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Microchip-Based Assay SystemsLectin Microarrays for Glycoprotein Analysis

Microchip-Based Assay Systems: Lectin Microarrays for Glycoprotein Analysis [Glycosylation is one of the most common posttranslational modifications, with more than half of all known proteins thought to be glycoproteins. Alterations in glycosylation play a role in a diverse set of biological phenomena including tumor cell metastasis, intracellular communication, and inflammation. The complexity of glycosylation at the molecular level and the lack of rapid analytical tools complicate the study of glycan function. We have recently developed a lectin microarray for the high-throughput analysis of glycosylation. Lectins are carbohydrate-binding proteins that have been used for decades as a detection method for glycans. By placing the lectins in a microarray format and using standard microarray printing and scanning technology, we have created a simple yet powerful technique for glycan profiling.] http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png

Microchip-Based Assay SystemsLectin Microarrays for Glycoprotein Analysis

Part of the Methods in Molecular Biology™ Book Series (volume 385)
Editors: Floriano, Pierre N.

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References (11)

Publisher
Humana Press
Copyright
© Humana Press 2007
ISBN
978-1-58829-588-0
Pages
193 –203
DOI
10.1007/978-1-59745-426-1_14
Publisher site
See Chapter on Publisher Site

Abstract

[Glycosylation is one of the most common posttranslational modifications, with more than half of all known proteins thought to be glycoproteins. Alterations in glycosylation play a role in a diverse set of biological phenomena including tumor cell metastasis, intracellular communication, and inflammation. The complexity of glycosylation at the molecular level and the lack of rapid analytical tools complicate the study of glycan function. We have recently developed a lectin microarray for the high-throughput analysis of glycosylation. Lectins are carbohydrate-binding proteins that have been used for decades as a detection method for glycans. By placing the lectins in a microarray format and using standard microarray printing and scanning technology, we have created a simple yet powerful technique for glycan profiling.]

Published: Jan 1, 2007

Keywords: Lectin microarray; glycomics; carbohydrate analysis; glycan profiling; array

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