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- Publisher
- Springer Netherlands
- Copyright
- © The Author(s) 2012
- ISBN
- 978-94-007-2848-6
- Pages
- 11 –23
- DOI
- 10.1007/978-94-007-2849-3_2
- Publisher site
- See Chapter on Publisher Site
Abstract
[In our introduction, we emphasized that a combination of reductionist (mechanism-based) and holistic (hypothesis-based) tools in the drug screening process may increase the efficiency of overall Drug Discovery. Among notable holistic tools are screens that target discovery and characterization of molecular probes (compounds) that will enable the investigation of fundamental biological function at molecular, cellular and whole organism levels. Such screening usually occurs at the earlier stages of drug discovery.]
Published: Jan 4, 2012
Keywords: Virtual Screening; QSAR Model; Combinatorial Chemistry; Lead Discovery; HQSAR Model