Access the full text.
Sign up today, get DeepDyve free for 14 days.
Loading next page...
/lp/springer-journals/the-abcs-of-gene-cloning-finding-disease-causing-genes-pZwcUUEF7T
References (8)
-
L. HalaasJeffrey, Gajiwala Ketan, M. Maffei, Steven Cohen, B. Chait, Daniel Rabinowitz, R. Lallone, S. Burley, J. Friedman (1995)
Weight-reducing effects of the plasma protein encoded by the obese gene.Science, 269 5223
-
A. Buckler, D. Chang, S. Graw, J. Brook, D. Haber, P. Sharp, D. Housman (1991)
Exon amplification: a strategy to isolate mammalian genes based on RNA splicing.Proceedings of the National Academy of Sciences of the United States of America, 88
-
A. Poustka, T. Pohl, D. Barlow, A. Frischauf, H. Lehrach (1987)
Construction and use of human chromosome jumping libraries from NotI-digested DNANature, 325
-
Collins Fs (1991)
Of needles and haystacks: finding human disease genes by positional cloning.Clinical research, 39
-
M. Pelleymounter, M. Cullen, M. Baker, R. Hecht, D. Winters, Thomas Boone, F. Collins (1995)
Effects of the obese gene product on body weight regulation in ob/ob mice.Science, 269 5223
-
R. White, J. Lalouel (1988)
Chromosome mapping with DNA markers.Scientific American, 258 2
-
Yiying Zhang, R. Proenca, M. Maffei, M. Barone, L. Leopold, J. Friedman (1994)
Positional cloning of the mouse obese gene and its human homologueNature, 372
-
R. Anand (1992)
Yeast artificial chromosomes (YACs) and the analysis of complex genomes.Trends in biotechnology, 10 1-2
- Publisher
- Springer International Publishing
- Copyright
- © Springer International Publishing AG, part of Springer Nature 2018
- ISBN
- 978-3-319-77762-7
- Pages
- 167 –176
- DOI
- 10.1007/978-3-319-77982-9_18
- Publisher site
- See Chapter on Publisher Site
Abstract
[Among some 4000 known human genetic disorders, only a handful of disease-causing genes have been mapped. To locate a gene (say an average of 10,000 bp length) in the midst of a 3.2 billion bp genome is hardly a simple task.]
Published: May 27, 2018
Keywords: Disease-causing Genes; Yeast Artificial Chromosome (YAC); Yeast Artificial Chromosome Cloning Vectors; Autonomously Replicating Sequence (ARS); Short Tandem Repeat (STR)