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Molecular Systems Biology 3; Article number 82; doi:10.1038/msb4100125 Citation: Molecular Systems Biology 3:82
- Publisher
- Springer Netherlands
- Copyright
- © The Author(s) 2012
- ISBN
- 978-94-007-2848-6
- Pages
- 87 –102
- DOI
- 10.1007/978-94-007-2849-3_8
- Publisher site
- See Chapter on Publisher Site
Abstract
[In order to cover bottom-up and top-down phenomena multiscale SB simulation tools should include organ-level considerations, and should be used in conjunction with multiscale modeling tools which have the ability to handle many orders of magnitude in both length and timescale. Several new R&D paradigms, based on CSB, are proposed, while some are already in the research stage. This effort will lead to virtual organ/disease models, emerging as important tools. Identifying and targeting a system’s emergent properties is a major goal for coming years. This will cause a paradigm shift in R&D activity in Pharma yielding a move from population models to models of individualized medicine. The importance of multiscale CSB is underlined here as a great attention is given here in this section.]
Published: Jan 4, 2012
Keywords: Cellular Automaton; Parkinson Disease; Emergent Property; Multiscale Model; Correlation Network