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A Strategic Approach to Knee Arthritis TreatmentStructure, Function, and Healing Response of Articular Cartilage and Meniscus

A Strategic Approach to Knee Arthritis Treatment: Structure, Function, and Healing Response of... [Articular cartilage is a tissue that forms the surface of the joint, which reduces friction during the lifetime and enables the synovial joint to perform the painless joint movement. Articular cartilage consists of a rich matrix and specially differentiated chondrocytes sparsely distributed between them. The articular cartilage matrix protects chondrocytes from damage that may occur due to normal joint movement, provides elasticity to the joints, provides a lubrication system for low-friction movements between the synovial fluid and the cartilage, and regulates the movement of matrix macromolecules throughout life. However, with age, chondrocytes gradually lose their ability, and given repeated damage, cartilage dysfunction eventually leads to osteoarthritis. The meniscus is two crescent-shaped fibrocartilage structures between the femoral condyle and tibial plateau. The meniscus is the primary stabilizing structure of the knee joint having important functions such as load transmission, absorb shock, joint stability and lubrication. The inner two-third of the meniscus is a relatively avascular structure and is not well recover when torn. Since only the peripheral part of the meniscus has the ability to heal, the location of the tear is the most important factor in restoring the torn meniscus. However, in order to overcome this, several studies are being conducted that can improve the healing potential in the torn meniscus.] http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png

A Strategic Approach to Knee Arthritis TreatmentStructure, Function, and Healing Response of Articular Cartilage and Meniscus

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References (45)

Publisher
Springer Singapore
Copyright
© The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer Nature Singapore Pte Ltd. 2021
ISBN
978-981-16-4216-6
Pages
35 –54
DOI
10.1007/978-981-16-4217-3_2
Publisher site
See Chapter on Publisher Site

Abstract

[Articular cartilage is a tissue that forms the surface of the joint, which reduces friction during the lifetime and enables the synovial joint to perform the painless joint movement. Articular cartilage consists of a rich matrix and specially differentiated chondrocytes sparsely distributed between them. The articular cartilage matrix protects chondrocytes from damage that may occur due to normal joint movement, provides elasticity to the joints, provides a lubrication system for low-friction movements between the synovial fluid and the cartilage, and regulates the movement of matrix macromolecules throughout life. However, with age, chondrocytes gradually lose their ability, and given repeated damage, cartilage dysfunction eventually leads to osteoarthritis. The meniscus is two crescent-shaped fibrocartilage structures between the femoral condyle and tibial plateau. The meniscus is the primary stabilizing structure of the knee joint having important functions such as load transmission, absorb shock, joint stability and lubrication. The inner two-third of the meniscus is a relatively avascular structure and is not well recover when torn. Since only the peripheral part of the meniscus has the ability to heal, the location of the tear is the most important factor in restoring the torn meniscus. However, in order to overcome this, several studies are being conducted that can improve the healing potential in the torn meniscus.]

Published: Oct 13, 2021

Keywords: Articular cartilage; Chondrocyte; Synovial fluid; Lubrication; Matrix macromolecules; Meniscus; Fibrocartilage; Load transmission; Absorb shock

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