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Stark Effect Modeling in Raman Spectra Analysis of Histological Preparations of Colorectal Adenocarcinomas

Stark Effect Modeling in Raman Spectra Analysis of Histological Preparations of Colorectal... A complex analysis was made of histological preparations of the large intestine without pathology, chronic colitis, and surgical material of primary colorectal adenocarcinoma with due allowance for recovery of the patients after standard treatment by confocal Raman spectroscopy with spatial resolution. It was shown that the main difference in the spectra of the normal and pathologically changed tissues are the positions and relative intensities of the vibrational bands at frequencies of 1248, 1537, 1587, and 1620 cm–1. The spectral changes were analyzed in terms of the Stark approach on the assumption of change of the local electric field in the epithelial cells during oncogenesis. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Journal of Applied Spectroscopy Springer Journals

Stark Effect Modeling in Raman Spectra Analysis of Histological Preparations of Colorectal Adenocarcinomas

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References (10)

Publisher
Springer Journals
Copyright
Copyright © Springer Science+Business Media, LLC, part of Springer Nature 2023. Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.
ISSN
0021-9037
eISSN
1573-8647
DOI
10.1007/s10812-023-01534-6
Publisher site
See Article on Publisher Site

Abstract

A complex analysis was made of histological preparations of the large intestine without pathology, chronic colitis, and surgical material of primary colorectal adenocarcinoma with due allowance for recovery of the patients after standard treatment by confocal Raman spectroscopy with spatial resolution. It was shown that the main difference in the spectra of the normal and pathologically changed tissues are the positions and relative intensities of the vibrational bands at frequencies of 1248, 1537, 1587, and 1620 cm–1. The spectral changes were analyzed in terms of the Stark approach on the assumption of change of the local electric field in the epithelial cells during oncogenesis.

Journal

Journal of Applied SpectroscopySpringer Journals

Published: May 1, 2023

Keywords: Stark effect; Raman microspectroscopy; colorectal adenocarcinoma

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