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Interferons and inflammation.

Interferons and inflammation. The local inflammatory response to exogenous or endogenous agents is regulated by various humoral factors. Amongst these, the cytokines represent a prominent group to which belong not only cytotoxins, chemotactic factors, and cellular growth factors, but also the interferons. Evidence is reviewed indicating that, at the local level, interferon-gamma (IFN-gamma) constitutes a positive factor triggering or promoting the inflammatory response. Studies employing monoclonal antibodies against IFN-gamma indicate that inflammatory agents, such as bacterial endotoxin, induce local production of IFN-gamma, which acts as an up-regulator of the primary phase of the inflammatory response. Antibodies against IFN-alpha/beta, on the contrary, have so far not been found to affect inflammation. Systemic interferons, on the other hand, seem to fulfil a down-regulating role, as evidenced by the observation that exogenously administered IFN-alpha, -beta, and -gamma inhibit local inflammation. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Journal of interferon research Pubmed

Interferons and inflammation.

Journal of interferon research , Volume 7 (5): 9 – Jan 21, 1988

Interferons and inflammation.


Abstract

The local inflammatory response to exogenous or endogenous agents is regulated by various humoral factors. Amongst these, the cytokines represent a prominent group to which belong not only cytotoxins, chemotactic factors, and cellular growth factors, but also the interferons. Evidence is reviewed indicating that, at the local level, interferon-gamma (IFN-gamma) constitutes a positive factor triggering or promoting the inflammatory response. Studies employing monoclonal antibodies against IFN-gamma indicate that inflammatory agents, such as bacterial endotoxin, induce local production of IFN-gamma, which acts as an up-regulator of the primary phase of the inflammatory response. Antibodies against IFN-alpha/beta, on the contrary, have so far not been found to affect inflammation. Systemic interferons, on the other hand, seem to fulfil a down-regulating role, as evidenced by the observation that exogenously administered IFN-alpha, -beta, and -gamma inhibit local inflammation.

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ISSN
0197-8357
DOI
10.1089/jir.1987.7.559
pmid
2445854

Abstract

The local inflammatory response to exogenous or endogenous agents is regulated by various humoral factors. Amongst these, the cytokines represent a prominent group to which belong not only cytotoxins, chemotactic factors, and cellular growth factors, but also the interferons. Evidence is reviewed indicating that, at the local level, interferon-gamma (IFN-gamma) constitutes a positive factor triggering or promoting the inflammatory response. Studies employing monoclonal antibodies against IFN-gamma indicate that inflammatory agents, such as bacterial endotoxin, induce local production of IFN-gamma, which acts as an up-regulator of the primary phase of the inflammatory response. Antibodies against IFN-alpha/beta, on the contrary, have so far not been found to affect inflammation. Systemic interferons, on the other hand, seem to fulfil a down-regulating role, as evidenced by the observation that exogenously administered IFN-alpha, -beta, and -gamma inhibit local inflammation.

Journal

Journal of interferon researchPubmed

Published: Jan 21, 1988

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