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James Fett, Daniel Strydom, Roy Lobb, E. Alderman, J. Bethune, James Riordan, Bert Vallee (1985)
Isolation and characterization of angiogenin, an angiogenic protein from human carcinoma cells.Biochemistry, 24 20
M. Klagsbrun, Y. Shing (1985)
Heparin affinity of anionic and cationic capillary endothelial cell growth factors: analysis of hypothalamus-derived growth factors and fibroblast growth factors.Proceedings of the National Academy of Sciences of the United States of America, 82 3
R. Lobb, J. Sasse, R. Sullivan, Y. Shing, P. D’Amore, J. Jacobs, M. Klagsbrun (1986)
Purification and characterization of heparin-binding endothelial cell growth factors.The Journal of biological chemistry, 261 4
W. Risau (1996)
What, if anything, is an angiogenic factor?Cancer and Metastasis Reviews, 15
D. Strydom, J. Fett, R. Lobb, E. Alderman, J. Bethune, J. Riordan, B. Vallée (1985)
Amino acid sequence of human tumor derived angiogenin.Biochemistry, 24 20
Y. Shing, J. Folkman, R. Sullivan, C. Butterfield, J. Murray, M. Klagsbrun (1984)
Heparin affinity: purification of a tumor-derived capillary endothelial cell growth factor.Science, 223 4642
Alain Schreiber, John Kenney, Joseph Kowalski, Kenneth Thomas, Guillermo Giménez-Gallego, M. Rios-Candelore, Jerry Di, Denis Barritault, J. Courty, Yves Courtois, Michel Moenner, Camille Loret, Wilson Burgess, Tevle Mehlman, R. Friesel, Warren Johnson, Thomas Maclag (1985)
A unique family of endothelial cell polypeptide mitogens: the antigenic and receptor cross-reactivity of bovine endothelial cell growth factor, brain-derived acidic fibroblast growth factor, and eye-derived growth factor-IIThe Journal of Cell Biology, 101
M. Klagsbrun, R. Sullivan, S. Smith, R. Rybka, Y. Shing (1987)
Purification of endothelial cell growth factors by heparin affinity chromatography.Methods in enzymology, 147
[The work of Judah Folkman indicated that one or more factors produced by a tumor could stimulate angiogenesis. These factors were called tumor angiogenesis factors (TAFs), and various laboratories set out to identify these TAFs. The problem was that even if the culture medium or the extracts of the tumor cells or of other tissues showed an important stimulatory activity for endothelial cells, the responsible factors could not be efficiently purified. This changed with the discovery that these factors had a strong affinity for heparin. Using heparin-sepharose chromatography, Michael Klagsbrun and Jay Shin from the Judah Folkman laboratory, and researchers from several other laboratories, were able to isolate these factors—which were called heparin-binding growth factors—and to determine their amino acid sequences [114–116] (Fig. 6.1).]
Published: Apr 14, 2018
Keywords: Tumor Angiogenesis Factor (TAFs); heparin-Sepharose Chromatography; Werner Risau; Vascular Endothelial Growth Factor; Heparin-binding Proteins
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