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A Clinician's Guide to Pemphigus VulgarisOverview of Pemphigus Vulgaris

A Clinician's Guide to Pemphigus Vulgaris: Overview of Pemphigus Vulgaris [Pemphigus is originated from the Greek word pemphix meaning bubble or blister. Pemphigus vulgaris (PV) is a life-threatening chronic autoimmune disease where the serum autoantibodies respond to the cell surface antigens resulting in a loss of epidermal cell cohesion. This can be characterized as the manifestation of circulating autoantibodies against the intercellular adhesion structures, desmosomal protein desmoglein (DSG) 3, and in some cases DSG1. However, there is accumulating evidence that indicates that pemphigus vulgaris also targets other, nondesmoglein, molecules. The functional role of these other specificities and their impact on disease expression are yet to be fully elucidated.] http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png

A Clinician's Guide to Pemphigus VulgarisOverview of Pemphigus Vulgaris

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Publisher
Springer International Publishing
Copyright
© Springer International Publishing AG 2018
ISBN
978-3-319-67758-3
Pages
11 –12
DOI
10.1007/978-3-319-67759-0_2
Publisher site
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Abstract

[Pemphigus is originated from the Greek word pemphix meaning bubble or blister. Pemphigus vulgaris (PV) is a life-threatening chronic autoimmune disease where the serum autoantibodies respond to the cell surface antigens resulting in a loss of epidermal cell cohesion. This can be characterized as the manifestation of circulating autoantibodies against the intercellular adhesion structures, desmosomal protein desmoglein (DSG) 3, and in some cases DSG1. However, there is accumulating evidence that indicates that pemphigus vulgaris also targets other, nondesmoglein, molecules. The functional role of these other specificities and their impact on disease expression are yet to be fully elucidated.]

Published: Nov 27, 2017

Keywords: Pemphigus vulgaris; Desmoglein; Mucocutaneous variant; Mucosal dominant variant; Cutaneous-only PV

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