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A Modern Approach to Biofilm-Related Orthopaedic Implant InfectionsMechanisms of Bacterial Colonization of Implants and Host Response

A Modern Approach to Biofilm-Related Orthopaedic Implant Infections: Mechanisms of Bacterial... [The review focuses on the current knowledge and the most pertinent hypotheses regarding the local host immune response as the key factor for the pathogenesis of implant-associated infections. Although bacterial biofilms have long been recognized as causative agents, the link between the infection and the devastating inflammatory response, particularly the localized tissue destruction and bone degradation is less well understood. Understanding these consequences of infection, however, is of utmost importance, because suppressing inflammation and preventing bone destruction could be a novel, alternative therapeutic option in cases when eradicating the infections fails.] http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png

A Modern Approach to Biofilm-Related Orthopaedic Implant InfectionsMechanisms of Bacterial Colonization of Implants and Host Response

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References (95)

Publisher
Springer International Publishing
Copyright
© Springer International Publishing AG 2017
ISBN
978-3-319-52273-9
Pages
15 –27
DOI
10.1007/5584_2016_173
Publisher site
See Chapter on Publisher Site

Abstract

[The review focuses on the current knowledge and the most pertinent hypotheses regarding the local host immune response as the key factor for the pathogenesis of implant-associated infections. Although bacterial biofilms have long been recognized as causative agents, the link between the infection and the devastating inflammatory response, particularly the localized tissue destruction and bone degradation is less well understood. Understanding these consequences of infection, however, is of utmost importance, because suppressing inflammation and preventing bone destruction could be a novel, alternative therapeutic option in cases when eradicating the infections fails.]

Published: Nov 5, 2016

Keywords: Implant infection; Bacterial biofilm; Immune response; Neutrophils; Osteolysis

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