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Mathematical model of the first wave of Plasmodium falciparum asexual parasitemia in non-immune and vaccinated individuals.

Mathematical model of the first wave of Plasmodium falciparum asexual parasitemia in non-immune... We present a dynamic model of the highly pathogenic first wave of Plasmodium falciparum asexual parasitemia in non-immune persons. The model was successfully fitted to malaria therapy data. This required four case-specific parameters: the basic two-day multiplication factor, the time of onset of adaptive immunity, and the effective dose 50 densities for the innate and adaptive immune responses, respectively. All four parameters show large case-dependent variation that is mainly attributable to host factors. According to the model, the maximum value of the first wave is controlled mainly by the innate immune response. We used the model to explore the expected effects of vaccines targeting the parasite's asexual blood stages on the basis of what we consider to be the biologically most plausible assumptions concerning the parameter modifications induced by vaccination. According to our simulations, the benefit of antiparasitic vaccination is strongly host dependent and vaccine efficacy at low immunogenicity is much larger against severe disease than against fever. This has implications for the early testing of the protective efficacy of a vaccine in humans. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png The American journal of tropical medicine and hygiene Pubmed

Mathematical model of the first wave of Plasmodium falciparum asexual parasitemia in non-immune and vaccinated individuals.

The American journal of tropical medicine and hygiene , Volume 75 (2 Suppl): 10 – Sep 13, 2006

Mathematical model of the first wave of Plasmodium falciparum asexual parasitemia in non-immune and vaccinated individuals.


Abstract

We present a dynamic model of the highly pathogenic first wave of Plasmodium falciparum asexual parasitemia in non-immune persons. The model was successfully fitted to malaria therapy data. This required four case-specific parameters: the basic two-day multiplication factor, the time of onset of adaptive immunity, and the effective dose 50 densities for the innate and adaptive immune responses, respectively. All four parameters show large case-dependent variation that is mainly attributable to host factors. According to the model, the maximum value of the first wave is controlled mainly by the innate immune response. We used the model to explore the expected effects of vaccines targeting the parasite's asexual blood stages on the basis of what we consider to be the biologically most plausible assumptions concerning the parameter modifications induced by vaccination. According to our simulations, the benefit of antiparasitic vaccination is strongly host dependent and vaccine efficacy at low immunogenicity is much larger against severe disease than against fever. This has implications for the early testing of the protective efficacy of a vaccine in humans.

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ISSN
0002-9637
DOI
10.4269/ajtmh.2006.75.46
pmid
16931815

Abstract

We present a dynamic model of the highly pathogenic first wave of Plasmodium falciparum asexual parasitemia in non-immune persons. The model was successfully fitted to malaria therapy data. This required four case-specific parameters: the basic two-day multiplication factor, the time of onset of adaptive immunity, and the effective dose 50 densities for the innate and adaptive immune responses, respectively. All four parameters show large case-dependent variation that is mainly attributable to host factors. According to the model, the maximum value of the first wave is controlled mainly by the innate immune response. We used the model to explore the expected effects of vaccines targeting the parasite's asexual blood stages on the basis of what we consider to be the biologically most plausible assumptions concerning the parameter modifications induced by vaccination. According to our simulations, the benefit of antiparasitic vaccination is strongly host dependent and vaccine efficacy at low immunogenicity is much larger against severe disease than against fever. This has implications for the early testing of the protective efficacy of a vaccine in humans.

Journal

The American journal of tropical medicine and hygienePubmed

Published: Sep 13, 2006

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