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A Novel Molecular Imprinted Polymers-Based Lateral Flow Strip for Sensitive Detection of Thiodiglycol

A Novel Molecular Imprinted Polymers-Based Lateral Flow Strip for Sensitive Detection of... Traditional detection of thiodiglycol (TDG), a metabolic marker for sulfur mustard poisoning, requires not only professional operators, but also expensive reagents and large instruments. Herein, we developed a novel molecular imprinted polymers (MIPs)-based lateral flow assay (LFA) strategy for the quick, sensitive, and selective detection of TDG. Gold nanoparticles (AuNPs), MIPs, and metallothioneins (MTs) were respectively loaded on the conjugate pad, test line (T line) and control line (C line). After adding TDG, AuNPs on the conjugate pad reacted with TDG through the Au–S bond first. Then, under the action of capillary force, the conjugates of TDG and AuNPs were trapped by the MIPs as they traveled to the T line, and the residual AuNPs bound with the MTs on the C line, exhibiting two obvious red bands on T line and C line, respectively. In contrast, a single red band could be observed on C line without TDG. This method exhibited a wide linear range from 10.0 pg/mL to 10,000.0 ng/mL and its limit of detection (LOD) was as low as 0.41 pg/mL. This method was successfully utilized to detect TDG in human urine, presenting significant potential in the point-of-care testing of TDG in clinical samples of the sulfur mustard poisoning patients. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Journal of Analysis and Testing Springer Journals

A Novel Molecular Imprinted Polymers-Based Lateral Flow Strip for Sensitive Detection of Thiodiglycol

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Publisher
Springer Journals
Copyright
Copyright © The Nonferrous Metals Society of China 2023. Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.
ISSN
2096-241X
eISSN
2509-4696
DOI
10.1007/s41664-023-00250-6
Publisher site
See Article on Publisher Site

Abstract

Traditional detection of thiodiglycol (TDG), a metabolic marker for sulfur mustard poisoning, requires not only professional operators, but also expensive reagents and large instruments. Herein, we developed a novel molecular imprinted polymers (MIPs)-based lateral flow assay (LFA) strategy for the quick, sensitive, and selective detection of TDG. Gold nanoparticles (AuNPs), MIPs, and metallothioneins (MTs) were respectively loaded on the conjugate pad, test line (T line) and control line (C line). After adding TDG, AuNPs on the conjugate pad reacted with TDG through the Au–S bond first. Then, under the action of capillary force, the conjugates of TDG and AuNPs were trapped by the MIPs as they traveled to the T line, and the residual AuNPs bound with the MTs on the C line, exhibiting two obvious red bands on T line and C line, respectively. In contrast, a single red band could be observed on C line without TDG. This method exhibited a wide linear range from 10.0 pg/mL to 10,000.0 ng/mL and its limit of detection (LOD) was as low as 0.41 pg/mL. This method was successfully utilized to detect TDG in human urine, presenting significant potential in the point-of-care testing of TDG in clinical samples of the sulfur mustard poisoning patients.

Journal

Journal of Analysis and Testing – Springer Journals

Published: Jun 1, 2023

Keywords: Molecular imprinted polymers; Lateral flow assay; Thiodiglycol

References

  • Porphyrinic silver cluster assembled material for simultaneous capture and photocatalysis of mustard-gas simulant
    Cao, M; Pang, R; Wang, QY; Han, Z; Wang, ZY; Dong, XY; Li, SF; Zang, SQ; Thomas, CWM
  • A wearable origami-like paper-based electrochemical biosensor for sulfur mustard detection
    Colozza, N; Kehe, K; Dionisi, G; Popp, T; Tsoutsoulopoulos, A; Steinritz, D; Moscone, D; Arduini, F
  • Selective photodetoxification of a sulfur mustard simulant using plasmonic aluminum nanoparticles
    Lou, MH; Aaron, B; Henry, OE; Naomi, JH
  • Post-oxidation of a fully conjugated benzotrithiophene-based COF for photocatalytic detoxification of a sulfur mustard simulant
    Li, S; Lu, D; Li, L; Anwang, D; Li, JN; Meng, XJ; Wang, B; Li, PF
  • Visualization of sulfur mustard in living cells and whole animals with a selective and sensitive turn-on fluorescent probe
    Meng, WQ; Zhang, H; Xiao, L; Chen, XT; Sun, MX; Xu, QQ; Cao, YB; Xiao, K; Li, ZJ
  • A selective turn-on fluorescent sensor for sulfur mustard simulants
    Kumar, V; Anslyn, EV
  • Ultrafast sulfur mustard simulant gas fluorescent chemosensors based on triazole AIEE material with high selectivity and sensitivity at room temperature
    Zheng, P; Cao, WJ; Zhang, YM; Li, F; Zhang, M
  • Fe-doped MoS2 nanozyme for antibacterial activity and detoxification of mustard gas simulant
    Ali, SR; De, M
  • Detection of chemical warfare agents with a miniaturized high-performance drift tube ion mobility spectrometer using high-energetic photons for ionization
    Ahrens, A; Allers, M; Bock, H; Hitzemann, Z; Ficks, A; Zimmermann, S
  • Detoxification of the toxic sulfur mustard simulant by a supramolecular antidote in vitro and in vivo
    Zhou, SY; Li, WZ; Zhao, Q; Dong, HQ; Wang, WQ; Lu, FH; Zhao, JH; Liu, SS; Chen, H; Wang, L; Liu, W; Zhang, MC; Chen, SG
  • Construction of a degradation-free DNA conjugated nanoprobe and its application in rapid field screening for sulfur mustard
    Sun, JF; Li, CZ; Shan, WC; Wei, YH; Liu, R; Li, H; Cao, D; Guo, QZ; Zhao, HC; Liu, RQ; Shao, B
  • Route determination of sulfur mustard using nontargeted chemical attribution signature screening
    Holmgren, KH; Mörén, L; Ahlinder, L; Larsson, A; Wiktelius, D; Norlin, R; Åstot, C
  • Determination of mustard gas hydrolysis products thiodiglycol and thiodiglycol sulfoxide by gas chromatography-tandem mass spectrometry after trifluoroacetylation
    Popiel, S; Nawala, J; Dziedzic, D; Soderstrom, M; Vanninen, P
  • Challenges in fluorescence detection of chemical warfare agent vapors using solid-state films
    Fan, SQ; Zhang, GR; Dennison, GH; FitzGerald, N; Burn, PL; Gentle, IR; Shaw, PE
  • Chemodosimeter for selective and sensitive chromogenic and fluorogenic detection of mustard gas for real time analysis
    Kumar, V; Rana, H; Raviraju, G; Gupta, AK
  • Multiclonal plastic antibodies for selective aflatoxin extraction from food samples
    Bayram, E; Yilmaz, E; Uzun, L; Say, R; Denizli, A
  • Lateral flow assay of methicillin-resistant Staphylococcus aureus using bacteriophage cellular wall-binding domain as recognition agent
    Yang, HL; Wang, YR; Liu, SY; Ouyang, H; Lu, SG; Li, HT; Fu, ZF
  • Rapid, ultrasensitive, and highly specific diagnosis of COVID-19 by CRISPR-based detection
    Zhu, X; Wang, XX; Li, SJ; Luo, WK; Zhang, XP; Wang, CZ; Chen, Q; Yu, SY; Tai, J; Wang, Y
  • Using a glucose meter to quantitatively detect disease biomarkers through a universal nanozyme integrated lateral fluidic sensing platform
    Zhu, XN; Sarwar, M; Zhu, JJ; Zhang, CX; Kaushik, A; Li, CZ
  • Competitive horseradish peroxidase-linked aptamer assay for sensitive detection of Aflatoxin B1
    Sun, LL; Zhao, Q
  • Lateral flow aptasensor for small molecule targets exploiting adsorption and desorption interactions on gold nanoparticles
    Alsager, OA; Kumar, S; Hodgkiss, JM
  • Preparation of a molecularly imprinted test strip for point-of-care detection of thiodiglycol, a sulfur mustard poisoning metabolic marker
    Ye, QC; Men, C; Tian, LL; Liu, YX; Zhan, L; Li, YF; Huang, CZ; Zhen, SJ
  • Frontiers in biomedical engineering
    Gao, XH
  • A novel microfluidic paper-based colorimetric sensor based on molecularly imprinted polymer membranes for highly selective and sensitive detection of bisphenol A
    Kong, QK; Wang, YH; Zhang, LN; Ge, SG; Yu, JH
  • A signal on-off ratiometric electrochemical sensor coupled with a molecular imprinted polymer for selective and stable determination of imidacloprid
    Zhang, W; Liu, C; Han, KG; Wei, XO; Xu, YW; Zou, XB; Zhang, H; Chen, ZY
  • A highly sensitive sensor based on a computer-designed magnetic molecularly imprinted membrane for the determination of acetaminophen
    Su, CL; Li, ZY; Zhang, D; Wang, ZM; Zhou, X; Liao, LF; Xiao, XL
  • A novel capacitive sensor based on molecularly imprinted nanoparticles as recognition elements
    Canfarotta, F; Czulak, J; Guerreiro, A; Cruz, AG; Piletsky, S; Bergdahl, GE; Hedstrom, M; Mattiasson, B
  • DNA tetrahedra-cross-linked hydrogel functionalized paper for onsite analysis of DNA methyltransferase activity using a personal glucose meter
    Gao, X; Li, XY; Sun, XZ; Zhang, JY; Zhao, YC; Liu, XJ; Li, F
  • Biomimetic electrochemical sensor for the highly selective detection of azithromycin in biological samples
    Stoian, I-A; Iacob, B-C; Dudaș, C-L; Barbu-Tudoran, L; Bogdan, D; Marian, IO; Bodoki, E; Oprean, R
  • Direct and sensitive determination of trypsin in human urine using a water-soluble signaling fluorescent molecularly imprinted polymer nanoprobe
    Xu, JJ; Prost, E; Haupt, K; Bui, BTS
  • Synthesis and application of molecularly imprinted polymers for trypsin piezoelectric sensors
    Karaseva, NA; Pluhar, B; Beliaeva, EA; Ermolaeva, TN; Mizaikoff, B
  • Room temperature phosphorescent determination of aflatoxins in fish feed based on molecularly imprinted polymer - Mn-doped ZnS quantum dots
    Jayasinghe, GDTM; Domínguez-González, R; Bermejo-Barrera, P; Moreda-Piñeiro, A
  • Development of fluorescent lateral flow test strips based on an electrospun molecularly imprinted membrane for detection of triazophos residues in tap water
    He, YH; Hong, SH; Wang, M; Wang, J; Aty, AMAE; Wang, J; Hacimuftuoglu, A; Khan, M; She, YX
  • Development of a time-resolved fluorescence microsphere Eu lateral flow test strip based on a molecularly imprinted electrospun nanofiber membrane for determination of fenvalerate in vegetables
    Zhang, L; Zheng, YL; Shao, H; Xiao, M; Sun, JC; Jin, MJ; Jin, F; Wang, J; Aty, AMAE; She, YX
  • Copper deposition-induced efficient signal amplification for ultrasensitive lateral flow immunoassay
    Tian, ML; Lei, LL; Xie, WY; Yang, QM; Li, CM; Liu, YS
  • Rapid analysis of chemical warfare agents by metal needle-enhanced low-temperature plasma mass spectrometry
    Zhang, L; Zhao, X; Zhao, YB; Xu, FJ; Kong, JL; Hu, ZA; Ma, MY; Zhang, SC; Zhang, XR
  • Simultaneous quantification of four metabolites of sulfur mustard in urine samples by ultra-high performance liquid chromatography-tandem mass spectrometry after solid phase extraction
    Liu, CC; Liu, SL; Xi, HL; Yu, HL; Zhou, SK; Huang, GL; Liang, LH; Liu, JQ
  • Rapid detection of sulfur mustard hydrolysis products based on microextraction by packed sorbent combined with nano-electrospray ionization mass spectrometry
    Li, BQ; Wei, JN; Kong, JL; Yang, L; Li, C
  • Gas chromatography-tandem mass spectrometry verification of sulfur mustard exposure in humans through the conversion of protein adducts to free sulfur mustard
    Young, SA; Capacio, BR