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A Systems Biology Approach to Study Metabolic SyndromeThe Metabolic Syndrome and its Complex Pathophysiology

A Systems Biology Approach to Study Metabolic Syndrome: The Metabolic Syndrome and its Complex... [The Metabolic Syndrome (MetS) represents the association of common pathologies such as obesity, diabetes, insulin resistance, dyslipidaemia, fatty liver and associated cardiovascular complications. The MetS is important because of its prevalence, potential severity and costs. The MetS is a challenge due to its undefined pathogenesis, clinical heterogeneity and complexity, lack of good risk predictors and therapeutic options. Here we propose an adipocentric pathogenic model supported by the concepts of adipose tissue expandability and peripheral lipotoxicity. We also put forward the need for an allostatic perspective and a systems biology approach to understand its pathogenesis, natural history, subphenotypes, potential diagnostic and prognostic biomarkers and new therapeutic targets.] http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png

A Systems Biology Approach to Study Metabolic SyndromeThe Metabolic Syndrome and its Complex Pathophysiology

Editors: Orešič, Matej; Vidal-Puig, Antonio
Vidal-Puig, Antonio
A Systems Biology Approach to Study Metabolic Syndrome — Sep 25, 2013
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Publisher
Springer International Publishing
Copyright
© Springer International Publishing Switzerland 2014
ISBN
978-3-319-01007-6
Pages
3 –16
DOI
10.1007/978-3-319-01008-3_1
Publisher site
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Abstract

[The Metabolic Syndrome (MetS) represents the association of common pathologies such as obesity, diabetes, insulin resistance, dyslipidaemia, fatty liver and associated cardiovascular complications. The MetS is important because of its prevalence, potential severity and costs. The MetS is a challenge due to its undefined pathogenesis, clinical heterogeneity and complexity, lack of good risk predictors and therapeutic options. Here we propose an adipocentric pathogenic model supported by the concepts of adipose tissue expandability and peripheral lipotoxicity. We also put forward the need for an allostatic perspective and a systems biology approach to understand its pathogenesis, natural history, subphenotypes, potential diagnostic and prognostic biomarkers and new therapeutic targets.]

Published: Sep 25, 2013

Keywords: Obesity; Insulin resistance; Lipotoxicity; Inflammation; Adipose tissue expandability; Allostasis

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