Access the full text.
Sign up today, get DeepDyve free for 14 days.
Loading next page...
/lp/springer-journals/a-clinician-s-guide-to-systemic-effects-of-periodontal-diseases-D9PRo0X0rB
- Publisher
- Springer Berlin Heidelberg
- Copyright
- © Springer-Verlag Berlin Heidelberg 2016
- ISBN
- 978-3-662-49697-8
- Pages
- 5 –18
- DOI
- 10.1007/978-3-662-49699-2_2
- Publisher site
- See Chapter on Publisher Site
Abstract
[Our understanding of the pathogenesis of periodontal diseases has greatly progressed over the past three decades. Beginning with the observation that periodontal diseases are associated with the presence of a bacterial plaque or biofilm, our understanding has evolved to the realization that specific bacterial profiles exist within dental biofilms in association with specific periodontal diseases. This understanding has in turn led to the emerging concept of immune subversion of the host by periodontal pathogens with the attendant conversion of the periodontal biofilm/host relationship from one of a symbiosis in health to a dysbiosis in disease. Currently, periodontitis is viewed as a polymicrobial, complex disease that shares several characteristics with other complex diseases including atherosclerosis, diabetes mellitus, and Alzheimer’s disease. We presently recognize that individuals vary greatly in disease susceptibility and that host genetic factors play a significant, although currently largely unspecified, role in determining disease susceptibility. Therefore, to provide an understanding of periodontal diseases for the chapters that follow, this chapter will present an overview of our current understanding of the pathogenesis of periodontal diseases with the aim of providing a conceptual framework to help address how a common oral inflammatory disease can contribute to the wide array of systemic diseases and conditions described in this book.]
Published: May 18, 2016
Keywords: Chronic Periodontitis; Periodontal Pocket; Periodontal Health; Host Inflammatory Response; Aggressive Periodontitis