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A unified vision of the building blocks of life

A unified vision of the building blocks of life coRRespondence Jamey D. Marth To the e ditor: Glycans From the discovery of DNA to the sequencing Nucleic acids (DNA and RNA) of the human genome, the template-dependent formation of biological molecules from gene to RNA and protein has been the central tenet of biology. Yet the origins of many diseases, includ- ing allergy, Alzheimer’s disease, asthma, autism, diabetes, inflammatory bowel disease, Lou Deoxyadenosine, deoxycytidine, Fucose, galactose, glucose, glucuronic acid, mannose, deoxyguanosine, deoxythymidine, Gehrig’s disease, multiple sclerosis, Parkinson’s N-acetylgalactosamine, N-acetylglucosamine, neuraminic acid, xylose, adenosine, cytidine, guanosine, uridine nononic acid, octulosonic acid, arabinose, arabinofuranose, disease and rheumatoid arthritis, continue to colitose, fructose, galactofuranose, galacturonic acid, evade our understanding. Expectations that glucolactilic acid, heptose, legionaminic acid, mannuronic acid, N-acetylfucosamine, N-acetylgalacturonic acid, defined variation in the DNA blueprint would N-acetylmannosamine, N-acetylmannosaminuronic acid, N-acetylmuramic acid, N-acetylperosamine, serve to pinpoint even multigenic causes of N-acetylquinovosamine, perosamine, these diseases remain unfulfilled. Studies of pseudaminic acid, rhamnose, talose distinct populations have implicated differ- ent genes, and those genes that are identified contribute to disease in a small fraction of the 1–3 individuals diagnosed . The genetic parts list seems insufficient to account for the origin of many grievous illnesses. Environmental factors dA, dC, dG, dT, rA, http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Nature Cell Biology Springer Journals

A unified vision of the building blocks of life

Nature Cell Biology , Volume 10 (9) – Sep 1, 2008

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References (9)

Publisher
Springer Journals
Copyright
Copyright © 2008 by Nature Publishing Group
Subject
Life Sciences; Life Sciences, general; Cell Biology; Cancer Research; Developmental Biology; Stem Cells
ISSN
1465-7392
eISSN
1476-4679
DOI
10.1038/ncb0908-1015
Publisher site
See Article on Publisher Site

Abstract

coRRespondence Jamey D. Marth To the e ditor: Glycans From the discovery of DNA to the sequencing Nucleic acids (DNA and RNA) of the human genome, the template-dependent formation of biological molecules from gene to RNA and protein has been the central tenet of biology. Yet the origins of many diseases, includ- ing allergy, Alzheimer’s disease, asthma, autism, diabetes, inflammatory bowel disease, Lou Deoxyadenosine, deoxycytidine, Fucose, galactose, glucose, glucuronic acid, mannose, deoxyguanosine, deoxythymidine, Gehrig’s disease, multiple sclerosis, Parkinson’s N-acetylgalactosamine, N-acetylglucosamine, neuraminic acid, xylose, adenosine, cytidine, guanosine, uridine nononic acid, octulosonic acid, arabinose, arabinofuranose, disease and rheumatoid arthritis, continue to colitose, fructose, galactofuranose, galacturonic acid, evade our understanding. Expectations that glucolactilic acid, heptose, legionaminic acid, mannuronic acid, N-acetylfucosamine, N-acetylgalacturonic acid, defined variation in the DNA blueprint would N-acetylmannosamine, N-acetylmannosaminuronic acid, N-acetylmuramic acid, N-acetylperosamine, serve to pinpoint even multigenic causes of N-acetylquinovosamine, perosamine, these diseases remain unfulfilled. Studies of pseudaminic acid, rhamnose, talose distinct populations have implicated differ- ent genes, and those genes that are identified contribute to disease in a small fraction of the 1–3 individuals diagnosed . The genetic parts list seems insufficient to account for the origin of many grievous illnesses. Environmental factors dA, dC, dG, dT, rA,

Journal

Nature Cell BiologySpringer Journals

Published: Sep 1, 2008

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