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A Quick Guide to Pediatric RetinaAnimal Models of Retinopathy of Prematurity

A Quick Guide to Pediatric Retina: Animal Models of Retinopathy of Prematurity [Retinopathy of prematurity (ROP) is a leading cause of blindness in preterm infants. It is a biphasic disease characterized by an initial phase of arrested vascular growth caused by hyperoxia exposure and loss of maternal–fetal interaction, followed by a second phase of hypoxia-induced neovascularization, which may lead to retinal detachment and vision loss. Animal models of ROP are crucial for studying the cellular and molecular mechanisms underlying ROP pathogenesis and for the development of potential therapeutics. Early animal models of oxygen-induced ROP were developed in the 1950s in multiple species including feline, canine, and murine, after the recognition of supplemental oxygen use as a risk factor. Refined mouse and rat models of oxygen-induced retinopathy were modernized in the 1990s with standardized oxygen protocols and improved methods for assessing retinopathy severity. More recently, murine models of hyperglycemia-associated neonatal retinopathy were developed to mimic neonatal hyperglycemia, a newly identified ROP risk factor. This chapter summarizes the basic concepts, advantages, and limitations of animal models of ROP, with a focus on the most widely used mouse model of oxygen-induced retinopathy.] http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png

A Quick Guide to Pediatric RetinaAnimal Models of Retinopathy of Prematurity

Editors: Wu, Wei-Chi; Lam, Wai-Ching
Liu, Chi-Hsiu; Chen, Jing
A Quick Guide to Pediatric Retina — Jan 19, 2021
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References (85)

Publisher
Springer Singapore
Copyright
© Springer Nature Singapore Pte Ltd. 2021
ISBN
978-981-15-6551-9
Pages
11 –19
DOI
10.1007/978-981-15-6552-6_2
Publisher site
See Chapter on Publisher Site

Abstract

[Retinopathy of prematurity (ROP) is a leading cause of blindness in preterm infants. It is a biphasic disease characterized by an initial phase of arrested vascular growth caused by hyperoxia exposure and loss of maternal–fetal interaction, followed by a second phase of hypoxia-induced neovascularization, which may lead to retinal detachment and vision loss. Animal models of ROP are crucial for studying the cellular and molecular mechanisms underlying ROP pathogenesis and for the development of potential therapeutics. Early animal models of oxygen-induced ROP were developed in the 1950s in multiple species including feline, canine, and murine, after the recognition of supplemental oxygen use as a risk factor. Refined mouse and rat models of oxygen-induced retinopathy were modernized in the 1990s with standardized oxygen protocols and improved methods for assessing retinopathy severity. More recently, murine models of hyperglycemia-associated neonatal retinopathy were developed to mimic neonatal hyperglycemia, a newly identified ROP risk factor. This chapter summarizes the basic concepts, advantages, and limitations of animal models of ROP, with a focus on the most widely used mouse model of oxygen-induced retinopathy.]

Published: Jan 19, 2021

Keywords: Retinopathy of prematurity; Animal models; Oxygen-induced retinopathy; Vaso-obliteration; Neovascularization

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