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Fetal and infant origins of adult disease

Fetal and infant origins of adult disease Monatsschr Kinderheilkd Schw Schwangerschaf angerschaft t 2001 · [Suppl 1] 149:S 2–S 6 © Springer-Verlag 2001 D. J. P. Barker · MRC Environmental Epidemiology Unit, Southampton General Hospital, Southampton Fetal and infant origins of adult disease Abstract function – a phenomenon sometimes re- period when a system is plastic and sen- ferred to as programming. They allow the fe- sitive to the environment, followed by Background. Many human fetuses and in- tus to survive and continue to grow but at loss of plasticity and a fixed functional fants have to adapt to a limited supply of nu- the price of a shortened life. capacity. There are good reasons why it trients, and in doing so they permanently may be advantageous, in evolutionary change their physiology and metabolism. Keywords terms, for the body to remain plastic These programmed changes may be the ori- during development. Why this plasticity gins of a number of diseases in later life, in- Coronary heart disease · Fetal origins · is ultimately lost in most tissues and sys- cluding coronary heart disease, stroke, dia- Infant origins · Adaptations to undernutrition tems is a question to which we have on- betes and hypertension. ly speculative answers. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Monatsschrift Kinderheilkunde Springer Journals

Fetal and infant origins of adult disease

Monatsschrift Kinderheilkunde , Volume 149 (1) – Jun 1, 2001

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References (41)

Publisher
Springer Journals
Copyright
Copyright © 2001 by Springer-Verlag Berlin Heidelberg
Subject
Medicine & Public Health; Pediatrics; General Practice / Family Medicine
ISSN
0026-9298
DOI
10.1007/s001120170002
Publisher site
See Article on Publisher Site

Abstract

Monatsschr Kinderheilkd Schw Schwangerschaf angerschaft t 2001 · [Suppl 1] 149:S 2–S 6 © Springer-Verlag 2001 D. J. P. Barker · MRC Environmental Epidemiology Unit, Southampton General Hospital, Southampton Fetal and infant origins of adult disease Abstract function – a phenomenon sometimes re- period when a system is plastic and sen- ferred to as programming. They allow the fe- sitive to the environment, followed by Background. Many human fetuses and in- tus to survive and continue to grow but at loss of plasticity and a fixed functional fants have to adapt to a limited supply of nu- the price of a shortened life. capacity. There are good reasons why it trients, and in doing so they permanently may be advantageous, in evolutionary change their physiology and metabolism. Keywords terms, for the body to remain plastic These programmed changes may be the ori- during development. Why this plasticity gins of a number of diseases in later life, in- Coronary heart disease · Fetal origins · is ultimately lost in most tissues and sys- cluding coronary heart disease, stroke, dia- Infant origins · Adaptations to undernutrition tems is a question to which we have on- betes and hypertension. ly speculative answers.

Journal

Monatsschrift KinderheilkundeSpringer Journals

Published: Jun 1, 2001

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