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- Publisher
- Springer International Publishing
- Copyright
- © Springer International Publishing Switzerland 2014
- ISBN
- 978-3-319-08161-8
- Pages
- 65 –75
- DOI
- 10.1007/978-3-319-08162-5_6
- Publisher site
- See Chapter on Publisher Site
Abstract
[Metastatic breast cancers are difficult to manage, and brain metastatic breast cancers are particularly lethal with poor overall survival and outcomes. Our understanding of factors that facilitate brain metastasis of breast cancers is very poor. However, a number of studies in the last few years have focused on brain metastatic breast cancers; a number of therapeutic targets have been tested, and few therapeutic regimes have also been evaluated in phase I/II settings. We discuss here some of the most recent developments in the field. We will limit our discussion to the reports from past one year only to make this article most up-to-date with no repetition of information that has already been reviewed in the available literature.]
Published: Sep 6, 2014
Keywords: Breast cancer; Brain metastasis; Blood–brain barrier; Estrogen receptor-negative breast cancer; HER2-positive breast cancer