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Health and Cognition in Old AgeHow the Aging Process Affects Our Immune System: Mechanisms, Consequences, and Perspectives for Intervention

Health and Cognition in Old Age: How the Aging Process Affects Our Immune System: Mechanisms,... [The aging of the immune system involves a complex set of changes that is collectively referred to as immune senescence. Clinically, immune senescence has been associated with decreased protection following vaccinations, increased morbidity and mortality from infectious diseases, increased risk of cancer, and increased incidence of autoimmune and inflammatory diseases. Although our understanding of the mechanisms that drive immune senescence has improved during the past decades, we are still far away from therapies that would be able to delay or even prevent the development of immune senescence in humans. This book chapter will illustrate our current knowledge of how the aging process affects our immune system, which key factors are responsible for the aging of immune cells, how environmental factors such as certain life-long viral infections may affect immunological aging, and what challenges the scientific community has to overcome to successfully implement strategies that delay or prevent immunosenescence and thereby increase the human health span.] http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png

Health and Cognition in Old AgeHow the Aging Process Affects Our Immune System: Mechanisms, Consequences, and Perspectives for Intervention

Part of the International Perspectives on Aging Book Series (volume 10)
Editors: Leist, Anja K.; Kulmala, Jenni; Nyqvist, Fredrica
Herndler-Brandstetter, Dietmar
Health and Cognition in Old Age — Jun 10, 2014
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References (142)

Publisher
Springer International Publishing
Copyright
© Springer International Publishing Switzerland 2014
ISBN
978-3-319-06649-3
Pages
55 –69
DOI
10.1007/978-3-319-06650-9_5
Publisher site
See Chapter on Publisher Site

Abstract

[The aging of the immune system involves a complex set of changes that is collectively referred to as immune senescence. Clinically, immune senescence has been associated with decreased protection following vaccinations, increased morbidity and mortality from infectious diseases, increased risk of cancer, and increased incidence of autoimmune and inflammatory diseases. Although our understanding of the mechanisms that drive immune senescence has improved during the past decades, we are still far away from therapies that would be able to delay or even prevent the development of immune senescence in humans. This book chapter will illustrate our current knowledge of how the aging process affects our immune system, which key factors are responsible for the aging of immune cells, how environmental factors such as certain life-long viral infections may affect immunological aging, and what challenges the scientific community has to overcome to successfully implement strategies that delay or prevent immunosenescence and thereby increase the human health span.]

Published: Jun 10, 2014

Keywords: Infective Endocarditis; Herpes Zoster; Varicella Zoster Virus; Influenza Vaccination; Somatic Stem Cell

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