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A Clinician's Guide to Systemic Effects of Periodontal DiseasesPathogenesis of Periodontal Diseases

A Clinician's Guide to Systemic Effects of Periodontal Diseases: Pathogenesis of Periodontal... [Our understanding of the pathogenesis of periodontal diseases has greatly progressed over the past three decades. Beginning with the observation that periodontal diseases are associated with the presence of a bacterial plaque or biofilm, our understanding has evolved to the realization that specific bacterial profiles exist within dental biofilms in association with specific periodontal diseases. This understanding has in turn led to the emerging concept of immune subversion of the host by periodontal pathogens with the attendant conversion of the periodontal biofilm/host relationship from one of a symbiosis in health to a dysbiosis in disease. Currently, periodontitis is viewed as a polymicrobial, complex disease that shares several characteristics with other complex diseases including atherosclerosis, diabetes mellitus, and Alzheimer’s disease. We presently recognize that individuals vary greatly in disease susceptibility and that host genetic factors play a significant, although currently largely unspecified, role in determining disease susceptibility. Therefore, to provide an understanding of periodontal diseases for the chapters that follow, this chapter will present an overview of our current understanding of the pathogenesis of periodontal diseases with the aim of providing a conceptual framework to help address how a common oral inflammatory disease can contribute to the wide array of systemic diseases and conditions described in this book.] http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png

A Clinician's Guide to Systemic Effects of Periodontal DiseasesPathogenesis of Periodontal Diseases

Editors: Craig, Ronald G.; Kamer, Angela R.
Craig, Ronald G.
A Clinician's Guide to Systemic Effects of Periodontal Diseases — May 18, 2016
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References (27)

Publisher
Springer Berlin Heidelberg
Copyright
© Springer-Verlag Berlin Heidelberg 2016
ISBN
978-3-662-49697-8
Pages
5 –18
DOI
10.1007/978-3-662-49699-2_2
Publisher site
See Chapter on Publisher Site

Abstract

[Our understanding of the pathogenesis of periodontal diseases has greatly progressed over the past three decades. Beginning with the observation that periodontal diseases are associated with the presence of a bacterial plaque or biofilm, our understanding has evolved to the realization that specific bacterial profiles exist within dental biofilms in association with specific periodontal diseases. This understanding has in turn led to the emerging concept of immune subversion of the host by periodontal pathogens with the attendant conversion of the periodontal biofilm/host relationship from one of a symbiosis in health to a dysbiosis in disease. Currently, periodontitis is viewed as a polymicrobial, complex disease that shares several characteristics with other complex diseases including atherosclerosis, diabetes mellitus, and Alzheimer’s disease. We presently recognize that individuals vary greatly in disease susceptibility and that host genetic factors play a significant, although currently largely unspecified, role in determining disease susceptibility. Therefore, to provide an understanding of periodontal diseases for the chapters that follow, this chapter will present an overview of our current understanding of the pathogenesis of periodontal diseases with the aim of providing a conceptual framework to help address how a common oral inflammatory disease can contribute to the wide array of systemic diseases and conditions described in this book.]

Published: May 18, 2016

Keywords: Chronic Periodontitis; Periodontal Pocket; Periodontal Health; Host Inflammatory Response; Aggressive Periodontitis

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