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A facile and eco-friendly fluorometric method for the determination of methotrexate and folic acid in biological samples based on hollow luminescent carbon dots and chemometrics method

A facile and eco-friendly fluorometric method for the determination of methotrexate and folic... A rapid, simple, and inexpensive spectrofluorimetric sensor has been developed for the simultaneous determination of methotrexate (MTX) and folic acid (FA) based on their interactions with hollow carbon dots (HCDs). Since the use of folic acid to cope with the toxic side effects of MTX in patients is essential, the simultaneous determination of these two compounds has been interesting. The results showed that  MTX could quench the fluorescence of HCDs with a dynamic quenching mechanism. The sensor exhibited a linear concentration range of 1.0 × 10–6–1.9 × 10–4 mol L−1 for MTX and 1.5 × 10–5–9.4 × 10–4 mol L−1 for FA and the obtained detection limits for MTX and FA were 1.6 × 10–7 and 5.0 × 10–7 mol L−1, respectively. The applicability of the method was investigated in the analysis of the urine samples and the partial least squares (PLS) method was used for the simultaneous determination of MTX and FA.Graphical abstract[graphic not available: see fulltext] http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Analytical Sciences Springer Journals

A facile and eco-friendly fluorometric method for the determination of methotrexate and folic acid in biological samples based on hollow luminescent carbon dots and chemometrics method

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References (31)

Publisher
Springer Journals
Copyright
Copyright © The Author(s), under exclusive licence to The Japan Society for Analytical Chemistry 2023. Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.
ISSN
0910-6340
eISSN
1348-2246
DOI
10.1007/s44211-023-00360-2
Publisher site
See Article on Publisher Site

Abstract

A rapid, simple, and inexpensive spectrofluorimetric sensor has been developed for the simultaneous determination of methotrexate (MTX) and folic acid (FA) based on their interactions with hollow carbon dots (HCDs). Since the use of folic acid to cope with the toxic side effects of MTX in patients is essential, the simultaneous determination of these two compounds has been interesting. The results showed that  MTX could quench the fluorescence of HCDs with a dynamic quenching mechanism. The sensor exhibited a linear concentration range of 1.0 × 10–6–1.9 × 10–4 mol L−1 for MTX and 1.5 × 10–5–9.4 × 10–4 mol L−1 for FA and the obtained detection limits for MTX and FA were 1.6 × 10–7 and 5.0 × 10–7 mol L−1, respectively. The applicability of the method was investigated in the analysis of the urine samples and the partial least squares (PLS) method was used for the simultaneous determination of MTX and FA.Graphical abstract[graphic not available: see fulltext]

Journal

Analytical Sciences – Springer Journals

Published: Sep 1, 2023

Keywords: Hollow carbon dots; Fluorescence detection; Methotrexate; Folic acid; Partial least square

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