ABC Transporters - 40 Years on: ABC Importers
Swier, Lotteke J. Y. M.; Slotboom, Dirk-Jan; Poolman, Bert
2015-12-17 00:00:00
[Most ABC importers employ a soluble substrate-binding protein (SBP) to capture the ligand and donate the molecule to the translocator. The SBP can be a soluble periplasmic protein or tethered to the membrane via a lipid moiety or protein anchor or fused to the translocator. In the hybrid ABC transporters, multiple substrate-binding domains (SBDs) can be fused in tandem and provide several extracytoplasmic substrate-binding sites. The substrate is transferred from the SBP to the membrane domain, which translocates the substrate via alternating access of a membrane-embedded substrate-binding pocket. A subset of ABC transporters, known as the energy-coupling factor (ECF) transporters, employs a membrane-embedded S-component to capture the substrate. The S-component guided by the ECF module transports the substrate over the membrane via a so-called toppling mechanism. An overview of the mechanisms of transport by the different types of ABC importers is presented, together with structural information about the proteins.]
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[Most ABC importers employ a soluble substrate-binding protein (SBP) to capture the ligand and donate the molecule to the translocator. The SBP can be a soluble periplasmic protein or tethered to the membrane via a lipid moiety or protein anchor or fused to the translocator. In the hybrid ABC transporters, multiple substrate-binding domains (SBDs) can be fused in tandem and provide several extracytoplasmic substrate-binding sites. The substrate is transferred from the SBP to the membrane domain, which translocates the substrate via alternating access of a membrane-embedded substrate-binding pocket. A subset of ABC transporters, known as the energy-coupling factor (ECF) transporters, employs a membrane-embedded S-component to capture the substrate. The S-component guided by the ECF module transports the substrate over the membrane via a so-called toppling mechanism. An overview of the mechanisms of transport by the different types of ABC importers is presented, together with structural information about the proteins.]
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