Get 20M+ Full-Text Papers For Less Than $1.50/day. Start a 14-Day Trial for You or Your Team.

Learn More →

A Handbook of Transcription FactorsHow Transcription Factors Identify Regulatory Sites in Genomic Sequence

A Handbook of Transcription Factors: How Transcription Factors Identify Regulatory Sites in... [Binding of transcription factors to functional sites is a fundamental step in transcriptional regulation. In this chapter, we discuss how transcription factors are thought to achieve specificity to their functional targets, despite their typically low concentrations and degenerate binding specificities, and the fact that in large genomes their functional binding sites must compete with their widespread alternative binding sites. We highlight the importance of the chromatin structure context of the binding sites in this process, and its dependency on the genomic DNA sequence.] http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png

A Handbook of Transcription FactorsHow Transcription Factors Identify Regulatory Sites in Genomic Sequence

Part of the Subcellular Biochemistry Book Series (volume 52)
Editors: Hughes, Timothy R.

Loading next page...
 
/lp/springer-journals/a-handbook-of-transcription-factors-how-transcription-factors-identify-vMHP5KXb20
Publisher
Springer Netherlands
Copyright
© Springer Science+Business Media B.V. 2011
ISBN
978-90-481-9068-3
Pages
193 –204
DOI
10.1007/978-90-481-9069-0_9
Publisher site
See Chapter on Publisher Site

Abstract

[Binding of transcription factors to functional sites is a fundamental step in transcriptional regulation. In this chapter, we discuss how transcription factors are thought to achieve specificity to their functional targets, despite their typically low concentrations and degenerate binding specificities, and the fact that in large genomes their functional binding sites must compete with their widespread alternative binding sites. We highlight the importance of the chromatin structure context of the binding sites in this process, and its dependency on the genomic DNA sequence.]

Published: Apr 14, 2011

Keywords: Motifs; Nucleosomes; Transcription factors; Modeling; Histone H1

There are no references for this article.