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Abdominal Neuroendocrine TumorsNeuroendocrine Tumors: a Nosologic Framework

Abdominal Neuroendocrine Tumors: Neuroendocrine Tumors: a Nosologic Framework Neuroendocrine Tumors: 1 1 a Nosologic Framework Massimo Carlini and Marialuisa Appetecchia 1.1 Neuroendocrine Cells of the Digestive System The neuroendocrine system is a network of cells distributed throughout the hu- man body, having structure similar to nerve cells (neurons) and releasing hor- mones into the bloodstream like endocrine cells. These hormones work like neurotransmitters and are released to transmit signals or impulses to other spe- cialized or nerve cells. The gastrointestinal (GI) tract and pancreatobiliary system contain a variety of endocrine cells that constitute a diffuse endocrine system. This is the largest population of hormone-producing cells in the body [1]. Specialized endoderm- derived epithelial cells, called enteroendocrine cells (EECs), are widely distrib- uted throughout the GI tract [2, 3]. Intestinal EECs are restricted to the mucosa and represent only a small minority (<1%) of the overall epithelial cell popula- tion, often lying isolated from one another and interspersed by non-endocrine epithelial cells. These cells produce and release hormones [4] and play a key role in the control of GI secretion and motility, regulation of food intake, postpran- dial glucose levels and metabolism. When EECs interact with luminal content, they release signal molecules which can enter the circulation and http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png

Abdominal Neuroendocrine TumorsNeuroendocrine Tumors: a Nosologic Framework

Part of the Updates in Surgery Book Series
Editors: Carlini, Massimo
Carlini, Massimo; Appetecchia, Marialuisa
Abdominal Neuroendocrine Tumors — Sep 22, 2017
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References (78)

Publisher
Springer Milan
Copyright
© Springer-Verlag Italia Srl. 2018
ISBN
978-88-470-3954-4
Pages
3 –19
DOI
10.1007/978-88-470-3955-1_1
Publisher site
See Chapter on Publisher Site

Abstract

Neuroendocrine Tumors: 1 1 a Nosologic Framework Massimo Carlini and Marialuisa Appetecchia 1.1 Neuroendocrine Cells of the Digestive System The neuroendocrine system is a network of cells distributed throughout the hu- man body, having structure similar to nerve cells (neurons) and releasing hor- mones into the bloodstream like endocrine cells. These hormones work like neurotransmitters and are released to transmit signals or impulses to other spe- cialized or nerve cells. The gastrointestinal (GI) tract and pancreatobiliary system contain a variety of endocrine cells that constitute a diffuse endocrine system. This is the largest population of hormone-producing cells in the body [1]. Specialized endoderm- derived epithelial cells, called enteroendocrine cells (EECs), are widely distrib- uted throughout the GI tract [2, 3]. Intestinal EECs are restricted to the mucosa and represent only a small minority (<1%) of the overall epithelial cell popula- tion, often lying isolated from one another and interspersed by non-endocrine epithelial cells. These cells produce and release hormones [4] and play a key role in the control of GI secretion and motility, regulation of food intake, postpran- dial glucose levels and metabolism. When EECs interact with luminal content, they release signal molecules which can enter the circulation and

Published: Sep 22, 2017

Keywords: Neuroendocrine Tumors (NETs); Gastric NETs; SEER Population; Surveillance, Epidemiology, And End Results (SEER); Multiple Endocrine Neoplasia (MEN1)

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