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- Publisher
- Springer Netherlands
- Copyright
- © The Author(s) 2012
- ISBN
- 978-94-007-2848-6
- Pages
- 25 –38
- DOI
- 10.1007/978-94-007-2849-3_3
- Publisher site
- See Chapter on Publisher Site
Abstract
[This chapter represents a mix of reductionist and holistic tools. Molecular screens and Biomimetics represent advanced reductionist approaches—the former are well established in the industry, although still developing. Similarly, the collateral efficacy/permissive antagonism concept may add to this effort, possibly generating new targets. Solving different co-drugging modalities represents a typical SB approach. Likewise, text mining does add to the holistic (global) effort. Tools to analyze biochemical networks and the phenomenon of emergence may lead to the establishment of ‘new biology’ or computational systems biology (CSB). Reactome analysis and bioinformatics tools only reinforce this effort. The level of development of the above quantitative tools is not uniform: some are advanced and mature (e.g., molecular screens), some require more inputs and are undergoing rapid evolution.]
Published: Jan 4, 2012
Keywords: Biochemical Network; Computational System Biology; Detailed Kinetic Model; Multistage Target; Unstructured Textual Data