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A Short History of the Drug Receptor ConceptThe Development of the Concept of Drug Receptors in the Physiological Research of John Newport Langley

A Short History of the Drug Receptor Concept: The Development of the Concept of Drug Receptors in... [Whilst Paul Ehrlich was effectively the first to develop a receptor concept in the context of immunology, it was the Cambridge physiologist, John Newport Langley (1852–1925) who first proposed a receptor theory for the action of drugs and transmitter substances in the body. In this chapter we discuss how Langley developed, over a period of 30 years and in diverse research contexts, his ideas on the mode of action of drugs and physiological substances on tissues and cells. In 1905 these ideas culminated in the first full formulation of his concept of ‘receptive substances’ in cells.1 We will also consider the influence of other British and Continental European scientists on Langley’s thought and experimentation, and how his research themes were linked to other work in the Cambridge physiological laboratory and to the development of his academic career.] http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png

A Short History of the Drug Receptor ConceptThe Development of the Concept of Drug Receptors in the Physiological Research of John Newport Langley

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Publisher
Palgrave Macmillan UK
Copyright
© Palgrave Macmillan, a division of Macmillan Publishers Limited 2009
ISBN
978-1-349-36377-3
Pages
41 –63
DOI
10.1057/9780230583740_3
Publisher site
See Chapter on Publisher Site

Abstract

[Whilst Paul Ehrlich was effectively the first to develop a receptor concept in the context of immunology, it was the Cambridge physiologist, John Newport Langley (1852–1925) who first proposed a receptor theory for the action of drugs and transmitter substances in the body. In this chapter we discuss how Langley developed, over a period of 30 years and in diverse research contexts, his ideas on the mode of action of drugs and physiological substances on tissues and cells. In 1905 these ideas culminated in the first full formulation of his concept of ‘receptive substances’ in cells.1 We will also consider the influence of other British and Continental European scientists on Langley’s thought and experimentation, and how his research themes were linked to other work in the Cambridge physiological laboratory and to the development of his academic career.]

Published: Sep 25, 2015

Keywords: Nerve Fibre; Sympathetic Nerve; Nerve Ending; Myoneural Junction; Gland Cell

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