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A3 Adenosine Receptors from Cell Biology to Pharmacology and TherapeuticsPharmacology and Molecular Biology of A3 Adenosine Receptors

A3 Adenosine Receptors from Cell Biology to Pharmacology and Therapeutics: Pharmacology and... [Adenosine is an important metabolite and a building block for many biologically relevant molecules. Most abundantly, it contributes the purine base adenine and a ribose to ATP which as an energy-providing compound occurs in millimolar concentrations in every cell. Such high concentrations of ATP are the basis for functionally significant levels of adenosine to occur in all cells and in the extracellular space. Adenosine concentrations vary widely in tissues and body fluids as it is formed both intra- and extracellularly, it undergoes metabolism by adenosine deaminase and adenosine kinase, and may be transported through the plasma membrane with equilibrative and concentrative types of transporter proteins.] http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png

A3 Adenosine Receptors from Cell Biology to Pharmacology and TherapeuticsPharmacology and Molecular Biology of A3 Adenosine Receptors

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References (60)

Publisher
Springer Netherlands
Copyright
© Springer Science+Business Media B.V. 2010
ISBN
978-90-481-3143-3
Pages
49 –58
DOI
10.1007/978-90-481-3144-0_3
Publisher site
See Chapter on Publisher Site

Abstract

[Adenosine is an important metabolite and a building block for many biologically relevant molecules. Most abundantly, it contributes the purine base adenine and a ribose to ATP which as an energy-providing compound occurs in millimolar concentrations in every cell. Such high concentrations of ATP are the basis for functionally significant levels of adenosine to occur in all cells and in the extracellular space. Adenosine concentrations vary widely in tissues and body fluids as it is formed both intra- and extracellularly, it undergoes metabolism by adenosine deaminase and adenosine kinase, and may be transported through the plasma membrane with equilibrative and concentrative types of transporter proteins.]

Published: Nov 6, 2009

Keywords: Extracellular space; cardiovascular system; adenosine receptors subtype; hypoxia; tumor; receptor-mediated response; hypoxia-mediated changes in adenosine concentrations

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