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- Publisher
- Science and Engineering Publishing Company
- Copyright
- Science and Engineering Publishing Company
- ISSN
- 2326-5728
- eISSN
- 2326-5744
Abstract
Selectivity studies of RNA: disulphide bond containing oligodeoxynucleotide duplexes using melting temperature (Tm) have been reported. The Tm data of the RNA/ DNA duplexes showed that duplex formed with disulphide bond containing oligodeoxynucleotide melted at higher temperature than that of RNA/ unmodified DNA duplex by 9.5o C. Even RNA /oligodeoxynucleotide with adjacent thiol groups formed more stable duplex compared to RNA/unmodified DNA duplex. Studies also showed that the selectivity of duplexes with disulphide bond was out performed duplexes with unmodified oligonucleotide.
Journal
Advances in Chemical Science – Science and Engineering Publishing Company
Published: Jun 1, 2013
Keywords: C-5 Thiopropyne Thymidine Substituted Oligonucleotides; Tm Studies; Selectivity; Disulphide Bond Containing Oligonucleotides