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[Adenosine is an important metabolite and a building block for many biologically relevant molecules. Most abundantly, it contributes the purine base adenine and a ribose to ATP which as an energy-providing compound occurs in millimolar concentrations in every cell. Such high concentrations of ATP are the basis for functionally significant levels of adenosine to occur in all cells and in the extracellular space. Adenosine concentrations vary widely in tissues and body fluids as it is formed both intra- and extracellularly, it undergoes metabolism by adenosine deaminase and adenosine kinase, and may be transported through the plasma membrane with equilibrative and concentrative types of transporter proteins.]
Published: Nov 6, 2009
Keywords: Extracellular space; cardiovascular system; adenosine receptors subtype; hypoxia; tumor; receptor-mediated response; hypoxia-mediated changes in adenosine concentrations
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