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A Time for Metabolism and HormonesThe Epigenetic and Metabolic Language of the Circadian Clock

A Time for Metabolism and Hormones: The Epigenetic and Metabolic Language of the Circadian Clock [The circadian clock controls a large variety of neuronal, endocrine, behavioral and physiological responses in mammals. This control is exerted in large part at the transcriptional level on genes expressed in a cyclic manner. A highly specialized transcriptional machinery based on clock regulatory factors organized in feedback autoregulatory loops governs a significant portion of the genome. These oscillations in gene expression are paralleled by critical events of chromatin remodeling that appear to provide plasticity to circadian regulation. Specifically, the NAD+-dependent deacetylases SIRT1 and SIRT6 have been linked to circadian control of gene expression. This and additional accumulating evidence shows that the circadian epigenome appears to share intimate links with cellular metabolic processes and has remarkable plasticity, showing reprogramming in response to nutritional challenges. In addition to SIRT1 and SIRT6, a number of chromatin remodelers have been implicated in clock control, including the histone H3K4 tri-methyltransferase MLL1. Deciphering the molecular mechanisms that link metabolism, epigenetic control and circadian responses will provide valuable insights towards innovative strategies of therapeutic intervention.] http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png

A Time for Metabolism and HormonesThe Epigenetic and Metabolic Language of the Circadian Clock

Editors: Sassone-Corsi, Paolo; Christen, Yves

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References (64)

Publisher
Springer International Publishing
Copyright
© The Editor(s) (if applicable) and the Author(s) 2016. This book is published open access.
ISBN
978-3-319-27068-5
Pages
1 –11
DOI
10.1007/978-3-319-27069-2_1
Publisher site
See Chapter on Publisher Site

Abstract

[The circadian clock controls a large variety of neuronal, endocrine, behavioral and physiological responses in mammals. This control is exerted in large part at the transcriptional level on genes expressed in a cyclic manner. A highly specialized transcriptional machinery based on clock regulatory factors organized in feedback autoregulatory loops governs a significant portion of the genome. These oscillations in gene expression are paralleled by critical events of chromatin remodeling that appear to provide plasticity to circadian regulation. Specifically, the NAD+-dependent deacetylases SIRT1 and SIRT6 have been linked to circadian control of gene expression. This and additional accumulating evidence shows that the circadian epigenome appears to share intimate links with cellular metabolic processes and has remarkable plasticity, showing reprogramming in response to nutritional challenges. In addition to SIRT1 and SIRT6, a number of chromatin remodelers have been implicated in clock control, including the histone H3K4 tri-methyltransferase MLL1. Deciphering the molecular mechanisms that link metabolism, epigenetic control and circadian responses will provide valuable insights towards innovative strategies of therapeutic intervention.]

Published: Apr 5, 2016

Keywords: Circadian Clock; Flavin Adenine Dinucleotide; Clock Protein; Circadian Control; Clock Function

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