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A Pattern Approach to Lymph Node DiagnosisImmunohistology and Other Diagnostic Techniques

A Pattern Approach to Lymph Node Diagnosis: Immunohistology and Other Diagnostic Techniques [While morphologic examination of H&E-stained sections remains the cornerstone of lymph node diagnosis, a wide variety of ancillary investigations have served to better define the malignant lymphomas and leukemias. Importantly, they have contributed to a conceptual understanding of the lymphomas, particularly those of B cell lineage. Among the more common techniques that are useful in diagnosis are immunohistology, flow cytometry, cytogenetics, and molecular analysis, with histochemistry, electron microscopy, and bacterial and viral cultures providing useful diagnostic information in more specific situations. Gene expression profiling and proteomics are still research tools but have enhanced our knowledge and facilitated the introduction of new immunohistochemical markers.] http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png

A Pattern Approach to Lymph Node DiagnosisImmunohistology and Other Diagnostic Techniques

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Publisher
Springer New York
Copyright
© Springer Science+Business Media, LLC 2011
ISBN
978-1-4419-7175-3
Pages
23 –61
DOI
10.1007/978-1-4419-7176-0_3
Publisher site
See Chapter on Publisher Site

Abstract

[While morphologic examination of H&E-stained sections remains the cornerstone of lymph node diagnosis, a wide variety of ancillary investigations have served to better define the malignant lymphomas and leukemias. Importantly, they have contributed to a conceptual understanding of the lymphomas, particularly those of B cell lineage. Among the more common techniques that are useful in diagnosis are immunohistology, flow cytometry, cytogenetics, and molecular analysis, with histochemistry, electron microscopy, and bacterial and viral cultures providing useful diagnostic information in more specific situations. Gene expression profiling and proteomics are still research tools but have enhanced our knowledge and facilitated the introduction of new immunohistochemical markers.]

Published: Sep 3, 2010

Keywords: Immunoglobulins; B cell markers; T cell markers; NK/T cell markers; precursor B cell markers; precursor T cell markers; monocyte/macrophage markers; Langerhans cell markers; FDC markers; DRC markers; Reed–Sternberg/Hodgkin cell markers; myeloid markers; mast cell markers; histochemistry; flow cytometry; molecular analysis; gene expression profiling

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