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A Handbook of Transcription FactorsTranscription Factor Binding Sites and Other Features in Human and Drosophila Proximal Promoters

A Handbook of Transcription Factors: Transcription Factor Binding Sites and Other Features in... [Eukaryotic promoters determine transcription start sites (TSSs), and are often enriched for transcription factor binding sites (TFBSs), which presumably play a major role in determining the location and activity of the TSS. In mammalian systems, proximal promoters are enriched for the CpG dinucleotide. The TFBSs that are enriched in proximal promoters (–200 bps to the TSS) are CCAAT, ETS, NRF1, SP1, E-Box, CRE, BoxA, and TATA. Only TATA occurs in a DNA strand dependent manner. In Drosophila, proximal promoters are AT rich and many putative TFBSs are enriched in proximal promoters. These sequences are different from those that occur in human promoters, except for TATA and E-Box, and many occur on a single strand of DNA giving directionality to the promoter. Thus, fundamental differences have arisen as promoters evolved in metazoans.] http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png

A Handbook of Transcription FactorsTranscription Factor Binding Sites and Other Features in Human and Drosophila Proximal Promoters

Part of the Subcellular Biochemistry Book Series (volume 52)
Editors: Hughes, Timothy R.
Vinson, Charles; Chatterjee, Raghunath; Fitzgerald, Peter
A Handbook of Transcription Factors — Apr 14, 2011
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17 pages

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Publisher
Springer Netherlands
Copyright
© Springer Science+Business Media B.V. 2011
ISBN
978-90-481-9068-3
Pages
205 –222
DOI
10.1007/978-90-481-9069-0_10
Publisher site
See Chapter on Publisher Site

Abstract

[Eukaryotic promoters determine transcription start sites (TSSs), and are often enriched for transcription factor binding sites (TFBSs), which presumably play a major role in determining the location and activity of the TSS. In mammalian systems, proximal promoters are enriched for the CpG dinucleotide. The TFBSs that are enriched in proximal promoters (–200 bps to the TSS) are CCAAT, ETS, NRF1, SP1, E-Box, CRE, BoxA, and TATA. Only TATA occurs in a DNA strand dependent manner. In Drosophila, proximal promoters are AT rich and many putative TFBSs are enriched in proximal promoters. These sequences are different from those that occur in human promoters, except for TATA and E-Box, and many occur on a single strand of DNA giving directionality to the promoter. Thus, fundamental differences have arisen as promoters evolved in metazoans.]

Published: Apr 14, 2011

Keywords: Transcriptional Start Site; Proximal Promoter; Palindromic Sequence; Human Promoter; cAMP Responsive Element

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