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A Case Approach to Perioperative Drug-Drug InteractionsCYP3A4: The Workhorse

A Case Approach to Perioperative Drug-Drug Interactions: CYP3A4: The Workhorse [This chapter discusses the genetics, metabolic actions, substrates, inducers, and inhibitors of cytochrome P450 3A4.] http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png

A Case Approach to Perioperative Drug-Drug InteractionsCYP3A4: The Workhorse

Editors: Marcucci, Catherine; Hutchens, Michael P.; Wittwer, Erica D.; Weingarten, Toby N.; Sprung, Juraj; Nicholson, Wayne T.; Lalwani, Kirk; Metro, David G.; Dull, Randal O.; Swide, Christopher E.; Seagull, F. Jacob; Kirsch, Jeffrey R.; Sandson, Neil B.

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References (11)

Publisher
Springer New York
Copyright
© Springer Science+Business Media New York 2015
ISBN
978-1-4614-7494-4
Pages
37 –40
DOI
10.1007/978-1-4614-7495-1_7
Publisher site
See Chapter on Publisher Site

Abstract

[This chapter discusses the genetics, metabolic actions, substrates, inducers, and inhibitors of cytochrome P450 3A4.]

Published: May 7, 2013

Keywords: Cytochrome P450; CYP; P450; 3A4; CYP3A4; Pharmacokinetic; Metabolism; Metabolic pathway; Enzyme; Induction; Inhibitor; Substrate; Oxidase; Mixed-function oxidase; Liver; Intestine; Hepatocytes; Enterocytes; Chromosome; Gene locus; 7q21.3-7q22.1; MDR gene; Multi-drug resistance; P-glycoprotein; Pregname X receptor; PXR receptor; Constitutive androstane receptor; CAR receptor; Vitamin D; Vitamin D response; Polymorphism; Aliphatic oxidation; Aromatic hydroxylation; N-dealkylation; O-demethylation; Oxidative deamination; Sulfoxide formation; N-hydroxylation; Felodipine; Tertiary amine tricyclic anti-depressants; Antipsychotics; Macrolide antibiotics; Dihydropyridine calcium-channel blockers; HMG CoA reductase inhibitors; Statins; Carbamazepine; Steroid compounds; Protease inhibitors; Ritonavir; Anticonvulsants; Rifampin; St. John’s Wort; SSRI’s; Quinolone antibiotics; Azole antifungals; Grapefruit juices; Bergamottin; Dihydroxybergamottin; Torsade de pointes; Rhabdomyolysis; Midazolam; Rifampin; Intraconazole; Midazolam; Ketamine; Fentanyl; Alfentanil; Sufentanil; Methadone; Local anesthetics; Lidocaine; Bupivacaine; Ketamine; Methadone

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