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American Journal of Epidemiology Vol. 192, No. 6 © The Author(s) 2023. Published by Oxford University Press on behalf of the Johns Hopkins Bloomberg School of https://doi.org/10.1093/aje/kwad034 Public Health. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com. Advance Access publication: February 9, 2023 The AJE Classroom Interaction in Theory and in Practice: Evaluating Combinations of Exposures in Epidemiologic Research Brian W. Whitcomb and Ashley I. Naimi Correspondence to Dr. Brian Whitcomb, Department of Biostatistics and Epidemiology, University of Massachusetts Amherst, 715 N. Pleasant Street, Amherst, MA 01002 (e-mail: bwhitcom@umass.edu). Initially submitted October 10, 2022; accepted for publication February 7, 2023. THE CONCEPT OF EPIDEMIOLOGIC INTERACTION to frame the question in terms of regression and include a cross-product term in a model of outcome probability (p): The concept of interaction in etiological epidemiologic research can be described as the circumstance where the g(p) = α + α A + α B + α AB, 0 A B AB causal effect of exposure on outcome depends upon another factor. In this sense, epidemiologic research commonly con- in which the effects of dichotomous factors A and B individ- siders interaction,. For example: How is risk of lung cancer ually are represented by
American Journal of Epidemiology – Oxford University Press
Published: Feb 9, 2023
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