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ABC Transporters - 40 Years onABC Importers

ABC Transporters - 40 Years on: ABC Importers [Most ABC importers employ a soluble substrate-binding protein (SBP) to capture the ligand and donate the molecule to the translocator. The SBP can be a soluble periplasmic protein or tethered to the membrane via a lipid moiety or protein anchor or fused to the translocator. In the hybrid ABC transporters, multiple substrate-binding domains (SBDs) can be fused in tandem and provide several extracytoplasmic substrate-binding sites. The substrate is transferred from the SBP to the membrane domain, which translocates the substrate via alternating access of a membrane-embedded substrate-binding pocket. A subset of ABC transporters, known as the energy-coupling factor (ECF) transporters, employs a membrane-embedded S-component to capture the substrate. The S-component guided by the ECF module transports the substrate over the membrane via a so-called toppling mechanism. An overview of the mechanisms of transport by the different types of ABC importers is presented, together with structural information about the proteins.] http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png

ABC Transporters - 40 Years onABC Importers

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Publisher
Springer International Publishing
Copyright
© Springer International Publishing Switzerland 2016
ISBN
978-3-319-23475-5
Pages
3 –36
DOI
10.1007/978-3-319-23476-2_1
Publisher site
See Chapter on Publisher Site

Abstract

[Most ABC importers employ a soluble substrate-binding protein (SBP) to capture the ligand and donate the molecule to the translocator. The SBP can be a soluble periplasmic protein or tethered to the membrane via a lipid moiety or protein anchor or fused to the translocator. In the hybrid ABC transporters, multiple substrate-binding domains (SBDs) can be fused in tandem and provide several extracytoplasmic substrate-binding sites. The substrate is transferred from the SBP to the membrane domain, which translocates the substrate via alternating access of a membrane-embedded substrate-binding pocket. A subset of ABC transporters, known as the energy-coupling factor (ECF) transporters, employs a membrane-embedded S-component to capture the substrate. The S-component guided by the ECF module transports the substrate over the membrane via a so-called toppling mechanism. An overview of the mechanisms of transport by the different types of ABC importers is presented, together with structural information about the proteins.]

Published: Dec 17, 2015

Keywords: Maltose Transporter; Periplasmic Side; Methanosarcina Acetivorans; Glycosyl Unit; Thermoanaerobacter Tengcongensis

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