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/lp/springer-journals/a-systems-biology-approach-to-study-metabolic-syndrome-systems-biology-0VVxxuEDIG
- Publisher
- Springer International Publishing
- Copyright
- © Springer International Publishing Switzerland 2014
- ISBN
- 978-3-319-01007-6
- Pages
- 17 –23
- DOI
- 10.1007/978-3-319-01008-3_2
- Publisher site
- See Chapter on Publisher Site
Abstract
[If we are to study complex multi-factorial disorders such as Metabolic Syndrome (MetS) by applying the state-of-the-art ‘omics’ technologies, the reductionist approach commonly applied in life sciences is no longer suitable. In order to understand the adaptive changes in molecular networks in different stages of the disease pathogenesis, a comprehensive view of the system is needed because activation of different pathways may still lead to the same functionality, but with different metabolic costs. Systems biology emerged as an inter-disciplinary field of study that focuses on complex interactions within and between biological systems, using a more holistic perspective approach to biological and biomedical research. While the importance of the systems approach has already been recognized decades ago, the experimental and modeling techniques have matured to the level where comprehensive characterization of biological systems at the molecular level is now feasible.]
Published: Sep 25, 2013
Keywords: Allostasis; Allostatic load; Bioinformatics; Genomics; Gut microbiota; Lipid metabolism; Metabolic networks; Metabolomics; Proteomics; Systems biology