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Y. Wang, Zhixiang Ma, Douglas Quinn, E. Fu (2001)
Inverse 18O labeling mass spectrometry for the rapid identification of marker/target proteins.Analytical chemistry, 73 15
A. Deora, K. Luettich, C. Schmidt, G. Sclabas (2003)
First anniversary of Molecular Cancer: achievements and future goalsMolecular Cancer, 2
Y. Kaznessis (2007)
Models for synthetic biologyBMC Systems Biology, 1
E. Werner (2003)
In silico multicellular systems biology and minimal genomes.Drug discovery today, 8 24
P. Hu, Gary Bader, D. Wigle, A. Emili (2007)
Computational prediction of cancer-gene functionNature Reviews Cancer, 7
Minal Vaish (2007)
Mismatch repair deficiencies transforming stem cells into cancer stem cells and therapeutic implicationsMolecular Cancer, 6
B. Metaferia, Lin Chen, Heather Baker, Xin-Yun Huang, C. Bewley (2007)
Synthetic macrolides that inhibit breast cancer cell migration in vitro.Journal of the American Chemical Society, 129 9
S. Zotchev, A. Stepanchikova, A. Sergeyko, B. Sobolev, D. Filimonov, V. Poroikov (2006)
Rational design of macrolides by virtual screening of combinatorial libraries generated through in silico manipulation of polyketide synthases.Journal of medicinal chemistry, 49 6
Xin Chen, E. Jorgenson, S. Cheung (2009)
New tools for functional genomic analysis.Drug discovery today, 14 15-16
V. Kumar, Madhukar Dasika, C. Maranas (2007)
Optimization based automated curation of metabolic reconstructionsBMC Bioinformatics, 8
X. Zheng, T. Chan (2002)
Chemical genomics: a systematic approach in biological research and drug discovery.Current issues in molecular biology, 4 2
M. Marchisio, J. Stelling (2009)
Computational design tools for synthetic biology.Current opinion in biotechnology, 20 4
Jong Lee, Erwin Gianchandani, James Eddy, J. Papin (2008)
Dynamic Analysis of Integrated Signaling, Metabolic, and Regulatory NetworksPLoS Computational Biology, 4
E. Petricoin, C. Belluco, R. Araujo, L. Liotta (2006)
The blood peptidome: a higher dimension of information content for cancer biomarker discoveryNature Reviews Cancer, 6
E. Maréchal (2008)
Chemogenomics: a discipline at the crossroad of high throughput technologies, biomarker research, combinatorial chemistry, genomics, cheminformatics, bioinformatics and artificial intelligence.Combinatorial chemistry & high throughput screening, 11 8
N. Alon, Phuong Dao, I. Hajirasouliha, F. Hormozdiari, S. Sahinalp (2008)
Biomolecular network motif counting and discovery by color codingBioinformatics, 24
Sarah Larson, L. Godley (2010)
Getting to the root of the stem cell in mutated chronic myeloid leukemiaLeukemia & Lymphoma, 51
A. Sackmann, M. Heiner, I. Koch (2006)
Application of Petri net based analysis techniques to signal transduction pathwaysBMC Bioinformatics, 7
X. Ling (2008)
High throughput screening informatics.Combinatorial chemistry & high throughput screening, 11 3
Anthony Forster, G. Church (2006)
Towards synthesis of a minimal cellMolecular Systems Biology, 2
Claire Christensen, J. Thakar, R. Albert (2007)
Systems-level insights into cellular regulation: inferring, analysing, and modelling intracellular networks.IET systems biology, 1 2
J. Papin, B. Palsson (2004)
Topological analysis of mass-balanced signaling networks: a framework to obtain network properties including crosstalk.Journal of theoretical biology, 227 2
Shihua Zhang, G. Jin, Xiang-Sun Zhang, Luonan Chen (2007)
Discovering functions and revealing mechanisms at molecular level from biological networksPROTEOMICS, 7
K. Hollywood, D. Brison, R. Goodacre (2006)
Metabolomics: Current technologies and future trendsPROTEOMICS, 6
V. Birault, C. Harris, Joelle Le, M. Lipkin, Ravi Nerella, A. Stevens (2006)
Bringing kinases into focus: efficient drug design through the use of chemogenomic toolkits.Current medicinal chemistry, 13 15
C. Francke, R. Siezen, B. Teusink (2005)
Reconstructing the metabolic network of a bacterium from its genome.Trends in microbiology, 13 11
N. Nicolaides, W. Ebel, Brad Kline, Qimin Chao, E. Routhier, P. Sass, L. Grasso (2005)
Morphogenics as a Tool for Target Discovery and Drug DevelopmentAnnals of the New York Academy of Sciences, 1059
J. Papin, T. Hunter, B. Palsson, S. Subramaniam (2005)
Reconstruction of cellular signalling networks and analysis of their propertiesNature Reviews Molecular Cell Biology, 6
Longshan Li, J. Morales, A. Hwang, M. Wagner, D. Boothman (2008)
DNA Mismatch Repair-dependent Activation of c-Abl/p73α/GADD45α-mediated Apoptosis*Journal of Biological Chemistry, 283
Hugo Menzella, Sarah Reisinger, M. Welch, J. Kealey, J. Kennedy, Ralph Reid, Chau Tran, D. Santi (2005)
Redesign, synthesis and functional expression of the 6-deoxyerythronolide B polyketide synthase gene clusterJournal of Industrial Microbiology and Biotechnology, 33
P. Goss, J. Peccoud (1998)
Quantitative modeling of stochastic systems in molecular biology by using stochastic Petri nets.Proceedings of the National Academy of Sciences of the United States of America, 95 12
V. Nikiforova, L. Willmitzer (2007)
Network visualization and network analysis.EXS, 97
J. Rice, Y. Tu, G. Stolovitzky (2005)
Reconstructing biological networks using conditional correlation analysisBioinformatics, 21 6
S. Jun, Tae Kim, C. Ban (2006)
DNA mismatch repair systemThe FEBS Journal, 273
Adam Feist, Markus Herrgård, I. Thiele, Jennie Reed, B. Palsson (2009)
Reconstruction of biochemical networks in microorganismsNature Reviews Microbiology, 7
[Many different OMICs/HTS techniques now allow huge amounts of molecular signatures to be collected and then analysed further by system tools. Among them, ChIP-on-chip is used to investigate interactions between proteins and DNA in vivo. Chemogenomics, morphogenics and synthetic biology are only in the early stages of development, but may contribute to target identification. A key SB tool, the reconstruction of biological networks, represents an emerging field, undergoing explosive expansion, and will likely enable efficient mapping of gene onto function.]
Published: Jan 4, 2012
Keywords: Synthetic Biology; High Throughput Screening; Flux Balance Analysis; Network Reconstruction; Ontology Building
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