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3D Electro-Rotation of Single CellsSummary and Outlook

3D Electro-Rotation of Single Cells: Summary and Outlook CHAPTER 4 4.1 MAIN WORK Based on the basic structure of thick-electrode DEP, the multi-electrode composition of thick-elec- trode DEP was studied. A single-cell 3D rotation chip of “Armillary Sphere” was proposed and fabricated. The chip design combined with single-cell capture V-shape structure. The trap structure and the 3D rotation thick-electrode structure solve the problem of single-cell loading difficulty. Single-cell 3D rotation is achieved by applying different electrical signal configurations on the elec- trodes. Based on single-cell 3D rotation manipulation, single-cell electrical parameter measurement and 3D morphology reconstruction are realized. The reconstructed 3D morphology can be further used to extract the physical features of single cells, such as surface area, volume, and ellipsoid rate, providing a new operating platform for single-cell analysis. To realize the opto-electronic integration application of multi-electrode structure with thick-electrode DEP, a single-cell optical stretcher and electro-rotation chip was presented. On the basis of the single-cell electro-rotation chip, a dual-fiber optical stretcher was integrated for single cell capture and mechanical property measurement. The high-efficiency single-cell capture ensures the stable spatial position of the cells, and combined with electro-rotation, can perform single-cell mechanical and electrical characteristic parameters measurement on the same chip. Five types of cells were http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png

3D Electro-Rotation of Single CellsSummary and Outlook

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Publisher
Springer International Publishing
Copyright
© Springer Nature Switzerland AG 2020
ISBN
978-3-031-00538-1
Pages
79 –80
DOI
10.1007/978-3-031-01666-0_4
Publisher site
See Chapter on Publisher Site

Abstract

CHAPTER 4 4.1 MAIN WORK Based on the basic structure of thick-electrode DEP, the multi-electrode composition of thick-elec- trode DEP was studied. A single-cell 3D rotation chip of “Armillary Sphere” was proposed and fabricated. The chip design combined with single-cell capture V-shape structure. The trap structure and the 3D rotation thick-electrode structure solve the problem of single-cell loading difficulty. Single-cell 3D rotation is achieved by applying different electrical signal configurations on the elec- trodes. Based on single-cell 3D rotation manipulation, single-cell electrical parameter measurement and 3D morphology reconstruction are realized. The reconstructed 3D morphology can be further used to extract the physical features of single cells, such as surface area, volume, and ellipsoid rate, providing a new operating platform for single-cell analysis. To realize the opto-electronic integration application of multi-electrode structure with thick-electrode DEP, a single-cell optical stretcher and electro-rotation chip was presented. On the basis of the single-cell electro-rotation chip, a dual-fiber optical stretcher was integrated for single cell capture and mechanical property measurement. The high-efficiency single-cell capture ensures the stable spatial position of the cells, and combined with electro-rotation, can perform single-cell mechanical and electrical characteristic parameters measurement on the same chip. Five types of cells were

Published: Jan 1, 2020

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