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Editorial: Effects of an Oral Vitamin B12 on HIV Affected Individuals

Editorial: Effects of an Oral Vitamin B12 on HIV Affected Individuals Journal of Advancement in Medicine Volume 12, Number 2, Summer 1999 Editorial: Effects of an Oral Vitamin B12 on HIV Affected Individuals The paper by Brennan and associates requires comment. They report a study of an uncontrolled trial of an orally active preparation con- taining B12 in the symptomatic treatment of HIV affected individ- uals. Only 10 subjects completed the study and the results were ob- tained by patient questionnaires. Eight subjects were already taking a multivitamin that contained B12 and, in addition four of them were receiving B12 in another form, by intramuscular injection in three and in tablet form in one. On the face of it, the study might be considered to be unpublishable since the confounding factors are so obvious, but there are some re- deeming features that make it worth bringing to the attention of practicing physicians. This is strictly an "Outcomes" study, perhaps the methodology that is gradually going to replace the cumbersome and potentially fallacious double blind controlled study that has long been the "gold standard" of clinical research. Admittedly, no attempt was made to give the results statistical validity, but the small num- ber of subjects precludes that and rather it should http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Journal of Advancement in Medicine Springer Journals

Editorial: Effects of an Oral Vitamin B12 on HIV Affected Individuals

Journal of Advancement in Medicine , Volume 12 (2) – Sep 30, 2004
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Publisher
Springer Journals
Copyright
Copyright © 1999 by Human Sciences Press, Inc.
Subject
Medicine & Public Health; Public Health
ISSN
0894-5888
eISSN
1573-9767
DOI
10.1023/B:JAME.0000009331.89060.28
Publisher site
See Article on Publisher Site

Abstract

Journal of Advancement in Medicine Volume 12, Number 2, Summer 1999 Editorial: Effects of an Oral Vitamin B12 on HIV Affected Individuals The paper by Brennan and associates requires comment. They report a study of an uncontrolled trial of an orally active preparation con- taining B12 in the symptomatic treatment of HIV affected individ- uals. Only 10 subjects completed the study and the results were ob- tained by patient questionnaires. Eight subjects were already taking a multivitamin that contained B12 and, in addition four of them were receiving B12 in another form, by intramuscular injection in three and in tablet form in one. On the face of it, the study might be considered to be unpublishable since the confounding factors are so obvious, but there are some re- deeming features that make it worth bringing to the attention of practicing physicians. This is strictly an "Outcomes" study, perhaps the methodology that is gradually going to replace the cumbersome and potentially fallacious double blind controlled study that has long been the "gold standard" of clinical research. Admittedly, no attempt was made to give the results statistical validity, but the small num- ber of subjects precludes that and rather it should

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Journal of Advancement in Medicine – Springer Journals

Published: Sep 30, 2004

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