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[This chapter discusses the essential terms and concepts pertaining to how the body processes drugs. This subset of pharmacology is known as pharmacokinetics.]
Published: May 7, 2013
Keywords: Pharmacokinetics; Pharmacodynamics; Distribution; Metabolism; Excretion; Bioavailability; Hepatic extraction; Morphine; Absorption; Transporters; P-glycoprotein; P-gp; Organic anion-transporting peptide; OATP; Efflux transporter; Grapefruit juice; Fexofenadine CYP3A4; Substrate; Inducer; Inhibitor; Midazolam; Plasma concentration; Peak concentration; Trough; Volume of distribution; Warfarin; Protein binding; Digoxin; Albumin; Free fraction; Unbound fraction; Liver failure; Nephrotic syndrome; Heart failure; Phase I metabolism; Phase II metabolism; Oxidation; Reduction; Hydrolysis; Steroid hormones; Cytochrome; CYP450; Cytochrome; P450; CYP; 3A5; 3A7; 2C9; 2D6; Conjugation; Glucuronidation; Competitive inhibition; CYP3A5; CYP3A7; Clarithromycin; Itraconazole; Ketoconazole; Rifampin; Carbamazepine; St. John’s wort; Carbamazepine; Valproic acid; CYP2C9; Prodrug; CYP2D6; Tamoxifen; Endoxifen; Venlafaxine; Sertraline; Citalopram; Fluoxetine; Paroxetine; Pharmacogenomics; Poor metabolizer; Intermediate metabolizer; Extensive metabolizer; Ultra-rapid metabolizer; Beta-blocker; Metoprolol; Carvedilol; Codeine; Total drug clearance; Famotidine; Glomerular filtration rate; Creatinine clearance; Cockcroft-Gault formula; Modification of Diet in Renal Disease formula; Probenicid; Penicillin; First-order kinetics; Zero-order kinetics; Context-sensitive half-time
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