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[This chapter discusses the genetics, metabolic actions, substrates, inducers, and inhibitors of cytochrome P450 3A4.]
Published: May 7, 2013
Keywords: Cytochrome P450; CYP; P450; 3A4; CYP3A4; Pharmacokinetic; Metabolism; Metabolic pathway; Enzyme; Induction; Inhibitor; Substrate; Oxidase; Mixed-function oxidase; Liver; Intestine; Hepatocytes; Enterocytes; Chromosome; Gene locus; 7q21.3-7q22.1; MDR gene; Multi-drug resistance; P-glycoprotein; Pregname X receptor; PXR receptor; Constitutive androstane receptor; CAR receptor; Vitamin D; Vitamin D response; Polymorphism; Aliphatic oxidation; Aromatic hydroxylation; N-dealkylation; O-demethylation; Oxidative deamination; Sulfoxide formation; N-hydroxylation; Felodipine; Tertiary amine tricyclic anti-depressants; Antipsychotics; Macrolide antibiotics; Dihydropyridine calcium-channel blockers; HMG CoA reductase inhibitors; Statins; Carbamazepine; Steroid compounds; Protease inhibitors; Ritonavir; Anticonvulsants; Rifampin; St. John’s Wort; SSRI’s; Quinolone antibiotics; Azole antifungals; Grapefruit juices; Bergamottin; Dihydroxybergamottin; Torsade de pointes; Rhabdomyolysis; Midazolam; Rifampin; Intraconazole; Midazolam; Ketamine; Fentanyl; Alfentanil; Sufentanil; Methadone; Local anesthetics; Lidocaine; Bupivacaine; Ketamine; Methadone
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