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Poly(para toluene sulphonic acid) and gold nanoparticles modified glassy carbon electrode for simultaneous voltammetric sensing of xanthine and hypoxanthine

Poly(para toluene sulphonic acid) and gold nanoparticles modified glassy carbon electrode for... A voltammetric sensor has been developed for the individual as well as simultaneous determination of xanthine (XA) and hypoxanthine (HX) based on an electroactive-polymerised layer of para toluene sulphonic acid and gold nanoparticles composite modified glassy carbon electrode ([p(PTSA)]/AuNPs/GCE)]. Under optimized conditions, an enhancement in the oxidation currents with well-separated and well-resolved peak position and a lower shift in the peak potentials were observed. By square wave voltammetry, the simultaneous determinations of XA and HX were achieved in the linear ranges 6.00 × 10–4 M to 3.00 × 10–6 M and 5.00 × 10–4 M to 1.00 × 10–5 M with detection limits of 4.09 × 10–7 M and 4.10 × 10–7 M, respectively. The mechanistic aspects were unveiled from linear sweep voltammetric studies and found that the electrode processes were diffusion-controlled. Finally, the sensor was successfully employed for the simultaneous determination of spiked amount of XA and HX in synthetic urine and serum samples.Graphical abstract[graphic not available: see fulltext] http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Analytical Sciences Springer Journals

Poly(para toluene sulphonic acid) and gold nanoparticles modified glassy carbon electrode for simultaneous voltammetric sensing of xanthine and hypoxanthine

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References (38)

Publisher
Springer Journals
Copyright
Copyright © The Author(s), under exclusive licence to The Japan Society for Analytical Chemistry 2023. Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.
ISSN
0910-6340
eISSN
1348-2246
DOI
10.1007/s44211-023-00379-5
Publisher site
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Abstract

A voltammetric sensor has been developed for the individual as well as simultaneous determination of xanthine (XA) and hypoxanthine (HX) based on an electroactive-polymerised layer of para toluene sulphonic acid and gold nanoparticles composite modified glassy carbon electrode ([p(PTSA)]/AuNPs/GCE)]. Under optimized conditions, an enhancement in the oxidation currents with well-separated and well-resolved peak position and a lower shift in the peak potentials were observed. By square wave voltammetry, the simultaneous determinations of XA and HX were achieved in the linear ranges 6.00 × 10–4 M to 3.00 × 10–6 M and 5.00 × 10–4 M to 1.00 × 10–5 M with detection limits of 4.09 × 10–7 M and 4.10 × 10–7 M, respectively. The mechanistic aspects were unveiled from linear sweep voltammetric studies and found that the electrode processes were diffusion-controlled. Finally, the sensor was successfully employed for the simultaneous determination of spiked amount of XA and HX in synthetic urine and serum samples.Graphical abstract[graphic not available: see fulltext]

Journal

Analytical Sciences – Springer Journals

Published: Oct 1, 2023

Keywords: Poly(para toluene sulphonic acid); Gold nanoparticles; Xanthine; Hypoxanthine; Voltammetry; Electro-oxidation

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