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- Publisher
- Springer International Publishing
- Copyright
- © Springer International Publishing Switzerland 2015
- ISBN
- 978-3-319-13265-5
- Pages
- 1 –15
- DOI
- 10.1007/978-3-319-13266-2_1
- Publisher site
- See Chapter on Publisher Site
Abstract
[Cartilage and bone tissue formation is observed not only during embryonic development but also in some pathological conditions occurring after birth, including fracture healing. This process is regulated by many stimuli that are applicable to the reconstitution of skeletal tissues using tissue engineering. In particular, members of the transforming growth factor (TGF)-β family play a unique and important role in skeletal tissue formation, wherein they activate specific intracellular signaling pathways by binding two types of serine–threonine kinase receptors and downstream effectors called Smad proteins. The biological activity of TGF-β family members is positively and negatively regulated at multiple steps by various molecules found in the extracellular space, on the cell membrane, and in the intracellular space. The modification of TGF-β family signaling pathways can be used in tissue engineering approaches for skeletal tissue formation.]
Published: Dec 6, 2014
Keywords: Bone Morphogenetic Protein; Osteoblastic Differentiation; C2C12 Cell; Demineralized Bone Matrix; Ectopic Bone Formation