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A Comprehensive Guide to Core Needle Biopsies of the Breast Adenosis, Sclerosing Lesions, Microglandular Adenosis, and Mucocele-Like Lesions

A Comprehensive Guide to Core Needle Biopsies of the Breast : Adenosis, Sclerosing Lesions,... [Sclerosing adenosis, sclerosing lesions, microglandular adenosis, and mucocele-like lesions are benign lesions that may mimic invasive carcinoma on routine histology. Adenosis and sclerosing lesions are small glandular proliferations that may resemble well-differentiated invasive ductal or tubular carcinoma, whereas mucocele-like lesions may be confused with mucinous carcinoma. It may be especially difficult to recognize these lesions in the limited core needle biopsy sample, and therefore, it is important to maintain a low threshold for diagnostic work-up. Immunohistochemical studies for myoepithelial cell markers facilitate the correct diagnosis in challenging cases. However, a notable exception, microglandular adenosis, lacks myoepithelial cells, and must be distinguished from well-differentiated invasive carcinoma by its S-100 protein immunoreactivity and triple negative phenotype.] http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png

A Comprehensive Guide to Core Needle Biopsies of the Breast Adenosis, Sclerosing Lesions, Microglandular Adenosis, and Mucocele-Like Lesions

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Publisher
Springer International Publishing
Copyright
© Springer International Publishing Switzerland 2016
ISBN
978-3-319-26289-5
Pages
161 –193
DOI
10.1007/978-3-319-26291-8_5
Publisher site
See Chapter on Publisher Site

Abstract

[Sclerosing adenosis, sclerosing lesions, microglandular adenosis, and mucocele-like lesions are benign lesions that may mimic invasive carcinoma on routine histology. Adenosis and sclerosing lesions are small glandular proliferations that may resemble well-differentiated invasive ductal or tubular carcinoma, whereas mucocele-like lesions may be confused with mucinous carcinoma. It may be especially difficult to recognize these lesions in the limited core needle biopsy sample, and therefore, it is important to maintain a low threshold for diagnostic work-up. Immunohistochemical studies for myoepithelial cell markers facilitate the correct diagnosis in challenging cases. However, a notable exception, microglandular adenosis, lacks myoepithelial cells, and must be distinguished from well-differentiated invasive carcinoma by its S-100 protein immunoreactivity and triple negative phenotype.]

Published: Sep 17, 2016

Keywords: Sclerosing adenosis; Apocrine adenosis; Radial scar; Complex sclerosing lesion; Microglandular adenosis; Mucocele-like lesion

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