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Identification of Free Radicals Formed in Gamma-Irradiated Acetazolamide Using Electron Paramagnetic Resonance Spectroscopy

Identification of Free Radicals Formed in Gamma-Irradiated Acetazolamide Using Electron... In this study, spectroscopic, dosimetric and stability characteristics of free radicals formed in acetazolamide (ACE) sample as a result of gamma irradiation in the range of 0–15 kGy were determined using electron paramagnetic resonance (EPR) spectroscopy. For this purpose, by interpreting the spectra of the sample in the 0–100 mW microwave power region, it was determined that two different radicals were formed in the sample. The structures formed after irradiation were attributed to CH3OṄ-(radical I) and -OSOṄH (radical II) radicals. The g-values, hyperfine coupling constants and spectrum contribution ratios of these radicals contributing to the experimental spectrum were also calculated. It has been determined that radical II is quite stable both at high temperature and after a long storage period. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Applied Magnetic Resonance Springer Journals

Identification of Free Radicals Formed in Gamma-Irradiated Acetazolamide Using Electron Paramagnetic Resonance Spectroscopy

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References (33)

Publisher
Springer Journals
Copyright
Copyright © The Author(s), under exclusive licence to Springer-Verlag GmbH Austria, part of Springer Nature 2023. Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.
ISSN
0937-9347
eISSN
1613-7507
DOI
10.1007/s00723-023-01551-w
Publisher site
See Article on Publisher Site

Abstract

In this study, spectroscopic, dosimetric and stability characteristics of free radicals formed in acetazolamide (ACE) sample as a result of gamma irradiation in the range of 0–15 kGy were determined using electron paramagnetic resonance (EPR) spectroscopy. For this purpose, by interpreting the spectra of the sample in the 0–100 mW microwave power region, it was determined that two different radicals were formed in the sample. The structures formed after irradiation were attributed to CH3OṄ-(radical I) and -OSOṄH (radical II) radicals. The g-values, hyperfine coupling constants and spectrum contribution ratios of these radicals contributing to the experimental spectrum were also calculated. It has been determined that radical II is quite stable both at high temperature and after a long storage period.

Journal

Applied Magnetic ResonanceSpringer Journals

Published: Aug 1, 2023

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