Access the full text.
Sign up today, get DeepDyve free for 14 days.
Daleum Nam, Jee-Young Lee, Minhyung Lee, Janghwan Kim, W. Seol, I. Son, D. Ho (2020)
Detection and Assessment of α-Synuclein Oligomers in the Urine of Parkinson's Disease Patients.Journal of Parkinson's disease
A. Esteves, D. Arduíno, R. Swerdlow, C. Oliveira, S. Cardoso (2009)
Oxidative stress involvement in alpha-synuclein oligomerization in Parkinson's disease cybrids.Antioxidants & redox signaling, 11 3
Pedro Magalhães, H. Lashuel (2022)
Opportunities and challenges of alpha-synuclein as a potential biomarker for Parkinson’s disease and other synucleinopathiesNPJ Parkinson's Disease, 8
Juan Estaun-Panzano, M.-L. Arotçarena, Erwan Bezard (2023)
Monitoring α-synuclein aggregationNeurobiology of Disease, 176
Serene Chen, S. Drakulić, E. Deas, Myriam Ouberai, F. Aprile, R. Arranz, Samuel Ness, C. Roodveldt, Tim Guilliams, Erwin De-Genst, D. Klenerman, N. Wood, T. Knowles, C. Alfonso, G. Rivas, A. Abramov, J. Valpuesta, C. Dobson, N. Cremades (2015)
Structural characterization of toxic oligomers that are kinetically trapped during α-synuclein fibril formationProceedings of the National Academy of Sciences, 112
Hayate Javed, M. Meeran, S. Azimullah, A. Adem, B. Sadek, S. Ojha (2019)
Plant Extracts and Phytochemicals Targeting α-Synuclein Aggregation in Parkinson's Disease ModelsFrontiers in Pharmacology, 9
(2009)
Parkinson’s disease. Lancet 373:2055–2066
Giorgio Vivacqua, A. Latorre, A. Suppa, M. Nardi, S. Pietracupa, R. Mancinelli, G. Fabbrini, C. Colosimo, E. Gaudio, A. Berardelli (2016)
Abnormal Salivary Total and Oligomeric Alpha-Synuclein in Parkinson’s DiseasePLoS ONE, 11
M. Caruana, T. Högen, J. Levin, A. Hillmer, A. Giese, N. Vassallo (2011)
Inhibition and disaggregation of α‐synuclein oligomers by natural polyphenolic compoundsFEBS Letters, 585
B. Winner, R. Jappelli, S. Maji, Paula Desplats, Leah Boyer, S. Aigner, C. Hetzer, Thomas Loher, M. Vilar, S. Campioni, Christos Tzitzilonis, A. Soragni, S. Jessberger, H. Mira, A. Consiglio, E. Pham, E. Masliah, F. Gage, R. Riek (2011)
In vivo demonstration that α-synuclein oligomers are toxicProceedings of the National Academy of Sciences, 108
Sudhir Kumar, G. Stecher, Michael Li, Christina Knyaz, K. Tamura (2018)
MEGA X: Molecular Evolutionary Genetics Analysis across Computing Platforms.Molecular biology and evolution, 35 6
L. Bernal-Conde, Rodrigo Ramos-Acevedo, Mario Reyes-Hernández, Andrea Balbuena-Olvera, Ishbelt Morales-Moreno, R. Argüero-Sánchez, B. Schüle, M. Guerra-Crespo (2020)
Alpha-Synuclein Physiology and Pathology: A Perspective on Cellular Structures and OrganellesFrontiers in Neuroscience, 13
Y. Siddique, S. Mujtaba, Smita Jyoti, Falaq Naz (2013)
GC-MS analysis of Eucalyptus citriodora leaf extract and its role on the dietary supplementation in transgenic Drosophila model of Parkinson's disease.Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 55
(2012)
Fungal Barcoding Consortium (2012) Nuclear ribo
(2018)
The emerging evidence of the Parkinson ’ s disease pandemic
R. Takahashi, K. Ono, Y. Takamura, M. Mizuguchi, T. Ikeda, H. Nishijo, M. Yamada (2015)
Phenolic compounds prevent the oligomerization of α‐synuclein and reduce synaptic toxicityJournal of Neurochemistry, 134
A. Keston, R. Brandt (1965)
THE FLUOROMETRIC ANALYSIS OF ULTRAMICRO QUANTITIES OF HYDROGEN PEROXIDE.Analytical biochemistry, 11
P. Javvaji, A. Dhali, J. Francis, A. Kolte, A. Mech, S. Roy, A. Mishra, R. Bhatta (2020)
An Efficient Nitroblue Tetrazolium Staining and Bright-Field Microscopy Based Method for Detecting and Quantifying Intracellular Reactive Oxygen Species in Oocytes, Cumulus Cells and EmbryosFrontiers in Cell and Developmental Biology, 8
Carroll Fields, N. Bengoa-Vergniory, R. Wade-Martins (2019)
Targeting Alpha-Synuclein as a Therapy for Parkinson’s DiseaseFrontiers in Molecular Neuroscience, 12
MS Celej (2012)
719Biochem J, 443
K. Ono, Mayumi Tsuji, T. Yamasaki, G. Pasinetti (2020)
Anti-aggregation Effects of Phenolic Compounds on α-synucleinMolecules, 25
Conrad Schocha, Keith Seifertb, Sabine Huhndorfc, Vincent Robertd, John Spougea, C. Levesqueb, W. Chenb, Fungal Consortiuma (2012)
Nuclear ribosomal internal transcribed spacer (ITS) region as a universal DNA barcode marker for FungiProceedings of the National Academy of Sciences, 109
Hongshun Wang, J. Joseph (1999)
Quantifying cellular oxidative stress by dichlorofluorescein assay using microplate reader.Free radical biology & medicine, 27 5-6
Juan Zhao, Q. Liang, Qing Sun, Cong-heng Chen, Lihui Xu, Yu Ding, P. Zhou (2017)
(−)-Epigallocatechin-3-gallate (EGCG) inhibits fibrillation, disaggregates amyloid fibrils of α-synuclein, and protects PC12 cells against α-synuclein-induced toxicityRSC Advances, 7
M. Murer, R. Raisman‐Vozari, O. Gershanik (1999)
Levodopa in Parkinson’s DiseaseDrug Safety, 21
KK Griendling (2016)
e39Circ Res, 119
Hengtong Xie, Xiaoxiao Feng, Mengcen Wang, Yuefei Wang, Mukesh Awasthi, Ping Xu (2020)
Implications of endophytic microbiota in Camellia sinensis: a review on current understanding and future insightsBioengineered, 11
A. Fink (2006)
The aggregation and fibrillation of alpha-synuclein.Accounts of chemical research, 39 9
R. Berrocal, P. Vasudevaraju, S. Indi, K. Rao, K. Rao (2014)
In vitro evidence that an aqueous extract of Centella asiatica modulates α-synuclein aggregation dynamics.Journal of Alzheimer's disease : JAD, 39 2
T. White (1990)
Amplification and direct sequencing of fungal ribosomal RNA genes for phylogenetics, 18
Farida Gaamouch, Kalena Liu, Hsiao-Yun Lin, Clark Wu, Jun Wang (2021)
Development of grape polyphenols as multi-targeting strategies for Alzheimer's diseaseNeurochemistry International, 147
N. Kapoor, S. Saxena (2016)
Xanthine oxidase inhibitory and antioxidant potential of Indian Muscodor species3 Biotech, 6
A. Goswami, Priyanka Dikshit, A. Mishra, Shalaka Mulherkar, N. Nukina, N. Jana (2006)
Oxidative stress promotes mutant huntingtin aggregation and mutant huntingtin-dependent cell death by mimicking proteasomal malfunction.Biochemical and biophysical research communications, 342 1
Ditte Lundvig, E. Lindersson, P. Jensen (2005)
Pathogenic effects of α-synuclein aggregationMolecular Brain Research, 134
M. Bielecka, B. Pencakowski, R. Nicoletti (2022)
Using Next-Generation Sequencing Technology to Explore Genetic Pathways in Endophytic Fungi in the Syntheses of Plant Bioactive MetabolitesAgriculture
Xiaoqing Hu, Delu Dong, M. Xia, Yimeng Yang, Jiabin Wang, Jing Su, Liankun Sun, Huimei Yu (2020)
Oxidative stress and antioxidant capacity: development and prospectsNew Journal of Chemistry, 44
Natalia Mazo, V. Echeverria, R. Cabezas, Marco Avila-Rodriguez, V. Tarasov, N. Yarla, G. Aliev, G. Barreto (2017)
Medicinal Plants as Protective Strategies Against Parkinson's Disease.Current pharmaceutical design, 23 28
B. Schulz, C. Boyle (2005)
The endophytic continuum.Mycological research, 109 Pt 6
P. Jadiya, A. Khan, S. Sammi, Supinder Kaur, S. Mir, A. Nazir (2011)
Anti-Parkinsonian effects of Bacopa monnieri: insights from transgenic and pharmacological Caenorhabditis elegans models of Parkinson's disease.Biochemical and biophysical research communications, 413 4
E. Inoue, Y. Shimizu, R. Masui, Tomomi Hayakawa, Tomoe Tsubonoya, Satoko Hori, Keiichi Sudoh (2017)
Effects of saffron and its constituents, crocin-1, crocin-2, and crocetin on α-synuclein fibrilsJournal of Natural Medicines, 72
Ianara Costa, J. Cavalcanti, Dinalva Queiróz, Eduardo Azevedo, Amália Rêgo, Irami Filho, Paulo Parente, M. Botelho, F. Guzen (2017)
Supplementation with Herbal Extracts to Promote Behavioral and Neuroprotective Effects in Experimental Models of Parkinson's Disease: A Systematic ReviewPhytotherapy Research, 31
M. Kimura (1980)
A simple method for estimating evolutionary rates of base substitutions through comparative studies of nucleotide sequencesJournal of Molecular Evolution, 16
(2012)
Toxic prefibrillar alpha - synuclein amyloid oligomers adopt a distinctive antiparallel beta - sheet structure
L. Lassen, Emil Gregersen, Anne Isager, Cristine Betzer, R. Kofoed, P. Jensen (2018)
ELISA method to detect α-synuclein oligomers in cell and animal modelsPLoS ONE, 13
A. Najmi, S. Javed, M. Bratty, H. Alhazmi (2022)
Modern Approaches in the Discovery and Development of Plant-Based Natural Products and Their Analogues as Potential Therapeutic AgentsMolecules, 27
C. Henrich, J. Beutler (2013)
Matching the power of high throughput screening to the chemical diversity of natural products.Natural product reports, 30 10
R. Shaltiel-Karyo, D. Davidi, Moran Frenkel-Pinter, M. Ovadia, D. Segal, E. Gazit (2012)
Differential inhibition of α-synuclein oligomeric and fibrillar assembly in parkinson's disease model by cinnamon extract.Biochimica et biophysica acta, 1820 10
I. Visentin, G. Tamietti, D. Valentino, E. Portis, P. Karlovsky, A. Moretti, F. Cardinale (2009)
The ITS region as a taxonomic discriminator between Fusarium verticillioides and Fusarium proliferatum.Mycological research, 113 Pt 10
M. Goedert, Masami Masuda-Suzukake, B. Falcon (2017)
Like prions: the propagation of aggregated tau and &agr;-synuclein in neurodegenerationBrain, 140
A Venugopalan, S Srivastava (2015)
Endophytes as in vitro production platforms of high value plant secondary metabolitesBiotechnol Adv, 33
P. Brundin, K. Dave, J. Kordower (2017)
Therapeutic approaches to target alpha-synuclein pathologyExperimental Neurology, 298
Dennis Wilson (1995)
Endophyte: The Evolution of a Term, and Clarification of Its Use and DefinitionOikos, 73
J. Langston, B. Schüle, L. Rees, R Nichols, C. Barlow (2015)
Multisystem Lewy body disease and the other parkinsonian disordersNature Genetics, 47
M. Caruana, Johanna Neuner, T. Högen, F. Schmidt, F. Kamp, C. Scerri, A. Giese, N. Vassallo (2012)
Polyphenolic compounds are novel protective agents against lipid membrane damage by α-synuclein aggregates in vitro.Biochimica et biophysica acta, 1818 11
S. Witt, Todd Flower (2006)
α-Synuclein, oxidative stress and apoptosis from the perspective of a yeast model of Parkinson's diseaseFems Yeast Research, 6
Y. Lee, E. Burlet, Shaoxiao Wang, Baoshan Xu, Shile Huang, F. Galiano, S. Witt (2011)
Triclabendazole protects yeast and mammalian cells from oxidative stress: identification of a potential neuroprotective compound.Biochemical and biophysical research communications, 414 1
A. Fink (2006)
The Aggregation and Fibrillation of α-SynucleinAccounts of Chemical Research, 39
T. Rho, M. Choi, Mila Jung, H. Kil, Y. Hong, K. Yoon (2019)
Identification of fermented tea (Camellia sinensis) polyphenols and their inhibitory activities against amyloid-beta aggregation.Phytochemistry, 160
M. Caruana, N. Vassallo (2015)
Tea Polyphenols in Parkinson's Disease.Advances in experimental medicine and biology, 863
U. Kõljalg, K. Larsson, K. Abarenkov, R. Nilsson, I. Alexander, U. Eberhardt, S. Erland, K. Høiland, R. Kjøller, E. Larsson, T. Pennanen, R. Sen, Andy Taylor, L. Tedersoo, T. Vrålstad, B. Ursing (2005)
UNITE: a database providing web-based methods for the molecular identification of ectomycorrhizal fungi.The New phytologist, 166 3
Michael Wördehoff, W. Hoyer (2018)
α-Synuclein Aggregation Monitored by Thioflavin T Fluorescence Assay.Bio-protocol, 8 14
Ditte Lundvig, E. Lindersson, P. Jensen (2005)
Pathogenic effects of alpha-synuclein aggregation.Brain research. Molecular brain research, 134 1
G. Pezzoli, M. Zini (2010)
Levodopa in Parkinson's disease: from the past to the futureExpert Opinion on Pharmacotherapy, 11
D. Albani, L. Polito, Sara Batelli, Stefania Mauro, C. Fracasso, G. Martelli, L. Colombo, C. Manzoni, M. Salmona, S. Caccia, A. Negro, G. Forloni (2009)
The SIRT1 activator resveratrol protects SK‐N‐BE cells from oxidative stress and against toxicity caused by α‐synuclein or amyloid‐β (1‐42) peptideJournal of Neurochemistry, 110
P. Alam, Luc Bousset, R. Melki, D. Otzen (2019)
α‐synuclein oligomers and fibrils: a spectrum of species, a spectrum of toxicitiesJournal of Neurochemistry, 150
ER Dorsey (2018)
S3J Parkinsons Dis, 8
F. Pagán, M. Hebron, B. Wilmarth, Y. Torres-Yaghi, A. Lawler, E. Mundel, Nadia Yusuf, Nathan Starr, Joy Arellano, Helen Howard, Margo Peyton, S. Matar, Xiaoguang Liu, Alan Fowler, S. Schwartz, Jaeil Ahn, C. Moussa (2019)
Pharmacokinetics and pharmacodynamics of a single dose Nilotinib in individuals with Parkinson's diseasePharmacology Research & Perspectives, 7
Edward Chau, Hyunjoo Kim, J. Shin, Alberto Martinez, J. Kim (2021)
Inhibition of alpha-synuclein aggregation by AM17, a synthetic resveratrol derivative.Biochemical and biophysical research communications, 574
AJ Lees (2009)
2055Lancet, 373
S. Vats, Rajesh Kondabala, S. Saxena (2022)
Identification of alpha‐Synuclein Disaggregator from Camellia sp . Insight of Molecular Docking and Molecular Dynamics SimulationsChemistrySelect
(2016)
Measurement of reactive oxygen species , reactive nitrogen species , and redox - dependent signalling in the cardiovascular system
G. Strobel (2003)
Endophytes as sources of bioactive products.Microbes and infection, 5 6
Carissa Hansen, Douglas Miller, Stephanie Annarumma, C. Rusch, A. Ramirez-Zamora, H. Khoshbouei (2022)
Levodopa-induced dyskinesia: a historical review of Parkinson’s disease, dopamine, and modern advancements in research and treatmentJournal of Neurology, 269
(2016)
A (2016) Measurement of reactive
Sogra Musavi, R. Balakrishnan (2013)
Biodiversity, Antimicrobial Potential, and Phylogenetic Placement of an Endophytic Fusarium oxysporum NFX 06 Isolated from Nothapodytes foetida, 2013
A. Venugopalan, Smita Srivastava (2015)
Endophytes as in vitro production platforms of high value plant secondary metabolites.Biotechnology advances, 33 6 Pt 1
C. Lebel, H. Ischiropoulos, S. Bondy (1992)
Evaluation of the probe 2',7'-dichlorofluorescin as an indicator of reactive oxygen species formation and oxidative stress.Chemical research in toxicology, 5 2
N. Kapoor, S. Saxena (2014)
Potential Xanthine Oxidase Inhibitory Activity of Endophytic Lasiodiplodia pseudotheobromaeApplied Biochemistry and Biotechnology, 173
M. Caruana, Ruben Cauchi, N. Vassallo (2016)
Putative Role of Red Wine Polyphenols against Brain Pathology in Alzheimer’s and Parkinson’s DiseaseFrontiers in Nutrition, 3
Aggregation of α-synuclein into toxic oligomeric structures has been implicated in the pathogenesis of Parkinson’s disease via several key stages of fibrillation, oligomerization, and aggregation. Disaggregation or prevention of aggregation has garnered a lot of attention as a therapeutic strategy to prevent or delay the progression of Parkinson’s disease. It has been recently established that certain polyphenolic compounds and catechins present in plants and tea extracts exhibit the potential to inhibit the α-synuclein aggregation. However, their copious supply for therapeutic development is still unsolved. Herein, we report for the first time the disaggregation potential of α-synuclein by an endophytic fungus residing in tea leaves (Camellia sinensis). Briefly, a recombinant yeast expressing α-synuclein was used for pre-screening of 53 endophytic fungi isolated from tea using anti-oxidant activity as a marker for the disaggregation of the protein. One isolate #59CSLEAS exhibited 92.4% reduction in production of the superoxide ions, which were similar to the already established α-synuclein disaggregator, Piceatannol exhibiting 92.8% reduction. Thioflavin T assay further established that #59CSLEAS decreased the oligomerization of α-synuclein by 1.63-fold. Subsequently Dichloro-dihydro-fluorescein diacetate-based fluorescence assay exhibited a reduction in total oxidative stress in the recombinant yeast in the presence of fungal extract, thereby indicating the prevention of oligomerization. Oligomer disaggregation potential of the selected fungal extract was found to be 56.5% as assessed by sandwich ELISA assay. Using morphological as well as molecular methods, the endophytic isolate #59CSLEAS was identified as Fusarium sp. The sequence was submitted in the Genbank with accession number ON226971.1.
Archives of Microbiology – Springer Journals
Published: Jun 1, 2023
Keywords: Oxidative stress; Endophytic fungi; Camellia sinensis; Antioxidants; Parkinson’s disease
Read and print from thousands of top scholarly journals.
Already have an account? Log in
Bookmark this article. You can see your Bookmarks on your DeepDyve Library.
To save an article, log in first, or sign up for a DeepDyve account if you don’t already have one.
Copy and paste the desired citation format or use the link below to download a file formatted for EndNote
Access the full text.
Sign up today, get DeepDyve free for 14 days.
All DeepDyve websites use cookies to improve your online experience. They were placed on your computer when you launched this website. You can change your cookie settings through your browser.