Access the full text.
Sign up today, get DeepDyve free for 14 days.
W. Dailey, Wojciech Gryc, P. Garg, K. Drenser (2015)
Frizzled-4 Variations Associated with Retinopathy and Intrauterine Growth Retardation: A Potential Marker for Prematurity and Retinopathy.Ophthalmology, 122 9
M. Hartnett, M. DeAngelis (2012)
The Role of Reactive Oxygen Species and Oxidative Signaling in Retinopathy of Prematurity
P. Manzoni, Roberta Guardione, P. Bonetti, C. Priolo, A. Maestri, C. Mansoldo, M. Mostert, G. Anselmetti, Daniela Sardei, M. Bellettato, P. Biban, D. Farina (2012)
Lutein and Zeaxanthin Supplementation in Preterm Very Low-Birth-Weight Neonates in Neonatal Intensive Care Units: A Multicenter Randomized Controlled TrialAmerican Journal of Perinatology, 30
W. Carlo, N. Finer, M. Walsh, W. Rich, M. Gantz, A. Laptook, B. Yoder, R. Faix, A. Das, W. Poole, K. Schibler, N. Newman, N. Ambalavanan, I. Frantz, A. Piazza, P. Sánchez, Brenda Morris, N. Laroia, D. Phelps, B. Poindexter, C. Cotten, K. Meurs, S. Duara, V. Narendran, B. Sood, T. O'Shea, E. Bell, R. Ehrenkranz, K. Watterberg, R. Higgins (2010)
Target ranges of oxygen saturation in extremely preterm infants.The New England journal of medicine, 362 21
No Authors (1984)
10.1001/archopht.1984.01040030908011Arch Ophthalmol, 102
A. Fielder (2003)
Preliminary results of treatment of eyes with high-risk prethreshold retinopathy of prematurity in the early treatment for retinopathy of prematurity randomized trial.Archives of ophthalmology, 121 12
C. Dame, L. Sciesielski, Carolin Rau, Chiara-Aiyleen Badur, C. Bührer (2018)
The Erythropoietin Promoter Variant rs1617640 Is Not Associated with Severe Retinopathy of Prematurity, Independent of Treatment with ErythropoietinThe Journal of Pediatrics, 199
A. Stahl, T. Krohne, N. Eter, I. Oberacher-Velten, R. Guthoff, S. Meltendorf, O. Ehrt, S. Aisenbrey, J. Roider, H. Gerding, C. Jandeck, Lois Smith, J. Walz (2018)
Comparing Alternative Ranibizumab Dosages for Safety and Efficacy in Retinopathy of Prematurity: A Randomized Clinical TrialJAMA Pediatrics, 172
T. Colaizy, Susannah Longmuir, Kevin Gertsch, M. Abràmoff, J. Klein (2017)
Use of a Supplemental Oxygen Protocol to Suppress Progression of Retinopathy of Prematurity.Investigative ophthalmology & visual science, 58 2
Kinsey Ve (1956)
Retrolental fibroplasia; cooperative study of retrolental fibroplasia and the use of oxygen.Archives of Ophthalmology, 56
J. Sears, J. Pietz, C. Sonnie, D. Dolcini, G. Hoppe (2009)
A change in oxygen supplementation can decrease the incidence of retinopathy of prematurity.Ophthalmology, 116 3
J. Flynn, E. Bancalari (2000)
On "supplemental therapeutic oxygen for prethreshold retinopathy of prematurity (STOP-ROP), a randomized, controlled trial. I: Primary outcomes".Journal of AAPOS : the official publication of the American Association for Pediatric Ophthalmology and Strabismus, 4 2
John Moran, Mario Capecchi (2015)
Genomics in the neonatal nursery: Focus on ROP.Seminars in perinatology, 39 8
A. Patz (1984)
New international classification of retinopathy of prematurity.Pediatrics, 74 1
R. Stratton, W. Hauswirth, T. Gardner (2012)
Studies on Retinal and Choroidal Disorders
Early Treatment for Retinopathy of Prematurity Cooperative Group (2003)
10.1001/archopht.121.12.1684Arch Ophthalmol, 121
M. Hartnett, J. Penn (2012)
Mechanisms and management of retinopathy of prematurity.The New England journal of medicine, 367 26
Ryan Swan, S. Kim, J. Campbell, R. Chan, K. Sonmez, K. Taylor, Xiaohui Li, Y. Chen, J. Rotter, C. Simmons, M. Chiang (2018)
The genetics of retinopathy of prematurity: a model for neovascular retinal disease.Ophthalmology. Retina, 2 9
Carolyn Wu, D. Vanderveen, A. Hellström, C. Löfqvist, Lois Smith (2010)
Longitudinal postnatal weight measurements for the prediction of retinopathy of prematurity.Archives of ophthalmology, 128 4
D. Phelps (2013)
Supplemental Therapeutic Oxygen for Prethreshold Retinopathy of Prematurity (STOP-ROP), A Randomized, Controlled Trial. I: Primary Outcomes
D. Ley, B. Hallberg, I. Hansen-Pupp, C. Dani, L. Ramenghi, N. Marlow, K. Beardsall, F. Bhatti, D. Dunger, J. Higginson, A. Mahaveer, O. Mezu-Ndubuisi, P. Reynolds, C. Giannantonio, M. Weissenbruch, N. Barton, A. Tocoian, M. Hamdani, E. Jochim, A. Mangili, Jou-Ku Chung, M. Turner, Lois Smith, A. Hellström (2018)
rhIGF-1/rhIGFBP-3 in Preterm Infants: A Phase 2 Randomized Controlled TrialThe Journal of pediatrics, 206
Y. Saito, A. Uppal, G. Byfield, Steven Budd, M. Hartnett (2008)
Activated NAD(P)H oxidase from supplemental oxygen induces neovascularization independent of VEGF in retinopathy of prematurity model.Investigative ophthalmology & visual science, 49 4
J. Fiore, J. Bloom, F. Orge, A. Schutt, M. Schluchter, V. Cheruvu, M. Walsh, N. Finer, Richard Martin (2010)
A higher incidence of intermittent hypoxemic episodes is associated with severe retinopathy of prematurity.The Journal of pediatrics, 157 1
J. Chen, K. Connor, C. Aderman, K. Willett, O. Aspegren, Lois Smith (2009)
Suppression of retinal neovascularization by erythropoietin siRNA in a mouse model of proliferative retinopathy.Investigative ophthalmology & visual science, 50 3
Silke Becker, Haibo Wang, Aaron Simmons, Thipparat Suwanmanee, Gregory Stoddard, T. Kafri, M. Hartnett (2018)
Targeted Knockdown of Overexpressed VEGFA or VEGF164 in Müller cells maintains retinal function by triggering different signaling mechanismsScientific Reports, 8
K. Connor, J. Sangiovanni, Chatarina Lofqvist, C. Aderman, Jing Chen, A. Higuchi, Song Hong, Elke Pravda, Sharon Majchrzak, D. Carper, A. Hellstrom, J. Kang, E. Chew, N. Salem, C. Serhan, Lois Smith (2007)
Increased dietary intake of ω-3-polyunsaturated fatty acids reduces pathological retinal angiogenesisNature Medicine, 13
M. Hartnett (2017)
Electroretinographic Responses in the Smallest Eyes.JAMA ophthalmology, 135 8
M. Martinez-Castellanos, R. Vélez-Montoya, Kenneth Price, Andree Henaine-Berra, G. García-Aguirre, V. Morales-Canton, L. Cernichiaro-Espinosa (2017)
Vascular changes on fluorescein angiography of premature infants with low risk of retinopathy of prematurity after high oxygen exposureInternational Journal of Retina and Vitreous, 3
Silke Becker, Haibo Wang, Baifeng Yu, Randy Brown, Xiaokun Han, R. Lane, M. Hartnett (2017)
Protective effect of maternal uteroplacental insufficiency on oxygen-induced retinopathy in offspring: removing bias of premature birthScientific Reports, 7
K. Chang, T. Chan-Ling, E. McFarland, A. Afzal, Hao Pan, Louise Baxter, L. Shaw, S. Caballero, N. Sengupta, S. Calzi, S. Sullivan, M. Grant (2007)
IGF binding protein-3 regulates hematopoietic stem cell and endothelial precursor cell function during vascular developmentProceedings of the National Academy of Sciences, 104
Aaron Simmons, C. Bretz, Haibo Wang, Eric Kunz, Kassem Hajj, Carson Kennedy, Zhihong Yang, Thipparat Suwanmanee, T. Kafri, M. Hartnett (2018)
Gene therapy knockdown of VEGFR2 in retinal endothelial cells to treat retinopathyAngiogenesis, 21
J. Fiore, F. Kaffashi, K. Loparo, A. Sattar, M. Schluchter, Ryan Foglyano, Richard Martin, Christopher Wilson (2012)
The relationship between patterns of intermittent hypoxia and retinopathy of prematurity in preterm infantsPediatric Research, 72
G. Binenbaum, E. Bell, P. Donohue, G. Quinn, James Shaffer, L. Tomlinson, G. Ying (2018)
Development of Modified Screening Criteria for Retinopathy of Prematurity: Primary Results From the Postnatal Growth and Retinopathy of Prematurity StudyJAMA Ophthalmology, 136
M. Hartnett (2015)
Pathophysiology and mechanisms of severe retinopathy of prematurity.Ophthalmology, 122 1
Y. Saito, P. Geisen, A. Uppal, Elizabeth Hartnett (2007)
Inhibition of NAD(P)H oxidase reduces apoptosis and avascular retina in an animal model of retinopathy of prematurityMolecular Vision, 13
D. Lepore, G. Quinn, F. Molle, A. Baldascino, L. Orazi, M. Sammartino, V. Purcaro, C. Giannantonio, P. Papacci, C. Romagnoli (2014)
Intravitreal bevacizumab versus laser treatment in type 1 retinopathy of prematurity: report on fluorescein angiographic findings.Ophthalmology, 121 11
Lois Smith, W. Shen, C. Perruzzi, S. Soker, F. Kinose, Xianghong Xu, G. Robinson, Samuel Driver, J. Bischoff, Bei Zhang, J. Schaeffer, D. Senger (1999)
Regulation of vascular endothelial growth factor-dependent retinal neovascularization by insulin-like growth factor-1 receptorNature Medicine, 5
Anna Molnar, S. Andreasson, E. Larsson, H. Åkerblom, G. Holmström (2017)
Reduction of Rod and Cone Function in 6.5-Year-Old Children Born Extremely PretermJAMA Ophthalmology, 135
B. Schmidt, R. Whyte, E. Asztalos, D. Moddemann, C. Poets, Y. Rabi, A. Solimano, R. Roberts (2013)
Effects of targeting higher vs lower arterial oxygen saturations on death or disability in extremely preterm infants: a randomized clinical trial.JAMA, 309 20
D. Robertson, W. Petroll, H. Cavanagh (2008)
The effect of nonpreserved care solutions on 12 months of daily and extended silicone hydrogel contact lens wear.Investigative ophthalmology & visual science, 49 1
A. Patz, Ann Eastham (1953)
Oxygen studies in retrolental fibroplasia.The Proceedings of the Institute of Medicine of Chicago, 20 5
M. Hartnett, David Martiniuk, G. Byfield, P. Geisen, G. Zeng, V. Bautch (2008)
Neutralizing VEGF decreases tortuosity and alters endothelial cell division orientation in arterioles and veins in a rat model of ROP: relevance to plus disease.Investigative ophthalmology & visual science, 49 7
Sandra Juul, B. Comstock, R. Wadhawan, D. Mayock, Sherry Courtney, Tonya Robinson, K. Ahmad, Ellen Bendel-Stenzel, Mariana Baserga, Edmund LaGamma, L. Downey, Raghavendra Rao, Nancy Fahim, A. Lampland, Ivan III, Janine Khan, Michael Weiss, Maureen Gilmore, R. Ohls, N. Srinivasan, Jorge Perez, Victor McKay, Phuong Vu, Jean Lowe, K. Kuban, T. O’Shea, Adam Hartman, P. Heagerty (2020)
A Randomized Trial of Erythropoietin for Neuroprotection in Preterm Infants.The New England journal of medicine, 382 3
N. Ashton, B. Ward, G. Serpell (1954)
Effect of Oxygen on Developing Retinal Vessels with Particular Reference to the Problem of Retrolental FibroplasiaBritish Journal of Ophthalmology, 38
Sujata Rao, Christina Chun, Jieqing Fan, J. Kofron, Michael Yang, Michael Yang, R. Hegde, N. Ferrara, D. Copenhagen, Richard Lang, Richard Lang (2013)
A direct and melanopsin-dependent fetal light response regulates mouse eye developmentNature, 494
John Flynn, Eduardo Bancalari, Ellen Snyder, Ronald Goldberg, William Feuer, Janet Cassady, J. Schiffman, Harold Feldman, Brian Baghynski, Edward Buckley, Jacqueline Roberts, Dennis Gillings (1992)
A cohort study of transcutaneous oxygen tension and the incidence and severity of retinopathy of prematurity.Transactions of the American Ophthalmological Society, 89
Sw Terwilliger (2006)
15-Year outcomes following threshold retinopathy of prematurity: Final results from the Multicenter Trial of Cryotherapy for Retinopathy of Prematurity
J. Chen, K. Connor, C. Aderman, Lois Smith (2008)
Erythropoietin deficiency decreases vascular stability in mice.The Journal of clinical investigation, 118 2
Lois Smith, J. Kopchick, W. Chen, J. Knapp, F. Kinose, Douglas Daley, E. Foley, Roy Smith, J. Schaeffer (1997)
Essential role of growth hormone in ischemia-induced retinal neovascularization.Science, 276 5319
James Reynolds, R. Hardy, K. Kennedy, R. Spencer, W. Heuven, A. Fielder (1998)
Lack of efficacy of light reduction in preventing retinopathy of prematurity. Light Reduction in Retinopathy of Prematurity (LIGHT-ROP) Cooperative Group.The New England journal of medicine, 338 22
D. Austeng, K. Källén, U. Ewald, P. Jakobsson, G. Holmström (2009)
Incidence of retinopathy of prematurity in infants born before 27 weeks' gestation in Sweden.Archives of ophthalmology, 127 10
A. Hellström, A. Hård, E. Engström, A. Niklasson, Eva Andersson, Lois Smith, C. Löfqvist (2009)
Early Weight Gain Predicts Retinopathy in Preterm Infants: New, Simple, Efficient Approach to ScreeningPediatrics, 123
J. Mccolm, P. Geisen, M. Hartnett (2004)
VEGF isoforms and their expression after a single episode of hypoxia or repeated fluctuations between hyperoxia and hypoxia: relevance to clinical ROP.Molecular vision, 10
H. Mintz‐Hittner, K. Kennedy, A. Chuang (2011)
Efficacy of intravitreal bevacizumab for stage 3+ retinopathy of prematurity.The New England journal of medicine, 364 7
D. Austeng, K. Källén, A. Hellström, P. Jakobsson, Kent Johansson, K. Tornqvist, A. Wallin, G. Holmström (2009)
Screening for retinopathy of prematurity in infants born before 27 weeks' gestation in Sweden.Archives of ophthalmology, 129 2
P. Sapieha (2012)
Eyeing central neurons in vascular growth and reparative angiogenesis.Blood, 120 11
B. Stenson, W. Tarnow-Mordi, B. Darlow, J. Simes, E. Juszczak, L. Askie, M. Battin, U. Bowler, R. Broadbent, P. Cairns, P. Davis, S. Deshpande, M. Donoghoe, L. Doyle, B. Fleck, Alpana Ghadge, W. Hague, H. Halliday, Michael Hewson, A. King, A. Kirby, N. Marlow, M. Meyer, C. Morley, K. Simmer, W. Tin, S. Wardle, P. Brocklehurst (2013)
Oxygen saturation and outcomes in preterm infants.The New England journal of medicine, 368 22
S. Najm, C. Löfqvist, G. Hellgren, E. Engström, P. Lundgren, A. Hård, A. Lapillonne, K. Sävman, A. Nilsson, M. Andersson, Lois Smith, A. Hellström (2017)
Effects of a lipid emulsion containing fish oil on polyunsaturated fatty acid profiles, growth and morbidities in extremely premature infants: A randomized controlled trialClinical nutrition ESPEN, 20
Michael Yang, Sujata Rao, D. Copenhagen, R. Lang (2013)
Length of day during early gestation as a predictor of risk for severe retinopathy of prematurity.Ophthalmology, 120 12
H. Kondo, S. Kusaka, Aki Yoshinaga, E. Uchio, A. Tawara, T. Tahira (2013)
Genetic variants of FZD4 and LRP5 genes in patients with advanced retinopathy of prematurityMolecular Vision, 19
D. Wallace, R. Kraker, S. Freedman, E. Crouch, A. Hutchinson, Amit Bhatt, David Rogers, Michael Yang, Kathryn Haider, D. Vanderveen, R. Siatkowski, Trevano Dean, R. Beck, M. Repka, Lois Smith, W. Good, M. Hartnett, L. Kong, J. Holmes (2017)
Assessment of Lower Doses of Intravitreous Bevacizumab for Retinopathy of Prematurity: A Phase 1 Dosing StudyJAMA Ophthalmology, 135
A. Hellström, E. Engström, A. Hård, K. Albertsson-Wikland, B. Carlsson, A. Niklasson, C. Löfqvist, E. Svensson, S. Holm, U. Ewald, G. Holmström, Lois Smith (2003)
Postnatal serum insulin-like growth factor I deficiency is associated with retinopathy of prematurity and other complications of premature birth.Pediatrics, 112 5
Vishak John, Jedediah McClintic, D. Hess, A. Berrocal (2016)
Retinopathy of Prematurity Versus Familial Exudative Vitreoretinopathy: Report on Clinical and Angiographic Findings.Ophthalmic surgery, lasers & imaging retina, 47 1
M. Brines, A. Cerami (2006)
Discovering erythropoietin's extra-hematopoietic functions: biology and clinical promise.Kidney international, 70 2
M. Klufas, Samir Patel, Michael Ryan, Mrinali Gupta, Karyn Jonas, S. Ostmo, M. Martinez-Castellanos, A. Berrocal, M. Chiang, R. Chan (2015)
Influence of Fluorescein Angiography on the Diagnosis and Management of Retinopathy of Prematurity.Ophthalmology, 122 8
M. Gaynon, R. Wong, D. Stevenson, P. Sunshine (2018)
Prethreshold retinopathy of prematurity: VEGF inhibition without VEGF inhibitorsJournal of Perinatology, 38
J. York, S. Landers, R. Kirby, P. Arbogast, J. Penn (2004)
Arterial Oxygen Fluctuation and Retinopathy of Prematurity in Very-Low-Birth-Weight InfantsJournal of Perinatology, 24
J. Sears, G. Hoppe, Q. Ebrahem, B. Anand-Apte (2008)
Prolyl hydroxylase inhibition during hyperoxia prevents oxygen-induced retinopathyProceedings of the National Academy of Sciences, 105
[The pathophysiology of retinopathy of prematurity (ROP) is evolving as advances in prenatal care allow extremely premature infants to survive. In addition, throughout the world, there is variability in the presentations of ROP. In regions that lack resources to support prenatal and perinatal care, ROP develops in infants of older gestational ages and larger birth weights and has potentially different pathophysiologic factors. This chapter will review the pathophysiology of ROP and factors involved in the presentation of ROP based on what is known through clinical studies and from experimental studies using animal models of oxygen-induced retinopathy (OIR), which are critical to study molecular mechanisms and cell–cell interactions. Although the main areas involve clinical study, it is impossible to discuss pathophysiology without including evidence from the most representative animal models of oxygen-induced retinopathy (OIR) and other models adapted to study maternal–fetal interactions. Understanding the role of vascular endothelial growth factor (VEGF) in the physiology of retinal and vascular development and survival and the pathology in stage 3 and plus disease of ROP is important in discussing pathophysiology. Thoughts regarding areas of future study will be briefly described.]
Published: Jan 19, 2021
Keywords: Retinal angiogenesis; Pathophysiology of ROP; Vascular endothelial growth factor (VEGF); Reactive oxygen; Oxidative stress; Erythropoietin; ROP phases; Angiogenesis; Oxygen fluctuations; IGF-1
Read and print from thousands of top scholarly journals.
Already have an account? Log in
Bookmark this article. You can see your Bookmarks on your DeepDyve Library.
To save an article, log in first, or sign up for a DeepDyve account if you don’t already have one.
Copy and paste the desired citation format or use the link below to download a file formatted for EndNote
Access the full text.
Sign up today, get DeepDyve free for 14 days.
All DeepDyve websites use cookies to improve your online experience. They were placed on your computer when you launched this website. You can change your cookie settings through your browser.