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A Tissue Regeneration Approach to Bone and Cartilage RepairSkeletal Stem Cells for Bone and Cartilage Tissue Regeneration

A Tissue Regeneration Approach to Bone and Cartilage Repair: Skeletal Stem Cells for Bone and... [There is an increasing interest in using stem cells in treatment of degenerative diseases such as Parkinson’s disease, liver failure, leukemia, diabetes, osteoarthritis (OA), and osteoporosis, for which there is no curative therapy. In this context, skeletal tissue regeneration is being addressed for a number of common clinical conditions including repair of non-healing fractures and bone defects through transplantation of skeletal stem cells (also known as stromal or adult or mesenchymal stem cells, MSCs) either alone or with osteoinductive/osteoconductive scaffolds. In the present Chapter, we will present biological characteristics of MSCs and will give an update regarding their use in skeletal tissue regeneration in preclinical animal models and in clinical trials.] http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png

A Tissue Regeneration Approach to Bone and Cartilage RepairSkeletal Stem Cells for Bone and Cartilage Tissue Regeneration

Part of the Mechanical Engineering Series Book Series
Editors: Zreiqat, Hala; Dunstan, Colin R.; Rosen, Vicki

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References (63)

Publisher
Springer International Publishing
Copyright
© Springer International Publishing Switzerland 2015
ISBN
978-3-319-13265-5
Pages
53 –63
DOI
10.1007/978-3-319-13266-2_4
Publisher site
See Chapter on Publisher Site

Abstract

[There is an increasing interest in using stem cells in treatment of degenerative diseases such as Parkinson’s disease, liver failure, leukemia, diabetes, osteoarthritis (OA), and osteoporosis, for which there is no curative therapy. In this context, skeletal tissue regeneration is being addressed for a number of common clinical conditions including repair of non-healing fractures and bone defects through transplantation of skeletal stem cells (also known as stromal or adult or mesenchymal stem cells, MSCs) either alone or with osteoinductive/osteoconductive scaffolds. In the present Chapter, we will present biological characteristics of MSCs and will give an update regarding their use in skeletal tissue regeneration in preclinical animal models and in clinical trials.]

Published: Dec 6, 2014

Keywords: Skeletal stem cell; Regenerative medicine; Osteogenesis; Bone diseases; Fracture; Scaffold

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