Access the full text.
Sign up today, get DeepDyve free for 14 days.
G. Francis, Elisabeth Fayard, F. Picard, J. Auwerx (2003)
Nuclear receptors and the control of metabolism.Annual review of physiology, 65
F. Sladek (2011)
What are nuclear receptor ligands?Molecular and Cellular Endocrinology, 334
Hyun Kim, G. Casadesus (2010)
Estrogen-mediated effects on cognition and synaptic plasticity: what do estrogen receptor knockout models tell us?Biochimica et biophysica acta, 1800 10
L. Partridge, D. Gems (2002)
Mechanisms of aging: public or private?Nature Reviews Genetics, 3
E. Walker, V. Mittal, K. Tessner (2008)
Stress and the hypothalamic pituitary adrenal axis in the developmental course of schizophrenia.Annual review of clinical psychology, 4
L. Altucci, H. Gronemeyer (2001)
Nuclear receptors in cell life and deathTrends in Endocrinology & Metabolism, 12
J. Schwabe, S. Teichmann (2004)
Nuclear Receptors: The Evolution of DiversityScience's STKE, 2004
A. Bao, G. Meynen, D. Swaab (2008)
The stress system in depression and neurodegeneration: Focus on the human hypothalamusBrain Research Reviews, 57
S. Ramakrishnan, G. Muscat (2006)
The orphan Rev-erb nuclear receptors: a link between metabolism, circadian rhythm and inflammation?Nuclear Receptor Signaling, 4
Michèle Teboul, A. Gréchez-Cassiau, Fabienne Guillaumond, Franck Delaunay (2009)
How nuclear receptors tell time.Journal of applied physiology, 107 6
V. Arulampalam, Gediminas Greicius, S. Pettersson (2006)
The long and winding road to gut homeostasisCurrent Opinion in Gastroenterology, 22
A. Erol (2007)
The Functions of PPARs in Aging and LongevityPPAR Research, 2007
K. Katsuyama, M. Shichiri, F. Marumo, Y. Hirata (1998)
NO Inhibits Cytokine-Induced iNOS Expression and NF-κB Activation by Interfering With Phosphorylation and Degradation of IκB-αArteriosclerosis, Thrombosis, and Vascular Biology, 18
Salvatore Toma, L. Isnardi, L. Riccardi, Werner Bollag (1998)
Induction of apoptosis in MCF-7 breast carcinoma cell line by RAR and RXR selective retinoids.Anticancer research, 18 2A
J. Jiang, E. Jaruga, M. Repnevskaya, S. Jazwinski (2000)
An intervention resembling caloric restriction prolongs life span and retards aging in yeastThe FASEB Journal, 14
P. Germain, B. Staels, C. Dacquet, M. Spedding, V. Laudet (2006)
Overview of Nomenclature of Nuclear ReceptorsPharmacological Reviews, 58
L. Sage (2007)
Fountain of youthNature Physics, 3
K. Nettles, J. Bruning, G. Gil, Erin O'Neill, J. Nowak, Alun Hughs, Younchang Kim, E. Desombre, Robert Dilis, R. Hanson, A. Joachimiak, G. Greene (2007)
Structural plasticity in the oestrogen receptor ligand‐binding domainEMBO reports, 8
L. Yin, Jing Wang, P. Klein, M. Lazar (2006)
Nuclear Receptor Rev-erbα Is a Critical Lithium-Sensitive Component of the Circadian ClockScience, 311
S. Baek, M. Rosenfeld (2004)
Nuclear receptor coregulators: their modification codes and regulatory mechanism by translocation.Biochemical and biophysical research communications, 319 3
N. Noy (2007)
Ligand specificity of nuclear hormone receptors: sifting through promiscuity.Biochemistry, 46 47
H. Duez, Bart Staels (2009)
Rev-erb-α: an integrator of circadian rhythms and metabolismJournal of Applied Physiology, 107
T. Burris (2008)
Nuclear hormone receptors for heme: REV-ERBalpha and REV-ERBbeta are ligand-regulated components of the mammalian clock.Molecular endocrinology, 22 7
M. Baker (2004)
Co-evolution of steroidogenic and steroid-inactivating enzymes and adrenal and sex steroid receptorsMolecular and Cellular Endocrinology, 215
M. Warner, J. Gustafsson (2010)
The role of estrogen receptor beta (ERbeta) in malignant diseases--a new potential target for antiproliferative drugs in prevention and treatment of cancer.Biochemical and biophysical research communications, 396 1
M. Horner, Keith Pardee, Suya Liu, K. King-Jones, G. Lajoie, A. Edwards, H. Krause, C. Thummel (2009)
The Drosophila DHR96 nuclear receptor binds cholesterol and regulates cholesterol homeostasis.Genes & development, 23 23
H. Escrivá, F. Delaunay, V. Laudet (2000)
Ligand binding and nuclear receptor evolutionBioEssays, 22
A. Näär, J. Thakur (2009)
Nuclear receptor-like transcription factors in fungi.Genes & development, 23 4
G. Tocchini-Valentini, N. Rochel, H. Escrivá, P. Germain, C. Peluso‐Iltis, Mathilde Paris, Sarah Sanglier‐Cianférani, A. Dorsselaer, D. Moras, V. Laudet (2009)
Structural and Functional Insights into the Ligand-binding Domain of a Nonduplicated Retinoid X Nuclear Receptor from the Invertebrate Chordate Amphioxus*Journal of Biological Chemistry, 284
A. Bakrim, A. Maria, F. Sayah, R. Lafont, N. Takvorian (2008)
Ecdysteroids in spinach (Spinacia oleracea L.): biosynthesis, transport and regulation of levels.Plant physiology and biochemistry : PPB, 46 10
M. Heneka, G. Landreth (2007)
PPARs in the brain.Biochimica et biophysica acta, 1771 8
P. Lefebvre, B. Cariou, F. Lien, F. Kuipers, B. Staels (2009)
Role of bile acids and bile acid receptors in metabolic regulation.Physiological reviews, 89 1
S. Ramagopalan, A. Heger, A. Berlanga, N. Maugeri, M. Lincoln, Amy Burrell, L. Handunnetthi, A. Handel, G. Disanto, S. Orton, C. Watson, J. Morahan, G. Giovannoni, C. Ponting, G. Ebers, J. Knight (2010)
A ChIP-seq defined genome-wide map of vitamin D receptor binding: associations with disease and evolution.Genome research, 20 10
A. Azoitei, M. Spindler‐Barth (2009)
DNA affects ligand binding of the ecdysone receptor of Drosophila melanogasterMolecular and Cellular Endocrinology, 303
L. Yin, Nan Wu, J. Curtin, M. Qatanani, Nava Szwergold, R. Reid, G. Waitt, D. Parks, K. Pearce, G. Wisely, M. Lazar (2007)
Rev-erbα, a Heme Sensor That Coordinates Metabolic and Circadian PathwaysScience, 318
M. Gottlicher, Eva WIDMARKt, Li Qiao, Jan-Åke Gustafsson (1992)
Fatty acids activate a chimera of the clofibric acid-activated receptor and the glucocorticoid receptor.Proceedings of the National Academy of Sciences of the United States of America, 89
B. Katzenellenbogen, I. Choi, R. Delage-Mourroux, T. Ediger, P. Martini, M. Montano, Jun Sun, Karen Weis, J. Katzenellenbogen (2000)
Molecular mechanisms of estrogen action: selective ligands and receptor pharmacologyThe Journal of Steroid Biochemistry and Molecular Biology, 74
D. Mangelsdorf, C. Thummel, M. Beato, P. Herrlich, G. Schütz, K. Umesono, B. Blumberg, P. Kastner, M. Mark, P. Chambon, R. Evans (1995)
The nuclear receptor superfamily: The second decadeCell, 83
Stéphanie Bertrand, F. Brunet, H. Escrivá, Gilles Parmentier, V. Laudet, M. Robinson-Rechavi (2004)
Evolutionary genomics of nuclear receptors: from twenty-five ancestral genes to derived endocrine systems.Molecular biology and evolution, 21 10
Neil Clarke, Jeremy Berg (1998)
Zinc fingers in Caenorhabditis elegans: finding families and probing pathways.Science, 282 5396
S. Fiorucci, S. Cipriani, A. Mencarelli, B. Renga, E. Distrutti, F. Baldelli (2010)
Counter-regulatory role of bile acid activated receptors in immunity and inflammation.Current molecular medicine, 10 6
P. Rogers, L. Ying, T. Burris (2008)
Relationship between circadian oscillations of Rev-erbalpha expression and intracellular levels of its ligand, heme.Biochemical and biophysical research communications, 368 4
G. Hammer, I. Krylova, Yixian Zhang, B. Darimont, Kimberly Simpson, N. Weigel, H. Ingraham (1999)
Phosphorylation of the nuclear receptor SF-1 modulates cofactor recruitment: integration of hormone signaling in reproduction and stress.Molecular cell, 3 4
L. Riddiford, J. Truman (1993)
Hormone receptors and the regulation of insect metamorphosis.Receptor, 3 3
H. Gronemeyer, J. Gustafsson, V. Laudet (2004)
Principles for modulation of the nuclear receptor superfamilyNature Reviews Drug Discovery, 3
L. Nagy, J. Schwabe (2004)
Mechanism of the nuclear receptor molecular switch.Trends in biochemical sciences, 29 6
Lauretta Grasso, D. Hayward, John Trueman, Kate Hardie, Peter Janssens, Eldon Ball (2001)
The evolution of nuclear receptors: evidence from the coral Acropora.Molecular phylogenetics and evolution, 21 1
Zhihong Lin, Scott Reierstad, Chiang-Ching Huang, S. Bulun (2007)
Novel estrogen receptor-alpha binding sites and estradiol target genes identified by chromatin immunoprecipitation cloning in breast cancer.Cancer research, 67 10
J. Adler, R. Grebenok (1999)
Occurrence, biosynthesis, and putative role of ecdysteroids in plants.Critical reviews in biochemistry and molecular biology, 34 4
E. Woo, D. Jeong, Mi-Youn Lim, Seung Kim, Kyung‐Jin Kim, Sei-Mee Yoon, Byoung Park, S. Ryu (2007)
Structural insight into the constitutive repression function of the nuclear receptor Rev-erbbeta.Journal of molecular biology, 373 3
Kunal Agrawal, S. Onami, J. Mortimer, S. Pal (2010)
Cognitive changes associated with endocrine therapy for breast cancer.Maturitas, 67 3
T. Chapman, L. Partridge (1996)
Female fitness in Drosophila melanogaster: an interaction between the effect of nutrition and of encounter rate with malesProceedings of the Royal Society of London. Series B: Biological Sciences, 263
E. Thompson, Raj Kumar (2003)
DNA binding of nuclear hormone receptors influences their structure and function.Biochemical and biophysical research communications, 306 1
J. Chung, Arnold Seo, Sang Chung, M. Kim, C. Leeuwenburgh, B. Yu, H. Chung (2008)
Molecular mechanism of PPAR in the regulation of age-related inflammationAgeing Research Reviews, 7
J. Buell, B. Dawson-Hughes (2008)
Vitamin D and neurocognitive dysfunction: preventing "D"ecline?Molecular aspects of medicine, 29 6
Nancy Urizar, Amy Liverman, D. Dodds, F. Silva, P. Ordentlich, Y. Yan, F. Gonzalez, R. Heyman, D. Mangelsdorf, D. Moore (2002)
A Natural Product That Lowers Cholesterol As an Antagonist Ligand for FXRScience, 296
Laura Palanker, A. Necakov, Heidi Sampson, Ruoyu Ni, Chunyi Hu, C. Thummel, H. Krause (2006)
Dynamic regulation of Drosophila nuclear receptor activity in vivo, 133
K. King-Jones, C. Thummel (2005)
Nuclear receptors — a perspective from DrosophilaNature Reviews Genetics, 6
R. Hardeland, A. Coto-Montes, B. Poeggeler (2003)
Circadian Rhythms, Oxidative Stress, and Antioxidative Defense MechanismsChronobiology International, 20
F. Grün, B. Blumberg (2006)
Environmental obesogens: organotins and endocrine disruption via nuclear receptor signaling.Endocrinology, 147 6 Suppl
H. Escrivá, Stéphanie Bertrand, V. Laudet (2004)
The evolution of the nuclear receptor superfamily.Essays in biochemistry, 40
B. Braeckman, Koen Houthoofd, J. Vanfleteren (2001)
Insulin-like signaling, metabolism, stress resistance and aging in Caenorhabditis elegansMechanisms of Ageing and Development, 122
J. Truman (1971)
Hour-glass behavior of the circadian clock controlling eclosion of the silkmoth Antheraea pernyi.Proceedings of the National Academy of Sciences of the United States of America, 68 3
R. Riggins, M. Mazzotta, Omar Maniya, R. Clarke (2010)
Orphan nuclear receptors in breast cancer pathogenesis and therapeutic response.Endocrine-related cancer, 17 3
M. Schräder, Michael Becker-André, Carsten Carlberg (1994)
Thyroid hormone receptor functions as monomeric ligand-induced transcription factor on octameric half-sites. Consequences also for dimerization.The Journal of biological chemistry, 269 9
C. Thummel, J. Chory (2002)
Steroid signaling in plants and insects--common themes, different pathways.Genes & development, 16 24
V. Perissi, Kristen Jepsen, C. Glass, M. Rosenfeld (2010)
Deconstructing repression: evolving models of co-repressor actionNature Reviews Genetics, 11
D. Gauchat, H. Escrivá, Marijana Miljkovic-Licina, S. Chera, M. Langlois, A. Bègue, V. Laudet, B. Galliot (2004)
The orphan COUP-TF nuclear receptors are markers for neurogenesis from cnidarians to vertebrates.Developmental biology, 275 1
J. Storch, A. Thumser (2000)
The fatty acid transport function of fatty acid-binding proteins.Biochimica et biophysica acta, 1486 1
B. Forman, Iphigenia Tzameli, Hueng-Sik Choi, Jasmine Chen, D. Simha, W. Seol, R. Evans, D. Moore (1998)
Androstane metabolites bind to and deactivate the nuclear receptor CAR-βNature, 395
B. Tu, S. McKnight (2006)
Metabolic cycles as an underlying basis of biological oscillationsNature Reviews Molecular Cell Biology, 7
H. Escrivá, R. Safi, C. Hänni, M. Langlois, P. Saumitou-Laprade, D. Stéhelin, A. Capron, R. Pierce, V. Laudet (1997)
Ligand binding was acquired during evolution of nuclear receptors.Proceedings of the National Academy of Sciences of the United States of America, 94 13
Sabine Schneider, Jon Marles-Wright, K. Sharp, M. Paoli (2007)
Diversity and conservation of interactions for binding heme in b-type heme proteins.Natural product reports, 24 3
H. Chong, A. Infante, Y. Seo, Tae-Il Jeon, Yanqiao Zhang, P. Edwards, Xiaohui Xie, T. Osborne (2010)
Genome-wide interrogation of hepatic FXR reveals an asymmetric IR-1 motif and synergy with LRH-1Nucleic Acids Research, 38
J. Thornton, Eleanor Need, D. Crews (2003)
Resurrecting the Ancestral Steroid Receptor: Ancient Origin of Estrogen SignalingScience, 301
C. Winterbourn (2008)
Reconciling the chemistry and biology of reactive oxygen species.Nature chemical biology, 4 5
I. Billas, T. Iwema, J. Garnier, A. Mitschler, N. Rochel, D. Moras (2003)
Structural adaptability in the ligand-binding pocket of the ecdysone hormone receptorNature, 426
A. Reitzel, A. Tarrant (2009)
Nuclear receptor complement of the cnidarian Nematostella vectensis: phylogenetic relationships and developmental expression patternsBMC Evolutionary Biology, 9
H. Migita, J. Morser, K. Kawai (2004)
Rev‐erbα upregulates NF‐κB‐responsive genes in vascular smooth muscle cellsFEBS Letters, 561
E. Swedenborg, Krista Power, Wen Cai, I. Pongratz, J. Rüegg (2009)
Regulation of estrogen receptor beta activity and implications in health and diseaseCellular and Molecular Life Sciences, 66
Taosheng Chen (2008)
Nuclear receptor drug discovery.Current opinion in chemical biology, 12 4
M. Paoli, J. Marles-Wright, Ann Smith (2002)
Structure-function relationships in heme-proteins.DNA and cell biology, 21 4
M. Wiens, R. Batel, M. Korzhev, W. Müller (2003)
Retinoid X receptor and retinoic acid response in the marine sponge Suberites domunculaJournal of Experimental Biology, 206
T. Wilson, T. Fahrner, J. Milbrandt (1993)
The orphan receptors NGFI-B and steroidogenic factor 1 establish monomer binding as a third paradigm of nuclear receptor-DNA interactionMolecular and Cellular Biology, 13
Pengxiang Huang*, V. Chandra, F. Rastinejad (2010)
Structural overview of the nuclear receptor superfamily: insights into physiology and therapeutics.Annual review of physiology, 72
M. Robinson-Rechavi, Anne-Sophie Carpentier, Marilyne Duffraisse, V. Laudet (2001)
How many nuclear hormone receptors are there in the human genome?Trends in genetics : TIG, 17 10
M. Haussler, C. Haussler, G. Whitfield, J. Hsieh, P. Thompson, T. Barthel, Leonid Bartik, J. Egan, Yifei Wu, Jana Kubicek, Christine Lowmiller, Eric Moffet, Ryan Forster, P. Jurutka (2010)
The nuclear vitamin D receptor controls the expression of genes encoding factors which feed the “Fountain of Youth” to mediate healthful agingThe Journal of Steroid Biochemistry and Molecular Biology, 121
C. Glass, K. Saijo (2010)
Nuclear receptor transrepression pathways that regulate inflammation in macrophages and T cellsNature Reviews Immunology, 10
J. Olefsky (2001)
Nuclear Receptor Minireview Series*The Journal of Biological Chemistry, 276
L. Ignarro (2000)
Nitric oxide : biology and pathobiology
S. Kızıldağ, H. Ateş, S. Kizildag (2009)
Treatment of K562 cells with 1,25-dihydroxyvitamin D3 induces distinct alterations in the expression of apoptosis-related genes BCL2, BAX, BCLXL, and p21Annals of Hematology, 89
C. Winterbourn, M. Hampton (2008)
Thiol chemistry and specificity in redox signaling.Free radical biology & medicine, 45 5
K. Yamagishi, Keiko Yamamoto, Y. Mochizuki, T. Nakano, S. Yamada, H. Tokiwa (2010)
Flexible ligand recognition of peroxisome proliferator-activated receptor-gamma (PPARgamma).Bioorganic & medicinal chemistry letters, 20 11
Naresh Kumar, L. Solt, Yongjun Wang, P. Rogers, G. Bhattacharyya, T. Kamenecka, K. Stayrook, Christine Crumbley, Z. Floyd, J. Gimble, P. Griffin, T. Burris (2010)
Regulation of adipogenesis by natural and synthetic REV-ERB ligands.Endocrinology, 151 7
J. Chrencik, J. Orans, L. Moore, Yu Xue, Li Peng, J. Collins, G. Wisely, M. Lambert, S. Kliewer, M. Redinbo (2005)
Structural disorder in the complex of human pregnane X receptor and the macrolide antibiotic rifampicin.Molecular endocrinology, 19 5
Les Burke, Michael Downes, Amanda Carozzi, Vincent Giguère, George scat (1996)
Transcriptional repression by the orphan steroid receptor RVR/Rev-erb beta is dependent on the signature motif and helix 5 in the E region: functional evidence for a biological role of RVR in myogenesis.Nucleic acids research, 24 18
Yang Li, Zhulun Wang, N. Furukawa, Patrick Escaron, Jennifer Weiszmann, Gary Lee, M. Lindstrom, Jinsong Liu, Xiaohong Liu, Haoda Xu, O. Plotnikova, Vidya Prasad, N. Walker, R. Learned, Jin-Long Chen (2008)
T2384, a Novel Antidiabetic Agent with Unique Peroxisome Proliferator-activated Receptor γ Binding Properties*Journal of Biological Chemistry, 283
P. Barnett, H. Tabak, E. Hettema (2000)
Nuclear receptors arose from pre-existing protein modules during evolution.Trends in biochemical sciences, 25 5
E. Chow, Bahram Razani, G. Cheng (2007)
Innate immune system regulation of nuclear hormone receptors in metabolic diseasesJournal of Leukocyte Biology, 82
G. Ferreyra, M. Cammarota, D. Golombek (1998)
Photic control of nitric oxide synthase activity in the hamster suprachiasmatic nucleiBrain Research, 797
Hitoshi Ueda, Guan-Cheng Sun, T. Murata, Susumu Hirose (1992)
A novel DNA-binding motif abuts the zinc finger domain of insect nuclear hormone receptor FTZ-F1 and mouse embryonal long terminal repeat-binding protein.Molecular and cellular biology, 12 12
A. Shiau, D. Barstad, P. Loria, Lin Cheng, P. Kushner, D. Agard, G. Greene (1998)
The Structural Basis of Estrogen Receptor/Coactivator Recognition and the Antagonism of This Interaction by TamoxifenCell, 95
Jianhua Yang, K. Kim, Andrew Lucas, Karen Drahos, Carlo Santos, Sean Mury, D. Capelluto, C. Finkielstein (2008)
A Novel Heme-Regulatory Motif Mediates Heme-Dependent Degradation of the Circadian Factor Period 2Molecular and Cellular Biology, 28
N. Potier, I. Billas, A. Steinmetz, C. Schaeffer, A. Dorsselaer, D. Moras, J. Renaud (2003)
Using nondenaturing mass spectrometry to detect fortuitous ligands in orphan nuclear receptorsProtein Science, 12
H. García, V. Laudet, M. Robinson-Rechavi (2004)
Nuclear receptors are markers of animal genome evolutionJournal of Structural and Functional Genomics, 3
Jens Tiefenbach, P. Moll, Meryl Nelson, Chun Hu, Lilia Baev, T. Kislinger, H. Krause (2010)
A Live Zebrafish-Based Screening System for Human Nuclear Receptor Ligand and Cofactor DiscoveryPLoS ONE, 5
Eun Hwang, J. Lee, Jiyeong Jeong, Joo Park, Young Yang, J. Lim, J. Kim, S. Baek, Keun-Il Kim (2009)
SUMOylation of RORalpha potentiates transcriptional activation function.Biochemical and biophysical research communications, 378 3
A. Ososki, E. Kennelly (2003)
Phytoestrogens: a review of the present state of researchPhytotherapy Research, 17
E. Raspé, H. Duez, A. Mansén, C. Fontaine, C. Fiévet, J. Fruchart, B. Vennström, B. Staels (2002)
Identification of Rev-erbalpha as a physiological repressor of apoC-III gene transcription.Journal of lipid research, 43 12
M. Hamblen, W. Zehring, C. Kyriacou, P. Reddy, Q. Yu, D. Wheeler, L. Zwiebel, R. Konopka, M. Rosbash, J. Hall (1986)
Germ-line transformation involving DNA from the period locus in Drosophila melanogaster: overlapping genomic fragments that restore circadian and ultradian rhythmicity to per0 and per- mutants.Journal of neurogenetics, 3 5
M. SchraderS, Michael Becker-AndrbO, Carsten CarlbergSfl (1994)
Thyroid Hormone Receptor Functions as Monomeric Ligand-induced Transcription Factor on Octameric Half-sites
J. Alessandri, P. Guesnet, S. Vancassel, P. Astorg, I. Denis, B. Langelier, S. Aïd, C. Poumès-Ballihaut, Gaëlle Champeil‐Potokar, M. Lavialle (2004)
Polyunsaturated fatty acids in the central nervous system: evolution of concepts and nutritional implications throughout life.Reproduction, nutrition, development, 44 6
U. Baschant, J. Tuckermann (2010)
The role of the glucocorticoid receptor in inflammation and immunityThe Journal of Steroid Biochemistry and Molecular Biology, 120
C. Carlberg, Sabine Seuter (2010)
Dynamics of nuclear receptor target gene regulationChromosoma, 119
R. Hasan, A. Schafer (2008)
Hemin Upregulates Egr-1 Expression in Vascular Smooth Muscle Cells via Reactive Oxygen Species ERK-1/2–Elk-1 and NF-&kgr;BCirculation Research, 102
S. Ryter, L. Otterbein (2004)
Carbon monoxide in biology and medicineBioEssays, 26
J. Woodson, J. Chory (2008)
Coordination of gene expression between organellar and nuclear genomesNature Reviews Genetics, 9
C. Stehlin-Gaon, Dominica Willmann, D. Zeyer, S. Sanglier, A. Dorsselaer, J. Renaud, D. Moras, R. Schüle (2003)
All-trans retinoic acid is a ligand for the orphan nuclear receptor RORβNature Structural Biology, 10
S. Raghuram, K. Stayrook, Pengxiang Huang*, P. Rogers, Amanda Nosie, D. Mcclure, L. Burris, S. Khorasanizadeh, T. Burris, F. Rastinejad (2007)
Identification of heme as the ligand for the orphan nuclear receptors REV-ERBα and REV-ERBβNature Structural &Molecular Biology, 14
K. Pardee, J. Reinking, H. Krause (2004)
Nuclear hormone receptors, metabolism, and aging: what goes around comes around. Transcription factors link lipid metabolism and aging-related processes.Science of aging knowledge environment : SAGE KE, 2004 47
Gabriel Markov, Mathilde Paris, Stéphanie Bertrand, V. Laudet (2008)
The evolution of the ligand/receptor couple: A long road from comparative endocrinology to comparative genomicsMolecular and Cellular Endocrinology, 293
J. Stender, Kyuri Kim, T. Charn, B. Komm, Ken Chang, W. Kraus, C. Benner, C. Glass, B. Katzenellenbogen (2010)
Genome-Wide Analysis of Estrogen Receptor α DNA Binding and Tethering Mechanisms Identifies Runx1 as a Novel Tethering Factor in Receptor-Mediated Transcriptional ActivationMolecular and Cellular Biology, 30
L. Rice (2010)
Hormone prevention strategies for breast, endometrial and ovarian cancers.Gynecologic oncology, 118 2
V. Chandra, Pengxiang Huang*, Y. Hamuro, S. Raghuram, Yongjun Wang, T. Burris, F. Rastinejad (2008)
Structure of the intact PPAR-γ–RXR-α nuclear receptor complex on DNANature, 456
I. Björkhem, V. Leoni, S. Meaney (2010)
Genetic connections between neurological disorders and cholesterol metabolismJournal of Lipid Research, 51
Hai-bing Peng, P. Libby, J. Liao (1995)
Induction and Stabilization of IκBα by Nitric Oxide Mediates Inhibition of NF-κB (*)The Journal of Biological Chemistry, 270
Jiying Sun, H. Hoshino, K. Takaku, O. Nakajima, A. Muto, Hiroshi Suzuki, S. Tashiro, Satoru Takahashi, S. Shibahara, J. Alam, M. Taketo, Masayuki Yamamoto, K. Igarashi (2002)
Hemoprotein Bach1 regulates enhancer availability of heme oxygenase‐1 geneThe EMBO Journal, 21
K. Kaasik, Cheng Lee (2004)
Reciprocal regulation of haem biosynthesis and the circadian clock in mammalsNature, 430
C. Thummel (2001)
Molecular mechanisms of developmental timing in C. elegans and Drosophila.Developmental cell, 1 4
R. Gampe, V. Montana, M. Lambert, Aaron Miller, R. Bledsoe, M. Milburn, S. Kliewer, T. Willson, H.E. Xu (2000)
Asymmetry in the PPARγ/RXRα Crystal Structure Reveals the Molecular Basis of Heterodimerization among Nuclear ReceptorsMolecular Cell, 5
D. Bechtold, J. Gibbs, A. Loudon (2010)
Circadian dysfunction in disease.Trends in pharmacological sciences, 31 5
G. Lukat-Rodgers, C. Correia, M. Botuyan, G. Mer, K. Rodgers (2010)
Heme-based sensing by the mammalian circadian protein CLOCK.Inorganic chemistry, 49 14
L. Yin, Nan Wu, M. Lazar (2010)
Nuclear receptor Rev-erbα: a heme receptor that coordinates circadian rhythm and metabolismNuclear Receptor Signaling, 8
Keith Baker, L. Shewchuk, T. Kozlova, M. Makishima, A. Hassell, B. Wisely, Justin Caravella, M. Lambert, J. Reinking, H. Krause, C. Thummel, T. Willson, D. Mangelsdorf (2003)
The Drosophila Orphan Nuclear Receptor DHR38 Mediates an Atypical Ecdysteroid Signaling PathwayCell, 113
D. Schmidt, D. Mangelsdorf (2008)
Nuclear receptors of the enteric tract: guarding the frontier.Nutrition reviews, 66 10 Suppl 2
U. Schibler, F. Naef (2005)
Cellular oscillators: rhythmic gene expression and metabolism.Current opinion in cell biology, 17 2
T. Willson, John Moore (2002)
Genomics versus orphan nuclear receptors--a half-time report.Molecular endocrinology, 16 6
H. Schäcke, M. Berger, H. Rehwinkel, K. Asadullah (2007)
Selective glucocorticoid receptor agonists (SEGRAs): Novel ligands with an improved therapeutic indexMolecular and Cellular Endocrinology, 275
L. Dominguez, Rosalinda Scalisi, M. Barbagallo (2010)
Therapeutic options in osteoporosis.Acta bio-medica : Atenei Parmensis, 81 Suppl 1
A. Chawla, J. Repa, R. Evans, D. Mangelsdorf (2001)
Nuclear receptors and lipid physiology: opening the X-files.Science, 294 5548
V. Laudet (1997)
Evolution of the nuclear receptor superfamily: early diversification from an ancestral orphan receptor.Journal of molecular endocrinology, 19 3
E. Dioum, J. Rutter, J. Tuckerman, G. Gonzalez, M. Gilles‐Gonzalez, S. McKnight (2002)
NPAS2: A Gas-Responsive Transcription FactorScience, 298
V. Giguère, E. Ong, Prudimar Segui, R. Evans (1987)
Identification of a receptor for the morphogen retinoic acidNature, 330
D. Bain, A. Heneghan, K. Connaghan-Jones, Michael Miura (2007)
Nuclear receptor structure: implications for function.Annual review of physiology, 69
S. Teague (2003)
Implications of protein flexibility for drug discoveryNature Reviews Drug Discovery, 2
I. Lascombe, D. Beffa, U. Rüegg, J. Tarradellas, W. Wahli (2000)
Estrogenic activity assessment of environmental chemicals using in vitro assays: identification of two new estrogenic compounds.Environmental Health Perspectives, 108
Gilles Tremblay, T. Kunath, Denis Bergeron, Line Lapointe, C. Champigny, J. Bader, Janet Rossant, Vincent Giguère (2001)
Diethylstilbestrol regulates trophoblast stem cell differentiation as a ligand of orphan nuclear receptor ERR beta.Genes & development, 15 7
J. Kallen, J. Schlaeppi, F. Bitsch, S. Geisse, M. Geiser, Isabelle Delhon, B. Fournier (2002)
X-Ray Structure of the hRORα LBD at 1.63 ÅStructure, 10
D. Mangelsdorf, K. Umesono, S. Kliewer, U. Borgmeyer, E. Ong, R. Evans (1991)
A direct repeat in the cellular retinol-binding protein type II gene confers differential regulation by RXR and RARCell, 66
Jin-Qiang Chen, T. Brown, J. Russo (2009)
Regulation of energy metabolism pathways by estrogens and estrogenic chemicals and potential implications in obesity associated with increased exposure to endocrine disruptors.Biochimica et biophysica acta, 1793 7
M. Petkovich, N. Brand, A. Krust, P. Chambon (1987)
A human retinoic acid receptor which belongs to the family of nuclear receptorsNature, 330
S. Dhe-Paganon, K. Duda, M. Iwamoto, Y. Chi, S. Shoelson (2002)
Crystal Structure of the HNF4α Ligand Binding Domain in Complex with Endogenous Fatty Acid Ligand*The Journal of Biological Chemistry, 277
F. Grün, B. Blumberg (2007)
Perturbed nuclear receptor signaling by environmental obesogens as emerging factors in the obesity crisisReviews in Endocrine and Metabolic Disorders, 8
J. Orans, Denise Teotico, M. Redinbo (2005)
The nuclear xenobiotic receptor pregnane X receptor: recent insights and new challenges.Molecular endocrinology, 19 12
Gina Clayton, S. Peak-Chew, Ronald Evans, John Schwabe (2001)
The structure of the ultraspiracle ligand-binding domain reveals a nuclear receptor locked in an inactive conformation.Proceedings of the National Academy of Sciences of the United States of America, 98 4
E. Jensen, V. Jordan (2003)
The estrogen receptor: a model for molecular medicine.Clinical cancer research : an official journal of the American Association for Cancer Research, 9 6
J. Truman, L. Riddiford, L. Safranek (1974)
Temporal patterns of response to ecdysone and juvenile hormone in the epidermis of the tobacco hornworm, Manduca sextaDevelopmental Biology, 39
Yangsik Jeong, D. Mangelsdorf (2009)
Nuclear receptor regulation of stemness and stem cell differentiationExperimental & Molecular Medicine, 41
Chunyan Zhao, Hui Gao, Yawen Liu, Z. Papoutsi, Sadaf Jaffrey, J. Gustafsson, K. Dahlman-Wright (2010)
Genome-wide mapping of estrogen receptor-beta-binding regions reveals extensive cross-talk with transcription factor activator protein-1.Cancer research, 70 12
Frontiers in Aging Neuroscience Aging Neuroscience Review Article Mechanism of Action
M. Rubio, P. Agostino, G. Ferreyra, D. Golombek (2003)
Circadian heme oxygenase actitivy in the hamster suprachiasmatic nucleiNeuroscience Letters, 353
Elena Doukhanina, N. Apuya, H. Yoo, Chuan-yin Wu, Patricia Davidow, S. Krueger, R. Flavell, R. Hamilton, S. Bobzin (2007)
Expression of Human Nuclear Receptors in Plants for the Discovery of Plant-Derived LigandsJournal of Biomolecular Screening, 12
A. Wärnmark, E. Treuter, A. Wright, J. Gustafsson (2003)
Activation functions 1 and 2 of nuclear receptors: molecular strategies for transcriptional activation.Molecular endocrinology, 17 10
Micah Gearhart, S. Holmbeck, Ronald Evans, H. Dyson, Peter Wright (2003)
Monomeric complex of human orphan estrogen related receptor-2 with DNA: a pseudo-dimer interface mediates extended half-site recognition.Journal of molecular biology, 327 4
J. Lumeng, D. Somashekar, Danielle Appugliese, N. Kaciroti, Robert Corwyn, R. Bradley (2007)
Shorter Sleep Duration Is Associated With Increased Risk for Being Overweight at Ages 9 to 12 YearsPediatrics, 120
E. Rosny, A. Groot, C. Jullian-Binard, F. Borel, Cristian Suarez, L. Pape, J. Fontecilla-Camps, H. Jouve (2008)
DHR51, the Drosophila melanogaster homologue of the human photoreceptor cell-specific nuclear receptor, is a thiolate heme-binding protein.Biochemistry, 47 50
J. Reinking, Mandy Lam, K. Pardee, Heidi Sampson, Suya Liu, Ping Yang, Shawn Williams, Wendy White, G. Lajoie, A. Edwards, H. Krause (2005)
The Drosophila Nuclear Receptor E75 Contains Heme and Is Gas ResponsiveCell, 122
A. Tsiftsoglou, A. Tsamadou, L. Papadopoulou (2006)
Heme as key regulator of major mammalian cellular functions: molecular, cellular, and pharmacological aspects.Pharmacology & therapeutics, 111 2
D. Kamen, V. Tangpricha (2010)
Vitamin D and molecular actions on the immune system: modulation of innate and autoimmunityJournal of Molecular Medicine, 88
F. Guillaumond, H. Dardente, V. Giguère, N. Cermakian (2005)
Differential Control of Bmal1 Circadian Transcription by REV-ERB and ROR Nuclear ReceptorsJournal of Biological Rhythms, 20
M. Niino, M. Hirotani, T. Fukazawa, S. Kikuchi, H. Sasaki (2009)
Estrogens as potential therapeutic agents in multiple sclerosis.Central nervous system agents in medicinal chemistry, 9 2
A. Foryst-Ludwig, U. Kintscher (2010)
Metabolic impact of estrogen signalling through ERalpha and ERbetaThe Journal of Steroid Biochemistry and Molecular Biology, 122
A. Harel-Bellan, Valentina Guasconi, L. Fritsch, Redha Sekhri, H. Lehrmann, S. Ait-Si-Ali (2001)
Histone acetylation and diseaseCellular and Molecular Life Sciences CMLS, 58
H. Coste, Joan Rodrı́guez (2002)
Orphan Nuclear Hormone Receptor Rev-erbα Regulates the Human Apolipoprotein CIII Promoter*The Journal of Biological Chemistry, 277
O. Froy (2007)
The relationship between nutrition and circadian rhythms in mammalsFrontiers in Neuroendocrinology, 28
Yoon‐Kwang Lee, Yun-Hee Choi, Steven Chua, Y. Park, D. Moore (2006)
Phosphorylation of the Hinge Domain of the Nuclear Hormone Receptor LRH-1 Stimulates Transactivation*Journal of Biological Chemistry, 281
W. Bourguet, M. Ruff, P. Chambon, H. Gronemeyer, D. Moras (1995)
Crystal structure of the ligand-binding domain of the human nuclear receptor RXR-αNature, 375
K. Pardee, Xiaohui Xu, J. Reinking, A. Schuetz, A. Dong, Suya Liu, Rong-guang Zhang, Jens Tiefenbach, G. Lajoie, A. Plotnikov, A. Botchkarev, H. Krause, A. Edwards (2009)
The Structural Basis of Gas-Responsive Transcription by the Human Nuclear Hormone Receptor REV-ERBβPLoS Biology, 7
E. Masoro (2000)
Caloric restriction and aging: an updateExperimental Gerontology, 35
V. Giguère (1999)
Orphan nuclear receptors: from gene to function.Endocrine reviews, 20 5
J. Vaya, H. Schipper (2007)
Oxysterols, cholesterol homeostasis, and Alzheimer diseaseJournal of Neurochemistry, 102
X. Yang, K. Lamia, Ronald Evans (2007)
Nuclear receptors, metabolism, and the circadian clock.Cold Spring Harbor symposia on quantitative biology, 72
W. Wahli (2008)
A gut feeling of the PXR, PPAR and NF‐κB connectionJournal of Internal Medicine, 263
Guang Chen, Li-dong Huang, Yi‐Ming Jiang, H. Manji (2000)
The Mood‐Stabilizing Agent Valproate Inhibits the Activity of Glycogen Synthase Kinase‐3Journal of Neurochemistry, 72
Ya-Fen Wang, H. Chao, Chia-Hsin Wu, Chu-Han Tseng, Y. Kuo, T. Tsou (2010)
A recombinant peroxisome proliferator response element-driven luciferase assay for evaluation of potential environmental obesogensBiotechnology Letters, 32
B. Shearer, John Moore, Aaron Miller, T. Willson, Shawn Williams (2002)
Hepatocyte nuclear factor 4 is a transcription factor that constitutively binds fatty acids.Structure, 10 9
S. Conzen (2008)
Minireview: nuclear receptors and breast cancer.Molecular endocrinology, 22 10
V. Longo, C. Finch (2003)
Evolutionary Medicine: From Dwarf Model Systems to Healthy Centenarians?Science, 299
A. Kleiman, J. Tuckermann (2007)
Glucocorticoid receptor action in beneficial and side effects of steroid therapy: Lessons from conditional knockout miceMolecular and Cellular Endocrinology, 275
A. Jetten (2009)
Retinoid-related orphan receptors (RORs): critical roles in development, immunity, circadian rhythm, and cellular metabolismNuclear Receptor Signaling, 7
L. Dinan, R. Lafont (2006)
Effects and applications of arthropod steroid hormones (ecdysteroids) in mammals.The Journal of endocrinology, 191 1
Y. Shang, Myles Brown (2002)
Molecular Determinants for the Tissue Specificity of SERMsScience, 295
C. McClung (2007)
Circadian genes, rhythms and the biology of mood disorders.Pharmacology & therapeutics, 114 2
I. Billas, L. Moulinier, N. Rochel, D. Moras (2001)
Crystal Structure of the Ligand-binding Domain of the Ultraspiracle Protein USP, the Ortholog of Retinoid X Receptors in Insects*The Journal of Biological Chemistry, 276
I. McEwan (2004)
Sex, drugs and gene expression: signalling by members of the nuclear receptor superfamily.Essays in biochemistry, 40
Keith Baker, J. Warren, C. Thummel, Lawrence Gilbert, David Mangelsdorf (2000)
Transcriptional activation of the Drosophila ecdysone receptor by insect and plant ecdysteroids.Insect biochemistry and molecular biology, 30 11
V. Perissi, M. Rosenfeld (2005)
Controlling nuclear receptors: the circular logic of cofactor cyclesNature Reviews Molecular Cell Biology, 6
Zhulun Wang, G. Benoit, Jinsong Liu, Srividya Prasad, P. Aarnisalo, Xiaohong Liu, Haoda Xu, N. Walker, T. Perlmann (2003)
Structure and function of Nurr1 identifies a class of ligand-independent nuclear receptorsNature, 423
R. Chaturvedi, M. Beal (2008)
PPAR: a therapeutic target in Parkinson’s diseaseJournal of Neurochemistry, 106
[One of the largest groups of metazoan transcription factors (TFs), the Nuclear Receptor superfamily, regulates genes required for virtually all aspects of development, reproduction and metabolism. Together, these master regulators can be thought of as a fundamental operating system for metazoan life. Their most distinguishing feature is a structurally conserved domain that acts as a switch, powered by the presence of small diffusible ligands. This ligand-responsive regulation has allowed the Nuclear Receptors to help their hosts adapt to a wide variety of physiological niches and roles, making them one of the most evolutionarily successful TF families. Originally discovered as receptors for steroid hormones, the Nuclear Receptor field has grown to encompass much more than traditional endocrinology. For example, recent work has highlighted the role of Nuclear Receptors as major regulators of metabolism and biological clocks. By monitoring endogenous metabolites and absorbed xenobiotics, these receptors also coordinate rapid, system-wide responses to changing metabolic and environmental states. While many new Nuclear Receptor ligands have been discovered in the past couple of decades, approximately half of the 48 human receptors are still orphans, with a significantly higher percentage of orphans in other organisms. The discovery of new ligands has led to the elucidation of new regulatory mechanisms, target genes, pathways and functions. This review will highlight both the common as well as newly emerging traits and functions that characterize this particularly unique and important TF family.]
Published: Apr 14, 2011
Keywords: Nuclear receptor; Ligand; Metabolism; Hormone; Endocrine
Read and print from thousands of top scholarly journals.
Already have an account? Log in
Bookmark this article. You can see your Bookmarks on your DeepDyve Library.
To save an article, log in first, or sign up for a DeepDyve account if you don’t already have one.
Copy and paste the desired citation format or use the link below to download a file formatted for EndNote
Access the full text.
Sign up today, get DeepDyve free for 14 days.
All DeepDyve websites use cookies to improve your online experience. They were placed on your computer when you launched this website. You can change your cookie settings through your browser.