ap- proaches for evaluating multiple emerging technologies as well as influenced perspective on historic particles, especially those which resurface as part of complex mixtures. © The Author(s) 2023. Published by Oxford University Press on behalf of the British Occupational Hygiene Society. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Annals of Work Exposures and Health Oxford University Press

157 Keynote: Understanding Exposure, Hazard Identification, and Human Health Effects: How Ultrafine/Nano Particle Toxicology Influenced Occupational Safety and Health

Annals of Work Exposures and Health , Volume 67 (Supplement_1): 1 – May 10, 2023

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Publisher
Oxford University Press
Copyright
© The Author(s) 2023. Published by Oxford University Press on behalf of the British Occupational Hygiene Society.
ISSN
2398-7308
eISSN
2398-7316
DOI
10.1093/annweh/wxac087.095
Publisher site
See Article on Publisher Site

Abstract

Annals of Work Exposures and Health, 2023, Vol. 67, No. S1, i36–i98 https://doi.org/10.1093/annweh/wxac087 Abstracts Keynotes Abstract citation ID: wxac087.095 157 Keynote: Understanding Exposure, Hazard Identification, and Human Health Effects: How Ultrafine/Nano Particle Toxicology Influenced Occupational Safety and Health Aaron Erdely Health Effects Laboratory Division, NIOSH, Cincinnati, USA Particles and fibers, whether process-derived, engineered, or envir - onmental, have the possibility to cause adverse health effects when inhaled. Historic occupational particulates, such as coal, silica, and asbestos were clearly associated with human disease and induced a human health burden. This necessitated worldwide formation of national institutes to evaluate and mitigate exposures and mechan- isms. The scientific evaluation of historic exposures set the stage for conducting air pollution/particulate matter research demonstrating that adverse health outcomes from particulates created potential risk for the general population, not just an occupational workforce. Research soon showed that adverse effects were not confined to the primary target site (e.g., lung) but also included cardiovascular, neurological, and developmental dysfunction. The evaluation of particulate matter, especially the fine and ultrafine fraction, quickly adapted to the rapid expansion of engineered nanomaterials. However, the study of novel engineered nanomaterials required a transition to preventative measures when interpreting controlled toxicity evaluations. Shifting the paradigm of particulate toxi- cology from explaining a chronic disease to intervening prior to a health burden brought many challenges to toxicologic research, exposure science, and responsible commercialization. Challenges included physicochemical characterization of nanoscale material, toxicologic research proceeding without exposure science guid- ance, and epidemiological investigations without post-exposure timepoints sufficient for evaluating potential induction of chronic disease. The navigation of these challenges shaped current ap- proaches for evaluating multiple emerging technologies as well as influenced perspective on historic particles, especially those which resurface as part of complex mixtures. © The Author(s) 2023. Published by Oxford University Press on behalf of the British Occupational Hygiene Society.

Journal

Annals of Work Exposures and HealthOxford University Press

Published: May 10, 2023

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